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Article: The effects of microenvironment in mesenchymal stem cell-based regeneration of intervertebral disc

TitleThe effects of microenvironment in mesenchymal stem cell-based regeneration of intervertebral disc
Authors
KeywordsDegeneration
Intervertebral Disc
Mesenchymal Stem Cell
Microenvironment
Regeneration
Issue Date2013
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/spinee
Citation
Spine Journal, 2013, v. 13 n. 3, p. 352-362 How to Cite?
AbstractBackground context: Recent studies have demonstrated new therapeutic strategy using transplantation of mesenchymal stem cells (MSCs), especially bone marrow-derived MSCs (BM-MSCs), to preserve intervertebral disc (IVD) structure and functions. It is important to understand whether and how the MSCs survive and thrive in the hostile microenvironment of the degenerated IVD. Therefore, this review majorly examines how resident disc cells, hypoxia, low nutrition, acidic pH, mechanical loading, endogenous proteinases, and cytokines regulate the behavior of the exogenous MSCs. Purpose: To review and summarize the effect of the microenvironment in biological characteristics of BM-MSCs for IVD regeneration; the presence of endogenous stem cells and the state of the art in the use of BM-MSCs to regenerate the IVD in vivo were also discussed. Study design: Literature review. Methods: MEDLINE electronic database was used to search for articles concerning stem/progenitor cell isolation from the IVD, regulation of the components of microenvironment for MSCs, and MSC-based therapy for IVD degeneration. The search was limited to English language. Results: Stem cells are probably resident in the disc, but exogenous stem cells, especially BM-MSCs, are currently the most popular graft cells for IVD regeneration. The endogenous disc cells and the biochemical and biophysical components in the degenerating disc present a complicated microenvironment to regulate the transplanted BM-MSCs. Although MSCs regenerate the mildly degenerative disc effectively in the experimental and clinical trials, many underlying questions are in need of further investigation. Conclusions: There has been a dramatic improvement in the understanding of potential MSC-based therapy for IVD regeneration. The use of MSCs for IVD degeneration is still at the stage of preclinical and Phase 1 studies. The effects of the disc microenvironment in MSCs survival and function should be closely studied for transferring MSC transplantation from bench to bedside successfully.© 2013 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/185474
ISSN
2015 Impact Factor: 2.66
2015 SCImago Journal Rankings: 1.153
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, YCen_US
dc.contributor.authorLeung, VYLen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorLuk, KDKen_US
dc.date.accessioned2013-07-30T07:35:29Z-
dc.date.available2013-07-30T07:35:29Z-
dc.date.issued2013en_US
dc.identifier.citationSpine Journal, 2013, v. 13 n. 3, p. 352-362en_US
dc.identifier.issn1529-9430en_US
dc.identifier.urihttp://hdl.handle.net/10722/185474-
dc.description.abstractBackground context: Recent studies have demonstrated new therapeutic strategy using transplantation of mesenchymal stem cells (MSCs), especially bone marrow-derived MSCs (BM-MSCs), to preserve intervertebral disc (IVD) structure and functions. It is important to understand whether and how the MSCs survive and thrive in the hostile microenvironment of the degenerated IVD. Therefore, this review majorly examines how resident disc cells, hypoxia, low nutrition, acidic pH, mechanical loading, endogenous proteinases, and cytokines regulate the behavior of the exogenous MSCs. Purpose: To review and summarize the effect of the microenvironment in biological characteristics of BM-MSCs for IVD regeneration; the presence of endogenous stem cells and the state of the art in the use of BM-MSCs to regenerate the IVD in vivo were also discussed. Study design: Literature review. Methods: MEDLINE electronic database was used to search for articles concerning stem/progenitor cell isolation from the IVD, regulation of the components of microenvironment for MSCs, and MSC-based therapy for IVD degeneration. The search was limited to English language. Results: Stem cells are probably resident in the disc, but exogenous stem cells, especially BM-MSCs, are currently the most popular graft cells for IVD regeneration. The endogenous disc cells and the biochemical and biophysical components in the degenerating disc present a complicated microenvironment to regulate the transplanted BM-MSCs. Although MSCs regenerate the mildly degenerative disc effectively in the experimental and clinical trials, many underlying questions are in need of further investigation. Conclusions: There has been a dramatic improvement in the understanding of potential MSC-based therapy for IVD regeneration. The use of MSCs for IVD degeneration is still at the stage of preclinical and Phase 1 studies. The effects of the disc microenvironment in MSCs survival and function should be closely studied for transferring MSC transplantation from bench to bedside successfully.© 2013 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/spineeen_US
dc.relation.ispartofSpine Journalen_US
dc.subjectDegenerationen_US
dc.subjectIntervertebral Discen_US
dc.subjectMesenchymal Stem Cellen_US
dc.subjectMicroenvironmenten_US
dc.subjectRegenerationen_US
dc.titleThe effects of microenvironment in mesenchymal stem cell-based regeneration of intervertebral discen_US
dc.typeArticleen_US
dc.identifier.emailLeung, VYL: vicleung@hku.hken_US
dc.identifier.emailLu, WW: wwlu@hku.hken_US
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_US
dc.identifier.authorityLeung, VYL=rp01764en_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.spinee.2012.12.005en_US
dc.identifier.pmid23340343-
dc.identifier.scopuseid_2-s2.0-84875493714en_US
dc.identifier.hkuros223393-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84875493714&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue3en_US
dc.identifier.spage352en_US
dc.identifier.epage362en_US
dc.identifier.isiWOS:000317270400017-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridHuang, YC=55555066400en_US
dc.identifier.scopusauthoridLeung, VYL=55555155300en_US
dc.identifier.scopusauthoridLu, WW=55484358100en_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US

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