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Book Chapter: Ketamine

TitleKetamine
Authors
KeywordsKetamine
Central nervous system
Liver
Kidney
Gastrointestinal system
Issue Date2013
PublisherElsevier/Academic Press
Citation
Ketamine. In Dargan, PI & Wood, DM (Eds.), Novel psychoactive substances: classification, pharmacology and toxicology, p. 285-316. London; Waltham, MA: Elsevier/Academic Press, 2013 How to Cite?
AbstractKetamine was introduced as an anaesthetic in the 1960s and continues to be used therapeutically both as an anaesthetic and also increasingly in pain management. In addition to use in humans, ketamine is widely used as an anaesthetic in veterinary medicine. It is used in research as a pharmacological model of schizophrenia. In recent years, ketamine has increasingly been used as a recreational drug. Though it is now a controlled substance in many countries in the world due to its psychotropic properties, its use as a recreational drug has become a worldwide phenomenon. In addition to the risk of acute toxicity associated with ketamine use, long-term ketamine toxicity can produce significant adverse effects and consequently lead to a burden on healthcare resources. In this chapter, we summarize the pathological changes in the different organs of animal models and humans, including its toxicity on central nervous system (CNS), urogenital system, intestine, pancreas, adrenal gland, liver, heart and immune system. The effects on the combination of ketamine and alcohol were also addressed in a number of the models of chronic ketamine toxicity. This is followed by a summary of the human data on patterns of acute and chronic toxicity reported from recreational and dependent use of ketamine.
Persistent Identifierhttp://hdl.handle.net/10722/187466
ISBN

 

DC FieldValueLanguage
dc.contributor.authorLi, Qen_US
dc.contributor.authorChan, WMen_US
dc.contributor.authorRudd, JAen_US
dc.contributor.authorWang, CMen_US
dc.contributor.authorLam, PYHen_US
dc.contributor.authorWai, MSMen_US
dc.contributor.authorWood, DMen_US
dc.contributor.authorDargan, PIen_US
dc.contributor.authorYew, DTen_US
dc.date.accessioned2013-08-20T12:48:23Z-
dc.date.available2013-08-20T12:48:23Z-
dc.date.issued2013en_US
dc.identifier.citationKetamine. In Dargan, PI & Wood, DM (Eds.), Novel psychoactive substances: classification, pharmacology and toxicology, p. 285-316. London; Waltham, MA: Elsevier/Academic Press, 2013en_US
dc.identifier.isbn9780124158160en_US
dc.identifier.urihttp://hdl.handle.net/10722/187466-
dc.description.abstractKetamine was introduced as an anaesthetic in the 1960s and continues to be used therapeutically both as an anaesthetic and also increasingly in pain management. In addition to use in humans, ketamine is widely used as an anaesthetic in veterinary medicine. It is used in research as a pharmacological model of schizophrenia. In recent years, ketamine has increasingly been used as a recreational drug. Though it is now a controlled substance in many countries in the world due to its psychotropic properties, its use as a recreational drug has become a worldwide phenomenon. In addition to the risk of acute toxicity associated with ketamine use, long-term ketamine toxicity can produce significant adverse effects and consequently lead to a burden on healthcare resources. In this chapter, we summarize the pathological changes in the different organs of animal models and humans, including its toxicity on central nervous system (CNS), urogenital system, intestine, pancreas, adrenal gland, liver, heart and immune system. The effects on the combination of ketamine and alcohol were also addressed in a number of the models of chronic ketamine toxicity. This is followed by a summary of the human data on patterns of acute and chronic toxicity reported from recreational and dependent use of ketamine.-
dc.languageengen_US
dc.publisherElsevier/Academic Pressen_US
dc.relation.ispartofNovel psychoactive substances: classification, pharmacology and toxicologyen_US
dc.subjectKetamine-
dc.subjectCentral nervous system-
dc.subjectLiver-
dc.subjectKidney-
dc.subjectGastrointestinal system-
dc.titleKetamineen_US
dc.typeBook_Chapteren_US
dc.identifier.emailLi, Q: liqi@hkucc.hku.hken_US
dc.identifier.doi10.1016/B978-0-12-415816-0.00012-2-
dc.identifier.hkuros217891en_US
dc.identifier.spage285-
dc.identifier.epage316-
dc.publisher.placeLondon; Waltham, MA-

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