File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: p70 S6 kinase and actin dynamics: A perspective

Titlep70 S6 kinase and actin dynamics: A perspective
Authors
Keywordsp70 S6 kinase
Cancer
Actin
Rac1
Cdc42
Testis
Spermatogenesis
Germ cell
Issue Date2012
PublisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/spermatogenesis/
Citation
Spermatogenesis, 2012, v. 2 n. 1, p. 44-52 How to Cite?
Abstractp70 S6 kinase (p70(S6K)), a member of the AGC serine/threonine kinase family, was initially identified as a key player, together with its downstream effector S6, in the regulation of cellular growth and survival. The p70(S6K) protein has emerged in recent years as a multifunctional protein which also regulates the actin cytoskeleton and thus plays a role in cell migration. This new function is through two important activities of p70(S6K), namely actin cross-linking and Rac1 and Cdc42 activation. The testis is critically dependent on an intricate balance of fundamental cellular processes such as adhesion, migration, and differentiation. It is increasingly evident that Rho GTPases and actin binding proteins play fundamental roles in regulating spermatogenesis within the testis. In this review, we will discuss current findings of p70(S6K) in the control of actin cytoskeleton dynamics. In addition, the potential role of p70(S6K) in spermatogenesis and testicular function will be highlighted.
Persistent Identifierhttp://hdl.handle.net/10722/187727
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorIp, CKMen_US
dc.contributor.authorWong, ASTen_US
dc.date.accessioned2013-08-21T07:11:47Z-
dc.date.available2013-08-21T07:11:47Z-
dc.date.issued2012en_US
dc.identifier.citationSpermatogenesis, 2012, v. 2 n. 1, p. 44-52en_US
dc.identifier.issn2156-5554en_US
dc.identifier.urihttp://hdl.handle.net/10722/187727-
dc.description.abstractp70 S6 kinase (p70(S6K)), a member of the AGC serine/threonine kinase family, was initially identified as a key player, together with its downstream effector S6, in the regulation of cellular growth and survival. The p70(S6K) protein has emerged in recent years as a multifunctional protein which also regulates the actin cytoskeleton and thus plays a role in cell migration. This new function is through two important activities of p70(S6K), namely actin cross-linking and Rac1 and Cdc42 activation. The testis is critically dependent on an intricate balance of fundamental cellular processes such as adhesion, migration, and differentiation. It is increasingly evident that Rho GTPases and actin binding proteins play fundamental roles in regulating spermatogenesis within the testis. In this review, we will discuss current findings of p70(S6K) in the control of actin cytoskeleton dynamics. In addition, the potential role of p70(S6K) in spermatogenesis and testicular function will be highlighted.en_US
dc.languageengen_US
dc.publisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/spermatogenesis/en_US
dc.relation.ispartofSpermatogenesisen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectp70 S6 kinase-
dc.subjectCancer-
dc.subjectActin-
dc.subjectRac1-
dc.subjectCdc42-
dc.subjectTestis-
dc.subjectSpermatogenesis-
dc.subjectGerm cell-
dc.titlep70 S6 kinase and actin dynamics: A perspectiveen_US
dc.typeArticleen_US
dc.identifier.emailIp, CKM: carmanip@hku.hken_US
dc.identifier.emailWong, AST: awong1@hkucc.hku.hken_US
dc.identifier.authorityWong, AST=rp00805en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.4161/spmg.19413en_US
dc.identifier.pmid22553489en_US
dc.identifier.pmcidPMC3341245en_US
dc.identifier.hkuros218055en_US
dc.identifier.volume2en_US
dc.identifier.issue1en_US
dc.identifier.spage44en_US
dc.identifier.epage52en_US
dc.publisher.placeUnited Statesen_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats