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Article: Electro-acupuncture attenuates behavioral hyperalgesia and selectively reduces spinal Fos protein expression in rats with persistent inflammation

TitleElectro-acupuncture attenuates behavioral hyperalgesia and selectively reduces spinal Fos protein expression in rats with persistent inflammation
Authors
KeywordsAcupuncture
Analgesia
Freund's Adjuvant
Pain Modulation
Issue Date2001
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jpain
Citation
Journal Of Pain, 2001, v. 2 n. 2, p. 111-117 How to Cite?
AbstractThis study examined the effect of electro-acupuncture (EA) on persistent inflammatory hyperalgesia in a rat model. Inflammation and hyperalgesia were induced by injecting complete Freund's adjuvant (CFA) into one hindpaw of the rat. Hyperalgesia was determined by a decrease in paw withdrawal latencies (PWL) to a noxious thermal stimulus. EA was applied bilaterally at the acupuncture point Huantiao (G30) at the rat's hindlimbs. EA-treated rats (n = 11) had significantly longer PWLs as compared with placebo control rats (n = 7) in the inflamed paw at 2.5 hours and 5 days after injection of CFA (P < .05) and longer PWLs as compared to sham control rats (n = 9) at 2.5 hours (P > .05). Paw edema was significantly reduced in EA-treated rats versus placebo controls at 24 hours after inflammation (P < .01). Inflammation-induced spinal Fos expression in the medial half of laminae I-II in EA-treated rats versus placebo rats (n = 5 per group) was significantly reduced (P < .01). These data showed that EA delayed the onset and facilitated the recovery of inflammatory hyperalgesia and suppressed the inflammation-induced spinal Fos expression in neurons (laminae I-II) involved in receiving noxious stimulation. This rat model of persistent pain and inflammation seems to be an ideal animal model for studying the effect of acupuncture.
Persistent Identifierhttp://hdl.handle.net/10722/188540
ISSN
2015 Impact Factor: 4.463
2015 SCImago Journal Rankings: 2.124
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLao, Len_US
dc.contributor.authorZhang, Gen_US
dc.contributor.authorWei, Fen_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorRen, Ken_US
dc.date.accessioned2013-09-03T04:10:11Z-
dc.date.available2013-09-03T04:10:11Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Pain, 2001, v. 2 n. 2, p. 111-117en_US
dc.identifier.issn1526-5900en_US
dc.identifier.urihttp://hdl.handle.net/10722/188540-
dc.description.abstractThis study examined the effect of electro-acupuncture (EA) on persistent inflammatory hyperalgesia in a rat model. Inflammation and hyperalgesia were induced by injecting complete Freund's adjuvant (CFA) into one hindpaw of the rat. Hyperalgesia was determined by a decrease in paw withdrawal latencies (PWL) to a noxious thermal stimulus. EA was applied bilaterally at the acupuncture point Huantiao (G30) at the rat's hindlimbs. EA-treated rats (n = 11) had significantly longer PWLs as compared with placebo control rats (n = 7) in the inflamed paw at 2.5 hours and 5 days after injection of CFA (P < .05) and longer PWLs as compared to sham control rats (n = 9) at 2.5 hours (P > .05). Paw edema was significantly reduced in EA-treated rats versus placebo controls at 24 hours after inflammation (P < .01). Inflammation-induced spinal Fos expression in the medial half of laminae I-II in EA-treated rats versus placebo rats (n = 5 per group) was significantly reduced (P < .01). These data showed that EA delayed the onset and facilitated the recovery of inflammatory hyperalgesia and suppressed the inflammation-induced spinal Fos expression in neurons (laminae I-II) involved in receiving noxious stimulation. This rat model of persistent pain and inflammation seems to be an ideal animal model for studying the effect of acupuncture.en_US
dc.languageengen_US
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jpainen_US
dc.relation.ispartofJournal of Painen_US
dc.subjectAcupunctureen_US
dc.subjectAnalgesiaen_US
dc.subjectFreund's Adjuvanten_US
dc.subjectPain Modulationen_US
dc.titleElectro-acupuncture attenuates behavioral hyperalgesia and selectively reduces spinal Fos protein expression in rats with persistent inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1054/jpai.2001.19575en_US
dc.identifier.pmid14622832-
dc.identifier.scopuseid_2-s2.0-0035072111en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035072111&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_US
dc.identifier.issue2en_US
dc.identifier.spage111en_US
dc.identifier.epage117en_US
dc.identifier.isiWOS:000168073500004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridZhang, G=7405269023en_US
dc.identifier.scopusauthoridWei, F=8837475400en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US

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