File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Diastereoselective ruthenium porphyrin-catalyzed tandem nitrone formation/1,3-dipolar cycloaddition for isoxazolidines. Synthesis, in silico docking study and in vitro biological activities

TitleDiastereoselective ruthenium porphyrin-catalyzed tandem nitrone formation/1,3-dipolar cycloaddition for isoxazolidines. Synthesis, in silico docking study and in vitro biological activities
Authors
Issue Date2012
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/obc
Citation
Organic & Biomolecular Chemistry, 2012, v. 10 n. 46, p. 9165-9174 How to Cite?
AbstractRuthenium porphyrin catalyzes tandem nitrone formation/1,3-dipolar cycloaddition of diazo compounds, nitrosoarenes and alkenes to form isoxazolidines in good to high yields and with excellent regio-, chemo- and diastereo-selectivities. A broad substrate scope of alkenes is applicable to this protocol and various functional groups are compatible with the reaction conditions. In silico analysis and in vitro biological experiments revealed that some of the new isoxazolidines synthesized in this work could act as leukotriene A4 hydrolase inhibitors.
Persistent Identifierhttp://hdl.handle.net/10722/185654
ISSN
2015 Impact Factor: 3.559
2015 SCImago Journal Rankings: 1.464
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorReddy, A.R.en_US
dc.contributor.authorGuo, Zen_US
dc.contributor.authorSiu, AFMen_US
dc.contributor.authorLok, CNen_US
dc.contributor.authorLiu, Fen_US
dc.contributor.authorYeung, K.C.en_US
dc.contributor.authorZhou, CYen_US
dc.contributor.authorChe, CMen_US
dc.date.accessioned2013-08-20T11:37:03Z-
dc.date.available2013-08-20T11:37:03Z-
dc.date.issued2012en_US
dc.identifier.citationOrganic & Biomolecular Chemistry, 2012, v. 10 n. 46, p. 9165-9174en_US
dc.identifier.issn1477-0520en_US
dc.identifier.urihttp://hdl.handle.net/10722/185654-
dc.description.abstractRuthenium porphyrin catalyzes tandem nitrone formation/1,3-dipolar cycloaddition of diazo compounds, nitrosoarenes and alkenes to form isoxazolidines in good to high yields and with excellent regio-, chemo- and diastereo-selectivities. A broad substrate scope of alkenes is applicable to this protocol and various functional groups are compatible with the reaction conditions. In silico analysis and in vitro biological experiments revealed that some of the new isoxazolidines synthesized in this work could act as leukotriene A4 hydrolase inhibitors.en_US
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/obcen_US
dc.relation.ispartofOrganic & Biomolecular Chemistryen_US
dc.subject.meshAlkenes - chemistryen_US
dc.subject.meshAzo Compounds - chemistryen_US
dc.subject.meshEnzyme Inhibitors - chemical synthesisen_US
dc.subject.meshIsoxazoles - chemical synthesisen_US
dc.subject.meshRuthenium - chemistryen_US
dc.titleDiastereoselective ruthenium porphyrin-catalyzed tandem nitrone formation/1,3-dipolar cycloaddition for isoxazolidines. Synthesis, in silico docking study and in vitro biological activitiesen_US
dc.typeArticleen_US
dc.identifier.emailGuo, Z: hkuzguo@hku.hken_US
dc.identifier.emailSiu, AFM: fmsiu@hku.hken_US
dc.identifier.emailLok, CN: cnlok@hku.hken_US
dc.identifier.emailLiu, F: chlfl@hku.hken_US
dc.identifier.emailZhou, CY: cyzhou@hku.hken_US
dc.identifier.emailChe, CM: cmche@hku.hken_US
dc.identifier.authoritySiu, AFM=rp00776en_US
dc.identifier.authorityLok, CN=rp00752en_US
dc.identifier.authorityZhou, CY=rp00843en_US
dc.identifier.authorityChe, CM=rp00670en_US
dc.identifier.doi10.1039/c2ob26518den_US
dc.identifier.pmid22964756en_US
dc.identifier.hkuros218721en_US
dc.identifier.volume10en_US
dc.identifier.issue46en_US
dc.identifier.spage9165en_US
dc.identifier.epage9174en_US
dc.identifier.isiWOS:000310809800009-
dc.publisher.placeUnited Kingdomen_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats