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- Publisher Website: 10.1039/c2ob26518d
- Scopus: eid_2-s2.0-84868649502
- PMID: 22964756
- WOS: WOS:000310809800009
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Article: Diastereoselective ruthenium porphyrin-catalyzed tandem nitrone formation/1,3-dipolar cycloaddition for isoxazolidines. Synthesis, in silico docking study and in vitro biological activities
Title | Diastereoselective ruthenium porphyrin-catalyzed tandem nitrone formation/1,3-dipolar cycloaddition for isoxazolidines. Synthesis, in silico docking study and in vitro biological activities |
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Authors | |
Issue Date | 2012 |
Publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/obc |
Citation | Organic & Biomolecular Chemistry, 2012, v. 10 n. 46, p. 9165-9174 How to Cite? |
Abstract | Ruthenium porphyrin catalyzes tandem nitrone formation/1,3-dipolar cycloaddition of diazo compounds, nitrosoarenes and alkenes to form isoxazolidines in good to high yields and with excellent regio-, chemo- and diastereo-selectivities. A broad substrate scope of alkenes is applicable to this protocol and various functional groups are compatible with the reaction conditions. In silico analysis and in vitro biological experiments revealed that some of the new isoxazolidines synthesized in this work could act as leukotriene A4 hydrolase inhibitors. |
Persistent Identifier | http://hdl.handle.net/10722/185654 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.607 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Reddy, A.R. | en_US |
dc.contributor.author | Guo, Z | en_US |
dc.contributor.author | Siu, AFM | en_US |
dc.contributor.author | Lok, CN | en_US |
dc.contributor.author | Liu, F | en_US |
dc.contributor.author | Yeung, K.C. | en_US |
dc.contributor.author | Zhou, CY | en_US |
dc.contributor.author | Che, CM | en_US |
dc.date.accessioned | 2013-08-20T11:37:03Z | - |
dc.date.available | 2013-08-20T11:37:03Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Organic & Biomolecular Chemistry, 2012, v. 10 n. 46, p. 9165-9174 | en_US |
dc.identifier.issn | 1477-0520 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/185654 | - |
dc.description.abstract | Ruthenium porphyrin catalyzes tandem nitrone formation/1,3-dipolar cycloaddition of diazo compounds, nitrosoarenes and alkenes to form isoxazolidines in good to high yields and with excellent regio-, chemo- and diastereo-selectivities. A broad substrate scope of alkenes is applicable to this protocol and various functional groups are compatible with the reaction conditions. In silico analysis and in vitro biological experiments revealed that some of the new isoxazolidines synthesized in this work could act as leukotriene A4 hydrolase inhibitors. | en_US |
dc.language | eng | en_US |
dc.publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/obc | en_US |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en_US |
dc.subject.mesh | Alkenes - chemistry | en_US |
dc.subject.mesh | Azo Compounds - chemistry | en_US |
dc.subject.mesh | Enzyme Inhibitors - chemical synthesis | en_US |
dc.subject.mesh | Isoxazoles - chemical synthesis | en_US |
dc.subject.mesh | Ruthenium - chemistry | en_US |
dc.title | Diastereoselective ruthenium porphyrin-catalyzed tandem nitrone formation/1,3-dipolar cycloaddition for isoxazolidines. Synthesis, in silico docking study and in vitro biological activities | en_US |
dc.type | Article | en_US |
dc.identifier.email | Guo, Z: hkuzguo@hku.hk | en_US |
dc.identifier.email | Siu, AFM: fmsiu@hku.hk | en_US |
dc.identifier.email | Lok, CN: cnlok@hku.hk | en_US |
dc.identifier.email | Liu, F: chlfl@hku.hk | en_US |
dc.identifier.email | Zhou, CY: cyzhou@hku.hk | en_US |
dc.identifier.email | Che, CM: cmche@hku.hk | en_US |
dc.identifier.authority | Siu, AFM=rp00776 | en_US |
dc.identifier.authority | Lok, CN=rp00752 | en_US |
dc.identifier.authority | Zhou, CY=rp00843 | en_US |
dc.identifier.authority | Che, CM=rp00670 | en_US |
dc.identifier.doi | 10.1039/c2ob26518d | en_US |
dc.identifier.pmid | 22964756 | en_US |
dc.identifier.scopus | eid_2-s2.0-84868649502 | - |
dc.identifier.hkuros | 218721 | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 46 | en_US |
dc.identifier.spage | 9165 | en_US |
dc.identifier.epage | 9174 | en_US |
dc.identifier.isi | WOS:000310809800009 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.issnl | 1477-0520 | - |