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Article: Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation

TitleStrain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation
Authors
Issue Date2003
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2003, v. 353 n. 3, p. 213-216 How to Cite?
AbstractThe experience of pain is highly variable among individuals, which may be due in part to the effects of genetic factors on the central transmission and modulation of noxious inputs. This study examined behavioral responses and the expression of preprodynorphin (PPD) mRNA at the spinal level during complete Freund's adjuvant-induced inflammation of the unilateral hind paw in male Fischer 344 (F344), Sprague-Dawley (SD), and Lewis (LEW) rats. Experiments showed that F344 rats exhibited stronger hind paw hyperalgesia and greater spinal PPD mRNA induction than SD or LEW rats. These results indicate that genetic factors that determine the spinal PPD mRNA and dynorphin production underlie strain-dependent differences in pain perception. © 2003 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188554
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, RXen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorQiao, JTen_US
dc.contributor.authorRuda, MAen_US
dc.date.accessioned2013-09-03T04:10:15Z-
dc.date.available2013-09-03T04:10:15Z-
dc.date.issued2003en_US
dc.identifier.citationNeuroscience Letters, 2003, v. 353 n. 3, p. 213-216en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/188554-
dc.description.abstractThe experience of pain is highly variable among individuals, which may be due in part to the effects of genetic factors on the central transmission and modulation of noxious inputs. This study examined behavioral responses and the expression of preprodynorphin (PPD) mRNA at the spinal level during complete Freund's adjuvant-induced inflammation of the unilateral hind paw in male Fischer 344 (F344), Sprague-Dawley (SD), and Lewis (LEW) rats. Experiments showed that F344 rats exhibited stronger hind paw hyperalgesia and greater spinal PPD mRNA induction than SD or LEW rats. These results indicate that genetic factors that determine the spinal PPD mRNA and dynorphin production underlie strain-dependent differences in pain perception. © 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshBlotting, Northernen_US
dc.subject.meshDynorphins - Genetics - Metabolismen_US
dc.subject.meshFreund's Adjuvanten_US
dc.subject.meshInflammation - Chemically Induceden_US
dc.subject.meshMaleen_US
dc.subject.meshPain Threshold - Physiologyen_US
dc.subject.meshPeripheral Nervous System Diseases - Chemically Induced - Metabolism - Physiopathologyen_US
dc.subject.meshProtein Precursors - Genetics - Metabolismen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred F344en_US
dc.subject.meshRats, Inbred Lewen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpecies Specificityen_US
dc.subject.meshSpinal Cord - Metabolism - Physiopathologyen_US
dc.subject.meshTime Factorsen_US
dc.titleStrain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neulet.2003.09.043en_US
dc.identifier.pmid14665419-
dc.identifier.scopuseid_2-s2.0-0345528176en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0345528176&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume353en_US
dc.identifier.issue3en_US
dc.identifier.spage213en_US
dc.identifier.epage216en_US
dc.identifier.isiWOS:000187358900015-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridQiao, JT=7103301572en_US
dc.identifier.scopusauthoridRuda, MA=7005152163en_US

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