File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Electroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammation

TitleElectroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammation
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh
Citation
Pharmacology Biochemistry And Behavior, 2005, v. 81 n. 1, p. 146-151 How to Cite?
AbstractOur previous study showed that electroacupuncture (EA), an adjuvant to conventional medicine, significantly attenuated hyperalgesia in a rat model of inflammatory pain. In the present study, we evaluated the potential additive and/or synergism of EA and a sub-effective dose of dizocilpine maleate (MK-801), a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, on hyperalgesia in the same rat model of inflammatory pain. Hyperalgesia, manifesting as decreased paw withdrawal latency (PWL) to a noxious stimulus, was induced by injecting complete Freund's adjuvant (CFA) into the plantar surface of one hind paw of each rat. EA treatments were given at acupoint GB30 immediately after and 2 h after CFA. MK-801 at 0.001 mg/rat was given (i.t.) 10 min before each of the two EA treatments. PWL was measured prior to and 2.5 and 5 h post-CFA. Ten and 100 Hz EA significantly inhibited CFA-induced hind paw hyperalgesia. Both 10 and 100 Hz EA combined with the sub-effective dose of 0.001 mg/rat MK-801 showed prolonged anti-hyperalgesia with no side effects. These results demonstrate that EA combined with a sub-effective dose of this NMDA receptor antagonist enhances anti-hyperalgesia, and this combination may provide an effective strategy for pain management. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188569
ISSN
2015 Impact Factor: 2.537
2015 SCImago Journal Rankings: 1.121
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, RXen_US
dc.contributor.authorWang, Len_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorRen, Ken_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorLao, Len_US
dc.date.accessioned2013-09-03T04:10:20Z-
dc.date.available2013-09-03T04:10:20Z-
dc.date.issued2005en_US
dc.identifier.citationPharmacology Biochemistry And Behavior, 2005, v. 81 n. 1, p. 146-151en_US
dc.identifier.issn0091-3057en_US
dc.identifier.urihttp://hdl.handle.net/10722/188569-
dc.description.abstractOur previous study showed that electroacupuncture (EA), an adjuvant to conventional medicine, significantly attenuated hyperalgesia in a rat model of inflammatory pain. In the present study, we evaluated the potential additive and/or synergism of EA and a sub-effective dose of dizocilpine maleate (MK-801), a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, on hyperalgesia in the same rat model of inflammatory pain. Hyperalgesia, manifesting as decreased paw withdrawal latency (PWL) to a noxious stimulus, was induced by injecting complete Freund's adjuvant (CFA) into the plantar surface of one hind paw of each rat. EA treatments were given at acupoint GB30 immediately after and 2 h after CFA. MK-801 at 0.001 mg/rat was given (i.t.) 10 min before each of the two EA treatments. PWL was measured prior to and 2.5 and 5 h post-CFA. Ten and 100 Hz EA significantly inhibited CFA-induced hind paw hyperalgesia. Both 10 and 100 Hz EA combined with the sub-effective dose of 0.001 mg/rat MK-801 showed prolonged anti-hyperalgesia with no side effects. These results demonstrate that EA combined with a sub-effective dose of this NMDA receptor antagonist enhances anti-hyperalgesia, and this combination may provide an effective strategy for pain management. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembehen_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.subject.meshAnalgesia - Methodsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDizocilpine Maleate - Therapeutic Useen_US
dc.subject.meshElectroacupuncture - Methodsen_US
dc.subject.meshHyperalgesia - Drug Therapy - Therapyen_US
dc.subject.meshInflammation - Drug Therapy - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshPain Measurement - Drug Effects - Methodsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleElectroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.pbb.2005.03.002en_US
dc.identifier.pmid15894072-
dc.identifier.scopuseid_2-s2.0-19344373492en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-19344373492&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume81en_US
dc.identifier.issue1en_US
dc.identifier.spage146en_US
dc.identifier.epage151en_US
dc.identifier.isiWOS:000229530000018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridWang, L=9036448600en_US
dc.identifier.scopusauthoridWang, X=7501857339en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats