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Conference Paper: Maternal green tea extract supplementation ameliorates insulin resistance in male offspring from dams fed a high-fat diet

TitleMaternal green tea extract supplementation ameliorates insulin resistance in male offspring from dams fed a high-fat diet
Authors
KeywordsBiology
Issue Date2010
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Experimental Biology 2010, Anaheim, CA., 24-28 April 2010. In The FASEB Journal, 2010, v. 24 meeting abstracts, no. 344.6 How to Cite?
AbstractGreen tea (GT) possesses beneficial effects against obesity and insulin resistance (IR). This study aimed to test the hypothesis that maternal green tea supplementation alleviates metabolic derangements in offspring born from obese dams. Female SD rats were fed a low-fat (LF), high-fat (HF), 0.75% or 1.0% GT extract added HF diet (HT1, HT2) from 8 wk before mating until end of lactation. GT dams tended to gain less during gestation but birth weight and litter size were not affected. There were 6 dam/pup diet groups: LF/HF, HF/HF, HF/HT1, HF/HT2, HT1/HF and HT2/HF. On d21 postpartum, GT dams had less visceral fat and lower insulin level than HF dams (n=8, p < 0.05). Body weight of pups from GT dams on d21 were lower (p < 0.05), but not on d91 than from HF dams. On d91, HT1/HF and HT2/HF rats had lower IR index than HF/HF and HF/HT1 rats (n=7–9, p < 0.02). Rats from GT dams had higher expression of uncoupling protein 1 in brown adipose tissue; adiponectin in adipocytes and peroxisome proliferator-activated receptor-gamma coactivator-1 alpha in gastrocnemius but lower expression of hepatic glucose-6-phosphatase than HF/HF rats (p < 0.05). Hence, offspring of GT dams had better glucose handling and insulin sensitivity, and maternal exposure is more effective than postnatal GT supplementation. These results highlight the potential impact of dietary bioactive compounds on fetal development via metabolic programming.
Persistent Identifierhttp://hdl.handle.net/10722/188018
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorLi, Sen_US
dc.contributor.authorLi, ETSen_US
dc.date.accessioned2013-08-21T07:24:55Z-
dc.date.available2013-08-21T07:24:55Z-
dc.date.issued2010en_US
dc.identifier.citationExperimental Biology 2010, Anaheim, CA., 24-28 April 2010. In The FASEB Journal, 2010, v. 24 meeting abstracts, no. 344.6en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/188018-
dc.description.abstractGreen tea (GT) possesses beneficial effects against obesity and insulin resistance (IR). This study aimed to test the hypothesis that maternal green tea supplementation alleviates metabolic derangements in offspring born from obese dams. Female SD rats were fed a low-fat (LF), high-fat (HF), 0.75% or 1.0% GT extract added HF diet (HT1, HT2) from 8 wk before mating until end of lactation. GT dams tended to gain less during gestation but birth weight and litter size were not affected. There were 6 dam/pup diet groups: LF/HF, HF/HF, HF/HT1, HF/HT2, HT1/HF and HT2/HF. On d21 postpartum, GT dams had less visceral fat and lower insulin level than HF dams (n=8, p < 0.05). Body weight of pups from GT dams on d21 were lower (p < 0.05), but not on d91 than from HF dams. On d91, HT1/HF and HT2/HF rats had lower IR index than HF/HF and HF/HT1 rats (n=7–9, p < 0.02). Rats from GT dams had higher expression of uncoupling protein 1 in brown adipose tissue; adiponectin in adipocytes and peroxisome proliferator-activated receptor-gamma coactivator-1 alpha in gastrocnemius but lower expression of hepatic glucose-6-phosphatase than HF/HF rats (p < 0.05). Hence, offspring of GT dams had better glucose handling and insulin sensitivity, and maternal exposure is more effective than postnatal GT supplementation. These results highlight the potential impact of dietary bioactive compounds on fetal development via metabolic programming.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.subjectBiology-
dc.titleMaternal green tea extract supplementation ameliorates insulin resistance in male offspring from dams fed a high-fat dieten_US
dc.typeConference_Paperen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros220275en_US
dc.identifier.volume24-
dc.identifier.issuemeeting abstracts-
dc.publisher.placeUnited States-

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