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Conference Paper: The acute effect of 'breaking-up' prolonged sitting on cardiovascular risk factors in overweight/obese adults

TitleThe acute effect of 'breaking-up' prolonged sitting on cardiovascular risk factors in overweight/obese adults
Authors
Issue Date2012
PublisherElsevier Australia. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/707423/description?navopenmenu=-2
Citation
The 4th International Congress on Physical Activity and Public Health (Be Active 2012), Sydney, NSW., Australia, 31 October-3 November 2012. In Journal of Science and Medicine in Sport, 2012, v. 15 suppl. 1, p. S232-S233 How to Cite?
AbstractINTRODUCTION: We have recently shown in a controlled laboratory setting that regularly ‘breaking up’ prolonged sitting with frequent short bouts of light-or moderate-intensity walking activity acutely lowers postprandial blood glucose and insulin concentrations. However, we are yet to report the effect of interrupting sitting time on secondary outcomes relating to cardiovascular disease. Consequently, we compared the effect of a single prolonged (7-hour) bout of sitting with a similar duration of sitting combined with intermittent bouts of light-intensity or moderate-intensity activity on blood pressure, blood lipids and CRP. METHODS: Overweight/obese adults (n=19; age range 45–65 yrs) were recruited for a randomized three-week, three-treatment acute cross-over trial: 1) uninterrupted sitting; 2) seated with 2-minute bouts of light-intensity walking at 3.2 km/hr every 20 minutes; and 3) seated with 2-minute bouts of moderate-intensity walking at between 5.8–6.4 km/hr every 20 minutes. Following the completion of baseline measurements and an initial 2 hour steady-state period, participants consumed a standard test meal (75 g glucose, 50 g fat). Serum triglycerides were assessed hourly to calculate the incremental area under the curve (iAUC) and high sensitivity C-reactive protein (hsCRP) was assessed at baseline and 7 hours. Seated brachial artery blood pressure was also measured every hour as a single measurement, 5 mins prior to each activity bout, with an automated oscillometric blood pressure monitor (Philips SureSigns VS3 Monitor). GEE models were adjusted for sex, age, BMI, fasting blood pressure and treatment order. RESULTS: Systolic blood pressure decreased similarly and significantly during the light and moderate-intensity activity conditions [light: 120±4mmHg (hourly mean±SEM), p=0.002; moderate: 120±3mmHg, p=0.02] compared to uninterrupted sitting (125±4mmHg). Diastolic blood pressure was also significantly reduced with both activity conditions (light: 78±3mmHg, p=0.006; moderate: 78±3mmHg, p=0.03) compared to uninterrupted sitting (79±3mmHg). No significant group differences were observed in triglyceride iAUC, hsCRP and the hourly measurement of heart rate. DISCUSSION: These findings indicate that breaking up prolonged sitting with frequent short breaks of either light or moderate-intensity physical activity may have favourable effects on seated blood pressure. Further studies are needed to evaluate the chronic effects of breaking up sedentary time on cardiovascular disease risk factors and the feasibility of such strategies in the general community.
DescriptionSession - Physical activity and cardiovascular disease in adults: paper no. 562
This journal suppl. entitled: Be Avtive 2012
Persistent Identifierhttp://hdl.handle.net/10722/188039
ISSN
2015 Impact Factor: 3.756
2015 SCImago Journal Rankings: 1.484

 

DC FieldValueLanguage
dc.contributor.authorLarsen, Ren_US
dc.contributor.authorKingwell, Ben_US
dc.contributor.authorRobinson, Cen_US
dc.contributor.authorHealy, Gen_US
dc.contributor.authorSethi, Pen_US
dc.contributor.authorCerin, Een_US
dc.contributor.authorOwen, Nen_US
dc.contributor.authorDunstan, Den_US
dc.date.accessioned2013-08-21T07:26:48Z-
dc.date.available2013-08-21T07:26:48Z-
dc.date.issued2012en_US
dc.identifier.citationThe 4th International Congress on Physical Activity and Public Health (Be Active 2012), Sydney, NSW., Australia, 31 October-3 November 2012. In Journal of Science and Medicine in Sport, 2012, v. 15 suppl. 1, p. S232-S233en_US
dc.identifier.issn1440-2440-
dc.identifier.urihttp://hdl.handle.net/10722/188039-
dc.descriptionSession - Physical activity and cardiovascular disease in adults: paper no. 562-
dc.descriptionThis journal suppl. entitled: Be Avtive 2012-
dc.description.abstractINTRODUCTION: We have recently shown in a controlled laboratory setting that regularly ‘breaking up’ prolonged sitting with frequent short bouts of light-or moderate-intensity walking activity acutely lowers postprandial blood glucose and insulin concentrations. However, we are yet to report the effect of interrupting sitting time on secondary outcomes relating to cardiovascular disease. Consequently, we compared the effect of a single prolonged (7-hour) bout of sitting with a similar duration of sitting combined with intermittent bouts of light-intensity or moderate-intensity activity on blood pressure, blood lipids and CRP. METHODS: Overweight/obese adults (n=19; age range 45–65 yrs) were recruited for a randomized three-week, three-treatment acute cross-over trial: 1) uninterrupted sitting; 2) seated with 2-minute bouts of light-intensity walking at 3.2 km/hr every 20 minutes; and 3) seated with 2-minute bouts of moderate-intensity walking at between 5.8–6.4 km/hr every 20 minutes. Following the completion of baseline measurements and an initial 2 hour steady-state period, participants consumed a standard test meal (75 g glucose, 50 g fat). Serum triglycerides were assessed hourly to calculate the incremental area under the curve (iAUC) and high sensitivity C-reactive protein (hsCRP) was assessed at baseline and 7 hours. Seated brachial artery blood pressure was also measured every hour as a single measurement, 5 mins prior to each activity bout, with an automated oscillometric blood pressure monitor (Philips SureSigns VS3 Monitor). GEE models were adjusted for sex, age, BMI, fasting blood pressure and treatment order. RESULTS: Systolic blood pressure decreased similarly and significantly during the light and moderate-intensity activity conditions [light: 120±4mmHg (hourly mean±SEM), p=0.002; moderate: 120±3mmHg, p=0.02] compared to uninterrupted sitting (125±4mmHg). Diastolic blood pressure was also significantly reduced with both activity conditions (light: 78±3mmHg, p=0.006; moderate: 78±3mmHg, p=0.03) compared to uninterrupted sitting (79±3mmHg). No significant group differences were observed in triglyceride iAUC, hsCRP and the hourly measurement of heart rate. DISCUSSION: These findings indicate that breaking up prolonged sitting with frequent short breaks of either light or moderate-intensity physical activity may have favourable effects on seated blood pressure. Further studies are needed to evaluate the chronic effects of breaking up sedentary time on cardiovascular disease risk factors and the feasibility of such strategies in the general community.-
dc.languageengen_US
dc.publisherElsevier Australia. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/707423/description?navopenmenu=-2-
dc.relation.ispartofJournal of Science and Medicine in Sporten_US
dc.titleThe acute effect of 'breaking-up' prolonged sitting on cardiovascular risk factors in overweight/obese adultsen_US
dc.typeConference_Paperen_US
dc.identifier.emailCerin, E: ecerin@hku.hken_US
dc.identifier.authorityCerin, E=rp00890en_US
dc.identifier.hkuros218473en_US
dc.identifier.volume15-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS232-
dc.identifier.epageS233-
dc.publisher.placeAustralia-

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