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Article: Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation

TitleEffects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation
Authors
Issue Date2005
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/acm
Citation
Journal Of Alternative And Complementary Medicine, 2005, v. 11 n. 2, p. 323-331 How to Cite?
AbstractObjective: Ruxiang, or Gummi olibanum, an herbal medicine derived from the gum resin of Boswellia carterii Birdw. (BC) of the family Burseraceae, has been used traditionally in China to alleviate pain and reduce inflammation. The present study is an investigation of the effects of a BC extract on persistent hyperalgesia and edema in rats with peripheral inflammation. Design: In this randomized, blinded study, the antihyperalgesic and antiedema effects of 3 dosages of BC were compared to a vehicle control. Inflammation was induced in rats by injecting complete Freund's adjuvant (CFA) into one hind paw. A single oral dose of the BC extract was administered daily for 7 days, beginning one day before CFA. Hyperalgesia was assessed using a paw withdrawal latency (PWL) test pre-CFA and 2 hours, 5 hours, 1 day, and 5 days post-CFA. Edema was determined by measuring paw thickness at the same time points. Spinal Fos protein expression was analyzed 2 hours post-CFA. Adverse effects of the extract were monitored by observing the animals closely for unusual behavioral changes. Results: Compared to control, a dosage of 0.45 g/kg BC significantly lengthened PWL and reduced paw edema on day 5 post-CFA. At 0.90 g/kg, BC significantly lengthened PWL at 5 hours, 1 day, and 5 days, and reduced paw edema at 2 hours, 5 hours, 1 day, and 5 days. This dosage also significantly suppressed spinal Fos expression in the medial half of laminae I-II. At 1.80 g/kg, BC significantly lengthened PWL and reduced paw edema at all time points. No noticeable adverse effects were observed in animals given the lower dosages of BC, but adverse effects in some animals were observed at 1.80 g/kg per day. In the acute toxicity study, the maximal single dose of 2.50 g/kg produced no adverse effects in the treated rats during the 14 days of observation. Conclusions: The data suggest that BC produces significant antihyperalgesia and anti-inflammation effects and that the antihyperalgesia may be mediated by suppressed inflammation-induced Fos expression in the spinal dorsal horn neurons. © Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/188567
ISSN
2015 Impact Factor: 1.395
2015 SCImago Journal Rankings: 0.475
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFan, AYen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorZhang, RXen_US
dc.contributor.authorWang, LBen_US
dc.contributor.authorLee, DYWen_US
dc.contributor.authorMa, ZZen_US
dc.contributor.authorZhang, WYen_US
dc.contributor.authorBerman, Ben_US
dc.date.accessioned2013-09-03T04:10:19Z-
dc.date.available2013-09-03T04:10:19Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Alternative And Complementary Medicine, 2005, v. 11 n. 2, p. 323-331en_US
dc.identifier.issn1075-5535en_US
dc.identifier.urihttp://hdl.handle.net/10722/188567-
dc.description.abstractObjective: Ruxiang, or Gummi olibanum, an herbal medicine derived from the gum resin of Boswellia carterii Birdw. (BC) of the family Burseraceae, has been used traditionally in China to alleviate pain and reduce inflammation. The present study is an investigation of the effects of a BC extract on persistent hyperalgesia and edema in rats with peripheral inflammation. Design: In this randomized, blinded study, the antihyperalgesic and antiedema effects of 3 dosages of BC were compared to a vehicle control. Inflammation was induced in rats by injecting complete Freund's adjuvant (CFA) into one hind paw. A single oral dose of the BC extract was administered daily for 7 days, beginning one day before CFA. Hyperalgesia was assessed using a paw withdrawal latency (PWL) test pre-CFA and 2 hours, 5 hours, 1 day, and 5 days post-CFA. Edema was determined by measuring paw thickness at the same time points. Spinal Fos protein expression was analyzed 2 hours post-CFA. Adverse effects of the extract were monitored by observing the animals closely for unusual behavioral changes. Results: Compared to control, a dosage of 0.45 g/kg BC significantly lengthened PWL and reduced paw edema on day 5 post-CFA. At 0.90 g/kg, BC significantly lengthened PWL at 5 hours, 1 day, and 5 days, and reduced paw edema at 2 hours, 5 hours, 1 day, and 5 days. This dosage also significantly suppressed spinal Fos expression in the medial half of laminae I-II. At 1.80 g/kg, BC significantly lengthened PWL and reduced paw edema at all time points. No noticeable adverse effects were observed in animals given the lower dosages of BC, but adverse effects in some animals were observed at 1.80 g/kg per day. In the acute toxicity study, the maximal single dose of 2.50 g/kg produced no adverse effects in the treated rats during the 14 days of observation. Conclusions: The data suggest that BC produces significant antihyperalgesia and anti-inflammation effects and that the antihyperalgesia may be mediated by suppressed inflammation-induced Fos expression in the spinal dorsal horn neurons. © Mary Ann Liebert, Inc.en_US
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/acmen_US
dc.relation.ispartofJournal of Alternative and Complementary Medicineen_US
dc.subject.meshAnalgesics - Therapeutic Useen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animal - Drug Effectsen_US
dc.subject.meshBoswelliaen_US
dc.subject.meshFreund's Adjuvanten_US
dc.subject.meshHyperalgesia - Chemically Induced - Drug Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurogenic Inflammation - Complications - Drug Therapy - Etiologyen_US
dc.subject.meshPain Threshold - Drug Effectsen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts - Therapeutic Useen_US
dc.subject.meshProto-Oncogene Proteins C-Fos - Metabolismen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReaction Time - Drug Effectsen_US
dc.subject.meshTime Factorsen_US
dc.titleEffects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1089/acm.2005.11.323en_US
dc.identifier.pmid15865500-
dc.identifier.scopuseid_2-s2.0-18444405580en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18444405580&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue2en_US
dc.identifier.spage323en_US
dc.identifier.epage331en_US
dc.identifier.isiWOS:000229002400019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridFan, AY=7005672886en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridWang, LB=9036448600en_US
dc.identifier.scopusauthoridLee, DYW=55808069914en_US
dc.identifier.scopusauthoridMa, ZZ=8709903000en_US
dc.identifier.scopusauthoridZhang, WY=7409432776en_US
dc.identifier.scopusauthoridBerman, B=35458606800en_US

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