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Article: Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation

TitleEndogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation
Authors
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2004, v. 359 n. 1-2, p. 85-88 How to Cite?
AbstractGlucocorticoids (GC) play important roles in response to stressful stimuli, including pain. This study examined the effects of bilateral adrenalectomy (ADX) and dexamethasone (DEX) replacement on the hyperalgesia and spinal preprodynorphin (PPD) mRNA expression induced by injecting complete Freund's adjuvant (CFA) into rats' hind paws. The results demonstrated that CFA induced more intense hyperalgesia and up-expression of spinal PPD mRNA in ADX rats than in control rats, while both of these intensified reactions could be significantly suppressed by subcutaneous pretreatment with DEX. This leads to the conclusion that both exogenous (pharmacological) and endogenous (physiological) GC suppresses the behavioral hyperalgesia and the up-regulation of spinal PPD mRNA induced by sustained peripheral inflammation. The results also suggest that spinal PPD mRNA suppression may partially underlie the inhibition of behavioral hyperalgesia. © 2004 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188566
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, RXen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorQiao, JTen_US
dc.contributor.authorMalsnee, Ken_US
dc.contributor.authorRuda, MAen_US
dc.date.accessioned2013-09-03T04:10:19Z-
dc.date.available2013-09-03T04:10:19Z-
dc.date.issued2004en_US
dc.identifier.citationNeuroscience Letters, 2004, v. 359 n. 1-2, p. 85-88en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/188566-
dc.description.abstractGlucocorticoids (GC) play important roles in response to stressful stimuli, including pain. This study examined the effects of bilateral adrenalectomy (ADX) and dexamethasone (DEX) replacement on the hyperalgesia and spinal preprodynorphin (PPD) mRNA expression induced by injecting complete Freund's adjuvant (CFA) into rats' hind paws. The results demonstrated that CFA induced more intense hyperalgesia and up-expression of spinal PPD mRNA in ADX rats than in control rats, while both of these intensified reactions could be significantly suppressed by subcutaneous pretreatment with DEX. This leads to the conclusion that both exogenous (pharmacological) and endogenous (physiological) GC suppresses the behavioral hyperalgesia and the up-regulation of spinal PPD mRNA induced by sustained peripheral inflammation. The results also suggest that spinal PPD mRNA suppression may partially underlie the inhibition of behavioral hyperalgesia. © 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDynorphins - Antagonists & Inhibitors - Biosynthesisen_US
dc.subject.meshFreund's Adjuvanten_US
dc.subject.meshGlucocorticoids - Metabolism - Pharmacologyen_US
dc.subject.meshHyperalgesia - Chemically Induced - Metabolismen_US
dc.subject.meshInflammation - Chemically Induced - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshProtein Precursors - Antagonists & Inhibitors - Biosynthesisen_US
dc.subject.meshRna, Messenger - Antagonists & Inhibitors - Biosynthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord - Drug Effects - Metabolismen_US
dc.subject.meshUp-Regulation - Drug Effects - Physiologyen_US
dc.titleEndogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neulet.2004.02.014en_US
dc.identifier.pmid15050718-
dc.identifier.scopuseid_2-s2.0-1842504394en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842504394&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume359en_US
dc.identifier.issue1-2en_US
dc.identifier.spage85en_US
dc.identifier.epage88en_US
dc.identifier.isiWOS:000220768800022-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridQiao, JT=7103301572en_US
dc.identifier.scopusauthoridMalsnee, K=6506780864en_US
dc.identifier.scopusauthoridRuda, MA=7005152163en_US

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