File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Natural phenolics from the twigs of Cudrania tricuspidata as hypopigmenting agents against melanogenesis in B16 and melan-a cell line and their mechanisms of action

TitleNatural phenolics from the twigs of Cudrania tricuspidata as hypopigmenting agents against melanogenesis in B16 and melan-a cell line and their mechanisms of action
Authors
Issue Date2013
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1755-1471&site=1
Citation
The 2013 Joint Conference of the Asian Society for Pigment Cell Research (ASPCR) and the Australasian Society for Dermatology Research (ASDR), Sydney, Australia, 17-19 May 2013. In Pigment Cell & Melanoma Research, 2013, v. 26 n. 3, p. E9 How to Cite?
AbstractIn East Asian culture, lighter skin tone is more preferable among the female population. Moreover, irregular hyperpigmentations such as solar Lentigines, melasma, and freckles are of concern in both Asia and western countries. Due to the high demand and potential for skin whitening products, the search for safe and effective depigmenting agents has become a popular research area. Hypopigmentation agents, also known as skin-whitening agents, are widely used to lighten the skin tone or treat abnormal hyperpigmentation by inhibiting the melanogenesis process. Cudrania tricuspidata, a deciduous tree growing in East Asia, is rich in isoprenylated xanthones and flavonoids. According to the previous research from our laboratory, oxyresveratrol and trans-dihydromorin purified from the twigs of Cudrania tricuspidata, are potent mushroom tyrosinase inhibitors, and may effectively inhibit the melanogenesis process in melanocyte. In this study, two cell cultures are exploited: B16 cell and melan-a cell. B16 murine cell line is selected as it is widely used in current research for the search of melanogenesis inhibitors. However, as B16 cells are highly metastatic tumor cells, a normal epidermal cell-based system should also be considered. Thus, Melan-a cell line, a normal epidermal melanocyte is utilized. The hypopigmenting effects of oxyresveratrol and transdihydromorin in these two cell lines are evaluated by measuring the melanin content in SRB assay. Their mechanisms of action are also identified by examining the inhibitory effects on cellular tyrosinase activity, l-dopa oxidative activity, as well as the related gene mRNA expression and protein expression.
DescriptionPages E1–E27 of this journal issue contain Free Abstracts of ASPCR-ASDR 2013
Persistent Identifierhttp://hdl.handle.net/10722/188008
ISSN
2015 Impact Factor: 4.163
2015 SCImago Journal Rankings: 2.273

 

DC FieldValueLanguage
dc.contributor.authorHu, Sen_US
dc.contributor.authorChen, SFen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2013-08-21T07:24:48Z-
dc.date.available2013-08-21T07:24:48Z-
dc.date.issued2013en_US
dc.identifier.citationThe 2013 Joint Conference of the Asian Society for Pigment Cell Research (ASPCR) and the Australasian Society for Dermatology Research (ASDR), Sydney, Australia, 17-19 May 2013. In Pigment Cell & Melanoma Research, 2013, v. 26 n. 3, p. E9en_US
dc.identifier.issn1755-1471-
dc.identifier.urihttp://hdl.handle.net/10722/188008-
dc.descriptionPages E1–E27 of this journal issue contain Free Abstracts of ASPCR-ASDR 2013-
dc.description.abstractIn East Asian culture, lighter skin tone is more preferable among the female population. Moreover, irregular hyperpigmentations such as solar Lentigines, melasma, and freckles are of concern in both Asia and western countries. Due to the high demand and potential for skin whitening products, the search for safe and effective depigmenting agents has become a popular research area. Hypopigmentation agents, also known as skin-whitening agents, are widely used to lighten the skin tone or treat abnormal hyperpigmentation by inhibiting the melanogenesis process. Cudrania tricuspidata, a deciduous tree growing in East Asia, is rich in isoprenylated xanthones and flavonoids. According to the previous research from our laboratory, oxyresveratrol and trans-dihydromorin purified from the twigs of Cudrania tricuspidata, are potent mushroom tyrosinase inhibitors, and may effectively inhibit the melanogenesis process in melanocyte. In this study, two cell cultures are exploited: B16 cell and melan-a cell. B16 murine cell line is selected as it is widely used in current research for the search of melanogenesis inhibitors. However, as B16 cells are highly metastatic tumor cells, a normal epidermal cell-based system should also be considered. Thus, Melan-a cell line, a normal epidermal melanocyte is utilized. The hypopigmenting effects of oxyresveratrol and transdihydromorin in these two cell lines are evaluated by measuring the melanin content in SRB assay. Their mechanisms of action are also identified by examining the inhibitory effects on cellular tyrosinase activity, l-dopa oxidative activity, as well as the related gene mRNA expression and protein expression.-
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1755-1471&site=1-
dc.relation.ispartofPigment Cell & Melanoma Researchen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.titleNatural phenolics from the twigs of Cudrania tricuspidata as hypopigmenting agents against melanogenesis in B16 and melan-a cell line and their mechanisms of actionen_US
dc.typeConference_Paperen_US
dc.identifier.emailChen, SF: sfchen@hku.hken_US
dc.identifier.emailWang, M: mfwang@hku.hken_US
dc.identifier.authorityChen, SF=rp00672en_US
dc.identifier.authorityWang, M=rp00800en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/pcmr.12094-
dc.identifier.hkuros219648en_US
dc.identifier.volume26-
dc.identifier.issue3-
dc.identifier.spageE9-
dc.identifier.epageE9-
dc.publisher.placeUnited Statesen_US
dc.customcontrol.immutablesml 131008-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats