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Conference Paper: Synergistic effect of proanthocyanidin and CPP-ACFP on root caries remineralisation

TitleSynergistic effect of proanthocyanidin and CPP-ACFP on root caries remineralisation
Authors
KeywordsCaries
Proanthocyanidin
Remineralization and Root
Issue Date2013
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
The 91st General Session General Session & Exhibition of the International Association for Dental Research (IADR), Seattle, Washington, USA, 20-23 March 2013. In Journal of Dental Research, 2013, v. 92, Special Issue A, abstract no. 777 How to Cite?
AbstractObjective: Root caries remains a major oral health problem among the elderly. Proanthocyanidin (PA) has shown positive effects on remineralization of artificial root caries. It is advantageous to find methods to enhance the remineralization effect of PA. This study evaluated the synergistic effect of PA and casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) on remineralization of artificial root caries. Method: Demineralized root fragments (n=90) were randomly divided into six groups based on treatments: (i) 6.5% PA, (ii) CPP-ACP, (iii) CPP-ACFP, (iv) CPP-ACFP + 6.5% PA, (v) 1000ppm fluoride and (vi) deionized water (control). Each specimen was immersed in the demineralizing solution for 14 h, testing solutions/pastes for 2 h and remineralizing solution for 8 h. The pH cycling was performed at 37oC for 8 days. Specimens were evaluated using transverse microradiography (lesion depth and mineral loss), a microhardness tester (Knoop hardness) and confocal laser scanning microscopy (CLSM). The lesion depth and mineral loss were analyzed using one-way ANOVA; while microhardness were analyzed with two-way ANOVA and Tukey’s test. Result: One-way ANOVA indicated that testing solutions had a significant effect on lesion depth (P<0.05) and mineral loss (P<0.05). Lesion depth was significantly lower in CPP-ACFP+PA and 1000ppm fluoride groups (P<0.05). Mineral loss was the lowest in CPP-ACFP+PA group (P<0.05). Two-way ANOVA indicated that the factors “testing solutions/pastes” and “lesion depth” had a significant effect on Knoop hardness (P<0.05), with interaction between the two factors (P<0.05). Artificial caries lesions treated with CPP-ACFP+PA showed significantly higher microhardness values at 130μm and 150 μm from the surface (P<0.05). Remineralizing bands with higher mineral density were observed in CPP-ACFP+PA group. Conclusion: The combined use of proanthocyanidin and casein phosphopeptide amorphous calcium fluoride phosphate has a synergistic effect on root caries remineralization by enhancing mineral gain and increasing hardness of the artificial root caries.
DescriptionPoster Session: Dentin Morphology, Occlusion, Remineralization
Persistent Identifierhttp://hdl.handle.net/10722/186510
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorEpasinghe, DJen_US
dc.contributor.authorYiu, CKYen_US
dc.contributor.authorBurrow, MFen_US
dc.date.accessioned2013-08-20T12:12:10Z-
dc.date.available2013-08-20T12:12:10Z-
dc.date.issued2013en_US
dc.identifier.citationThe 91st General Session General Session & Exhibition of the International Association for Dental Research (IADR), Seattle, Washington, USA, 20-23 March 2013. In Journal of Dental Research, 2013, v. 92, Special Issue A, abstract no. 777en_US
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/186510-
dc.descriptionPoster Session: Dentin Morphology, Occlusion, Remineralization-
dc.description.abstractObjective: Root caries remains a major oral health problem among the elderly. Proanthocyanidin (PA) has shown positive effects on remineralization of artificial root caries. It is advantageous to find methods to enhance the remineralization effect of PA. This study evaluated the synergistic effect of PA and casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) on remineralization of artificial root caries. Method: Demineralized root fragments (n=90) were randomly divided into six groups based on treatments: (i) 6.5% PA, (ii) CPP-ACP, (iii) CPP-ACFP, (iv) CPP-ACFP + 6.5% PA, (v) 1000ppm fluoride and (vi) deionized water (control). Each specimen was immersed in the demineralizing solution for 14 h, testing solutions/pastes for 2 h and remineralizing solution for 8 h. The pH cycling was performed at 37oC for 8 days. Specimens were evaluated using transverse microradiography (lesion depth and mineral loss), a microhardness tester (Knoop hardness) and confocal laser scanning microscopy (CLSM). The lesion depth and mineral loss were analyzed using one-way ANOVA; while microhardness were analyzed with two-way ANOVA and Tukey’s test. Result: One-way ANOVA indicated that testing solutions had a significant effect on lesion depth (P<0.05) and mineral loss (P<0.05). Lesion depth was significantly lower in CPP-ACFP+PA and 1000ppm fluoride groups (P<0.05). Mineral loss was the lowest in CPP-ACFP+PA group (P<0.05). Two-way ANOVA indicated that the factors “testing solutions/pastes” and “lesion depth” had a significant effect on Knoop hardness (P<0.05), with interaction between the two factors (P<0.05). Artificial caries lesions treated with CPP-ACFP+PA showed significantly higher microhardness values at 130μm and 150 μm from the surface (P<0.05). Remineralizing bands with higher mineral density were observed in CPP-ACFP+PA group. Conclusion: The combined use of proanthocyanidin and casein phosphopeptide amorphous calcium fluoride phosphate has a synergistic effect on root caries remineralization by enhancing mineral gain and increasing hardness of the artificial root caries.-
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925-
dc.relation.ispartofJournal of Dental Researchen_US
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc..-
dc.subjectCaries-
dc.subjectProanthocyanidin-
dc.subjectRemineralization and Root-
dc.titleSynergistic effect of proanthocyanidin and CPP-ACFP on root caries remineralisationen_US
dc.typeConference_Paperen_US
dc.identifier.emailYiu, CKY: ckyyiu@hkucc.hku.hken_US
dc.identifier.emailBurrow, MF: mfburr58@hku.hken_US
dc.identifier.authorityYiu, CKY=rp00018en_US
dc.identifier.authorityBurrow, MF=rp01306en_US
dc.identifier.hkuros216888en_US
dc.identifier.volume92-
dc.identifier.issueSpecial Issue A-
dc.publisher.placeUnited States-

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