File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Synergistic effect of proanthocyanidin and CPP-ACFP on root caries remineralisation
Title | Synergistic effect of proanthocyanidin and CPP-ACFP on root caries remineralisation |
---|---|
Authors | |
Keywords | Caries Proanthocyanidin Remineralization and Root |
Issue Date | 2013 |
Publisher | Sage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925 |
Citation | The 91st General Session General Session & Exhibition of the International Association for Dental Research (IADR), Seattle, Washington, USA, 20-23 March 2013. In Journal of Dental Research, 2013, v. 92, Special Issue A, abstract no. 777 How to Cite? |
Abstract | Objective: Root caries remains a major oral health problem among the elderly. Proanthocyanidin (PA) has shown positive effects on remineralization of artificial root caries. It is advantageous to find methods to enhance the remineralization effect of PA. This study evaluated the synergistic effect of PA and casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) on remineralization of artificial root caries.
Method: Demineralized root fragments (n=90) were randomly divided into six groups based on treatments: (i) 6.5% PA, (ii) CPP-ACP, (iii) CPP-ACFP, (iv) CPP-ACFP + 6.5% PA, (v) 1000ppm fluoride and (vi) deionized water (control). Each specimen was immersed in the demineralizing solution for 14 h, testing solutions/pastes for 2 h and remineralizing solution for 8 h. The pH cycling was performed at 37oC for 8 days. Specimens were evaluated using transverse microradiography (lesion depth and mineral loss), a microhardness tester (Knoop hardness) and confocal laser scanning microscopy (CLSM). The lesion depth and mineral loss were analyzed using one-way ANOVA; while microhardness were analyzed with two-way ANOVA and Tukey’s test.
Result: One-way ANOVA indicated that testing solutions had a significant effect on lesion depth (P<0.05) and mineral loss (P<0.05). Lesion depth was significantly lower in CPP-ACFP+PA and 1000ppm fluoride groups (P<0.05). Mineral loss was the lowest in CPP-ACFP+PA group (P<0.05). Two-way ANOVA indicated that the factors “testing solutions/pastes” and “lesion depth” had a significant effect on Knoop hardness (P<0.05), with interaction between the two factors (P<0.05). Artificial caries lesions treated with CPP-ACFP+PA showed significantly higher microhardness values at 130μm and 150 μm from the surface (P<0.05). Remineralizing bands with higher mineral density were observed in CPP-ACFP+PA group.
Conclusion: The combined use of proanthocyanidin and casein phosphopeptide amorphous calcium fluoride phosphate has a synergistic effect on root caries remineralization by enhancing mineral gain and increasing hardness of the artificial root caries. |
Description | Poster Session: Dentin Morphology, Occlusion, Remineralization |
Persistent Identifier | http://hdl.handle.net/10722/186510 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.909 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Epasinghe, DJ | en_US |
dc.contributor.author | Yiu, CKY | en_US |
dc.contributor.author | Burrow, MF | en_US |
dc.date.accessioned | 2013-08-20T12:12:10Z | - |
dc.date.available | 2013-08-20T12:12:10Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 91st General Session General Session & Exhibition of the International Association for Dental Research (IADR), Seattle, Washington, USA, 20-23 March 2013. In Journal of Dental Research, 2013, v. 92, Special Issue A, abstract no. 777 | en_US |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | http://hdl.handle.net/10722/186510 | - |
dc.description | Poster Session: Dentin Morphology, Occlusion, Remineralization | - |
dc.description.abstract | Objective: Root caries remains a major oral health problem among the elderly. Proanthocyanidin (PA) has shown positive effects on remineralization of artificial root caries. It is advantageous to find methods to enhance the remineralization effect of PA. This study evaluated the synergistic effect of PA and casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) on remineralization of artificial root caries. Method: Demineralized root fragments (n=90) were randomly divided into six groups based on treatments: (i) 6.5% PA, (ii) CPP-ACP, (iii) CPP-ACFP, (iv) CPP-ACFP + 6.5% PA, (v) 1000ppm fluoride and (vi) deionized water (control). Each specimen was immersed in the demineralizing solution for 14 h, testing solutions/pastes for 2 h and remineralizing solution for 8 h. The pH cycling was performed at 37oC for 8 days. Specimens were evaluated using transverse microradiography (lesion depth and mineral loss), a microhardness tester (Knoop hardness) and confocal laser scanning microscopy (CLSM). The lesion depth and mineral loss were analyzed using one-way ANOVA; while microhardness were analyzed with two-way ANOVA and Tukey’s test. Result: One-way ANOVA indicated that testing solutions had a significant effect on lesion depth (P<0.05) and mineral loss (P<0.05). Lesion depth was significantly lower in CPP-ACFP+PA and 1000ppm fluoride groups (P<0.05). Mineral loss was the lowest in CPP-ACFP+PA group (P<0.05). Two-way ANOVA indicated that the factors “testing solutions/pastes” and “lesion depth” had a significant effect on Knoop hardness (P<0.05), with interaction between the two factors (P<0.05). Artificial caries lesions treated with CPP-ACFP+PA showed significantly higher microhardness values at 130μm and 150 μm from the surface (P<0.05). Remineralizing bands with higher mineral density were observed in CPP-ACFP+PA group. Conclusion: The combined use of proanthocyanidin and casein phosphopeptide amorphous calcium fluoride phosphate has a synergistic effect on root caries remineralization by enhancing mineral gain and increasing hardness of the artificial root caries. | - |
dc.language | eng | en_US |
dc.publisher | Sage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925 | - |
dc.relation.ispartof | Journal of Dental Research | en_US |
dc.rights | Journal of Dental Research. Copyright © Sage Publications, Inc.. | - |
dc.subject | Caries | - |
dc.subject | Proanthocyanidin | - |
dc.subject | Remineralization and Root | - |
dc.title | Synergistic effect of proanthocyanidin and CPP-ACFP on root caries remineralisation | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Yiu, CKY: ckyyiu@hkucc.hku.hk | en_US |
dc.identifier.email | Burrow, MF: mfburr58@hku.hk | en_US |
dc.identifier.authority | Yiu, CKY=rp00018 | en_US |
dc.identifier.authority | Burrow, MF=rp01306 | en_US |
dc.identifier.hkuros | 216888 | en_US |
dc.identifier.volume | 92 | - |
dc.identifier.issue | Special Issue A | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-0345 | - |