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Conference Paper: In vivo stimulation of bone formation by biodegradable polymer deposited magnesium bone bullet

TitleIn vivo stimulation of bone formation by biodegradable polymer deposited magnesium bone bullet
Authors
Issue Date2013
PublisherOrthopaedic Research Society (ORS)
Citation
The 2013 Annual Meeting of the Orthopaedic Research Society (ORS), San Antonio, TX., 26-29 January 2013. How to Cite?
AbstractINTRODUCTION: Bone morphogenetic proteins and insulin-like growth factor can theoretically apply to stimulate bone formation. However, uncontrolled release rate and systemic effects outside of the musculoskeletal tissues hamper their use clinically. Hence, we propose a simple approach to stimulate bone formation by using our newly developed magnesium bullet. Magnesium is chosen as one of the major components for the bullet, since the presence of Mg ions is able to stimulate bone growth and bone healing thru the enhancement of osteoblast and osteoclast activities. However, rapid degradation of magnesium and release of hydrogen gas impede its medical applications. Therefore, we have successfully developed a biopolymer coating named polycaprolactone (PCL) to control the degradation rate of Mg bullet. This paper reports the in vitro and in vivo properties as well as bone forming ability of this novel de…
DescriptionTheme: Bridging Innovation
Poster Session 2 (PS2) Biomaterial: no. 1227
Persistent Identifierhttp://hdl.handle.net/10722/185033

 

DC FieldValueLanguage
dc.contributor.authorYeung, Ken_US
dc.contributor.authorWong, Ken_US
dc.contributor.authorChu, PKen_US
dc.contributor.authorCheung, KMCen_US
dc.contributor.authorLuk, KDKen_US
dc.date.accessioned2013-07-15T10:25:25Z-
dc.date.available2013-07-15T10:25:25Z-
dc.date.issued2013en_US
dc.identifier.citationThe 2013 Annual Meeting of the Orthopaedic Research Society (ORS), San Antonio, TX., 26-29 January 2013.en_US
dc.identifier.urihttp://hdl.handle.net/10722/185033-
dc.descriptionTheme: Bridging Innovation-
dc.descriptionPoster Session 2 (PS2) Biomaterial: no. 1227-
dc.description.abstractINTRODUCTION: Bone morphogenetic proteins and insulin-like growth factor can theoretically apply to stimulate bone formation. However, uncontrolled release rate and systemic effects outside of the musculoskeletal tissues hamper their use clinically. Hence, we propose a simple approach to stimulate bone formation by using our newly developed magnesium bullet. Magnesium is chosen as one of the major components for the bullet, since the presence of Mg ions is able to stimulate bone growth and bone healing thru the enhancement of osteoblast and osteoclast activities. However, rapid degradation of magnesium and release of hydrogen gas impede its medical applications. Therefore, we have successfully developed a biopolymer coating named polycaprolactone (PCL) to control the degradation rate of Mg bullet. This paper reports the in vitro and in vivo properties as well as bone forming ability of this novel de…-
dc.languageengen_US
dc.publisherOrthopaedic Research Society (ORS)-
dc.relation.ispartof2013 ORS Annual Meetingen_US
dc.titleIn vivo stimulation of bone formation by biodegradable polymer deposited magnesium bone bulleten_US
dc.typeConference_Paperen_US
dc.identifier.emailYeung, K: wkkyeung@hku.hken_US
dc.identifier.emailWong, K: khmwong@hku.hken_US
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_US
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_US
dc.identifier.authorityYeung, K=rp00309en_US
dc.identifier.authorityCheung, KMC=rp00387en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros215904en_US
dc.publisher.placeUnited States-

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