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Article: Sterilization on dextran-coated iron oxide nanoparticles: Effects of autoclaving, filtration, UV irradiation, and ethanol treatment

TitleSterilization on dextran-coated iron oxide nanoparticles: Effects of autoclaving, filtration, UV irradiation, and ethanol treatment
Authors
KeywordsAutoclave
Dextran coated magnetic nanoparticle
Filtration; Sterilization
UV irradiation
Issue Date2013
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/mee
Citation
Microelectronic Engineering, 2013, v. 111, p. 310-313 How to Cite?
AbstractDextran-coated magnetic iron oxide nanoparticles (DMNPs) have attracted significant attention for their many applications in biomedical area such as diagnostic magnetic resonance imaging (MRI), and gene therapy. For biomedical applications, nanoparticles must be sterile, and several terminal sterilization methods can be used. However, very little is known regarding the effect of sterilization methods on the properties of DMNPs. It is crucial to find out whether the DMNPs are affected by the sterilization process. This paper reported the influences on the physicochemical properties of DMNPs from four different methods: autoclaving, sterile filtration, UV irradiation and chemical sterilization with ethanol. In addition, cell viability was also studied. Our results indicate that filter sterilization changes the iron oxide/dextran ratio in DMNPs sample significantly. Besides, the autoclaving and ethanol treatment affected the polydispersity index of DMNPs sample. Thus, caution must be taken when choosing an appropriate method to perform sterilization for DMNPs. © 2013 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/185715
ISSN
2015 Impact Factor: 1.277
2015 SCImago Journal Rankings: 0.551
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Len_US
dc.contributor.authorMak, KYen_US
dc.contributor.authorShi, Jen_US
dc.contributor.authorLeung, CHen_US
dc.contributor.authorWong, CMen_US
dc.contributor.authorLeung, CWen_US
dc.contributor.authorMak, CSKen_US
dc.contributor.authorChan, KYen_US
dc.contributor.authorChan, NMMen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorPong, PWTen_US
dc.date.accessioned2013-08-20T11:37:39Z-
dc.date.available2013-08-20T11:37:39Z-
dc.date.issued2013en_US
dc.identifier.citationMicroelectronic Engineering, 2013, v. 111, p. 310-313en_US
dc.identifier.issn0167-9317-
dc.identifier.urihttp://hdl.handle.net/10722/185715-
dc.description.abstractDextran-coated magnetic iron oxide nanoparticles (DMNPs) have attracted significant attention for their many applications in biomedical area such as diagnostic magnetic resonance imaging (MRI), and gene therapy. For biomedical applications, nanoparticles must be sterile, and several terminal sterilization methods can be used. However, very little is known regarding the effect of sterilization methods on the properties of DMNPs. It is crucial to find out whether the DMNPs are affected by the sterilization process. This paper reported the influences on the physicochemical properties of DMNPs from four different methods: autoclaving, sterile filtration, UV irradiation and chemical sterilization with ethanol. In addition, cell viability was also studied. Our results indicate that filter sterilization changes the iron oxide/dextran ratio in DMNPs sample significantly. Besides, the autoclaving and ethanol treatment affected the polydispersity index of DMNPs sample. Thus, caution must be taken when choosing an appropriate method to perform sterilization for DMNPs. © 2013 Elsevier B.V. All rights reserved.-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/mee-
dc.relation.ispartofMicroelectronic Engineeringen_US
dc.subjectAutoclave-
dc.subjectDextran coated magnetic nanoparticle-
dc.subjectFiltration; Sterilization-
dc.subjectUV irradiation-
dc.titleSterilization on dextran-coated iron oxide nanoparticles: Effects of autoclaving, filtration, UV irradiation, and ethanol treatmenten_US
dc.typeArticleen_US
dc.identifier.emailLeung, CH: chleung@eee.hku.hken_US
dc.identifier.emailWong, CM: jackwong@pathology.hku.hken_US
dc.identifier.emailMak, CSK: cskm@hkucc.hku.hken_US
dc.identifier.emailChan, KY: hrsccky@hku.hken_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.emailPong, PWT: ppong@eee.hku.hken_US
dc.identifier.authorityLeung, CH=rp00146en_US
dc.identifier.authorityWong, CM=rp00231en_US
dc.identifier.authorityMak, CSK=rp00761en_US
dc.identifier.authorityChan, KY=rp00662en_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.identifier.authorityPong, PWT=rp00217en_US
dc.identifier.doi10.1016/j.mee.2013.02.021-
dc.identifier.scopuseid_2-s2.0-84885184897-
dc.identifier.hkuros219716en_US
dc.identifier.volume111en_US
dc.identifier.spage310en_US
dc.identifier.epage313en_US
dc.identifier.isiWOS:000322751300062-
dc.publisher.placeNetherlands-

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