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Conference Paper: Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection
Title | Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection |
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Authors | |
Keywords | Medical sciences Oncology |
Issue Date | 2013 |
Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
Citation | The 104th Annual Meeting of the American Association for Cancer Research (AACR 2013), Washington, DC, PA., 6-10 April 2013. In Cancer Research, 2013, v. 73 n. 8, suppl. 1, abstract no. 4784 How to Cite? |
Abstract | EBV infection is closely associated with nasopharyngeal carcinoma. Early events involved in the establishment of EBV infection in premalignant nasopharyngeal epithelium are largely undefined. We have established multiple immortalized nasopharygeal epithelial cells as premalignant cell models for EBV infection. We observed that nasopharyngeal epithelial cells immortalized by combined actions of telomerase and cyclin D1 or knocking down p16 could support stable EBV infection. Furthermore, we observed that EBV infection commonly induces growth inhibition and senescence in infected nasopharyngeal epithelial cells. Overexpression of cyclin D1 suppresses the growth inhibition and support EBV infection. Furthermore cyclin D1 expression confers ... |
Description | Poster Presentations - Transformation and Promotion: abstract no. 4784 |
Persistent Identifier | http://hdl.handle.net/10722/186566 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tsao, GSW | en_US |
dc.contributor.author | Tsang, ACM | en_US |
dc.contributor.author | Yip, EYL | en_US |
dc.contributor.author | Deng, W | en_US |
dc.contributor.author | Cheung, ALM | en_US |
dc.contributor.author | Lo, KW | en_US |
dc.date.accessioned | 2013-08-20T12:13:28Z | - |
dc.date.available | 2013-08-20T12:13:28Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 104th Annual Meeting of the American Association for Cancer Research (AACR 2013), Washington, DC, PA., 6-10 April 2013. In Cancer Research, 2013, v. 73 n. 8, suppl. 1, abstract no. 4784 | en_US |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/186566 | - |
dc.description | Poster Presentations - Transformation and Promotion: abstract no. 4784 | - |
dc.description.abstract | EBV infection is closely associated with nasopharyngeal carcinoma. Early events involved in the establishment of EBV infection in premalignant nasopharyngeal epithelium are largely undefined. We have established multiple immortalized nasopharygeal epithelial cells as premalignant cell models for EBV infection. We observed that nasopharyngeal epithelial cells immortalized by combined actions of telomerase and cyclin D1 or knocking down p16 could support stable EBV infection. Furthermore, we observed that EBV infection commonly induces growth inhibition and senescence in infected nasopharyngeal epithelial cells. Overexpression of cyclin D1 suppresses the growth inhibition and support EBV infection. Furthermore cyclin D1 expression confers ... | - |
dc.language | eng | en_US |
dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | - |
dc.relation.ispartof | Cancer Research | en_US |
dc.subject | Medical sciences | - |
dc.subject | Oncology | - |
dc.title | Genetic alterations in premalignant nasopharyngeal epithelium support stable EBV infection | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Tsao, GSW: gswtsao@hku.hk | en_US |
dc.identifier.email | Tsang, ACM: annatsan@hku.hk | en_US |
dc.identifier.email | Yip, EYL: yimling@hkucc.hku.hk | en_US |
dc.identifier.email | Deng, W: wdeng@hkucc.hku.hk | en_US |
dc.identifier.email | Cheung, ALM: lmcheung@hku.hk | en_US |
dc.identifier.authority | Tsao, GSW=rp00399 | en_US |
dc.identifier.authority | Deng, W=rp01640 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1158/1538-7445.AM2013-4784 | - |
dc.identifier.hkuros | 217527 | en_US |
dc.identifier.volume | 73 | - |
dc.identifier.issue | 8, suppl. 1 | - |
dc.identifier.isi | WOS:000331220604346 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0008-5472 | - |