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Article: Receptor oligomerization: from early evidence to current understanding in class B GPCRs

TitleReceptor oligomerization: from early evidence to current understanding in class B GPCRs
Authors
Issue Date2013
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/endocrinology/
Citation
Frontiers in Endocrinology, 2013, v. 3, article no. 175 How to Cite?
AbstractDimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, among others. The functional implications of receptor dimerization have extensively been studied in class A GPCRs, while less is known regarding its function in class B GPCRs. This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs.
Persistent Identifierhttp://hdl.handle.net/10722/187748
ISSN
2015 SCImago Journal Rankings: 1.824
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorNg, SYLen_US
dc.contributor.authorLee, TOen_US
dc.contributor.authorChow, BKCen_US
dc.date.accessioned2013-08-21T07:11:58Z-
dc.date.available2013-08-21T07:11:58Z-
dc.date.issued2013en_US
dc.identifier.citationFrontiers in Endocrinology, 2013, v. 3, article no. 175en_US
dc.identifier.issn1664-2392en_US
dc.identifier.urihttp://hdl.handle.net/10722/187748-
dc.description.abstractDimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, among others. The functional implications of receptor dimerization have extensively been studied in class A GPCRs, while less is known regarding its function in class B GPCRs. This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs.en_US
dc.languageengen_US
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/endocrinology/en_US
dc.relation.ispartofFrontiers in Endocrinologyen_US
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleReceptor oligomerization: from early evidence to current understanding in class B GPCRsen_US
dc.typeArticleen_US
dc.identifier.emailNg, SYL: ngyls@hku.hken_US
dc.identifier.emailLee, TO: ltolee2@hkucc.hku.hken_US
dc.identifier.emailChow, BKC: bkcc@hku.hken_US
dc.identifier.authorityLee, TO=rp00727en_US
dc.identifier.authorityChow, BKC=rp00681en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.3389/fendo.2012.00175en_US
dc.identifier.pmid23316183en_US
dc.identifier.pmcidPMC3539651en_US
dc.identifier.scopuseid_2-s2.0-84874275263-
dc.identifier.hkuros220043en_US
dc.identifier.hkuros229175-
dc.identifier.volume3en_US
dc.publisher.placeSwitzerlanden_US

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