File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis

TitleClinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis
Authors
Issue Date2013
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jcm.asm.org/
Citation
Journal of Clinical Microbiology, 2013, v. 51 n. 1, p. 260-267 How to Cite?
AbstractWe characterized 12 Exophiala strains isolated from patients over a 15-year period to the species level using phenotypic tests and internal transcribed spacer (ITS) and Rpb1 sequencing and described the clinical spectrum of the 12 patients. Eight patients had nail or skin infections, two had invasive infections, and two had colonization of the gastrointestinal tract. ITS and Rpb1 sequencing showed that 11 of the 12 strains were known Exophiala species ( E. oligosperma [n = 3], E. jeanselmei [n = 2], E. lecanii-corni [n = 2], E. bergeri [n = 1], E. cancerae [n = 1], E. dermatitidis [n = 1], and E. xenobiotica [n = 1]), which included the first reported cases of onychomycosis caused by E. bergeri and E. oligosperma. The 12th strain (HKU32T), isolated from the nail clipping of the right big toe of a 68-year-old female patient with onychomycosis, possessed unique morphological characteristics distinct from other Exophiala species. It grew very slowly and had a velvety colony texture after 28 days, short conidiophores of the same olivaceous color as the supporting hyphae, numerous spores, and no chlamydospore-like cells. ITS, Rpb1, β-tubulin, and β-actin gene sequencing unambiguously showed that HKU32T was clustered with but formed branches distinct from other Exophiala species in phylogenetic trees. We propose the new species Exophiala hongkongensis to describe this novel fungus.
Persistent Identifierhttp://hdl.handle.net/10722/184596
ISSN
2017 Impact Factor: 4.054
2015 SCImago Journal Rankings: 2.151
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWoo, PCY-
dc.contributor.authorNgan, AHY-
dc.contributor.authorTsang, CC-
dc.contributor.authorLing, IWH-
dc.contributor.authorChan, JFW-
dc.contributor.authorLeung, SY-
dc.contributor.authorYuen, KY-
dc.contributor.authorLau, SKP-
dc.date.accessioned2013-07-15T09:57:32Z-
dc.date.available2013-07-15T09:57:32Z-
dc.date.issued2013-
dc.identifier.citationJournal of Clinical Microbiology, 2013, v. 51 n. 1, p. 260-267-
dc.identifier.issn0095-1137-
dc.identifier.urihttp://hdl.handle.net/10722/184596-
dc.description.abstractWe characterized 12 Exophiala strains isolated from patients over a 15-year period to the species level using phenotypic tests and internal transcribed spacer (ITS) and Rpb1 sequencing and described the clinical spectrum of the 12 patients. Eight patients had nail or skin infections, two had invasive infections, and two had colonization of the gastrointestinal tract. ITS and Rpb1 sequencing showed that 11 of the 12 strains were known Exophiala species ( E. oligosperma [n = 3], E. jeanselmei [n = 2], E. lecanii-corni [n = 2], E. bergeri [n = 1], E. cancerae [n = 1], E. dermatitidis [n = 1], and E. xenobiotica [n = 1]), which included the first reported cases of onychomycosis caused by E. bergeri and E. oligosperma. The 12th strain (HKU32T), isolated from the nail clipping of the right big toe of a 68-year-old female patient with onychomycosis, possessed unique morphological characteristics distinct from other Exophiala species. It grew very slowly and had a velvety colony texture after 28 days, short conidiophores of the same olivaceous color as the supporting hyphae, numerous spores, and no chlamydospore-like cells. ITS, Rpb1, β-tubulin, and β-actin gene sequencing unambiguously showed that HKU32T was clustered with but formed branches distinct from other Exophiala species in phylogenetic trees. We propose the new species Exophiala hongkongensis to describe this novel fungus.-
dc.languageeng-
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jcm.asm.org/-
dc.relation.ispartofJournal of Clinical Microbiology-
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleClinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis-
dc.typeArticle-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.authorityWoo, PCY=rp00430-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityLau, SKP=rp00486-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1128/JCM.02336-12-
dc.identifier.pmid23152554-
dc.identifier.pmcidPMC3536265-
dc.identifier.scopuseid_2-s2.0-84871698281-
dc.identifier.hkuros216351-
dc.identifier.volume51-
dc.identifier.issue1-
dc.identifier.spage260-
dc.identifier.epage267-
dc.identifier.isiWOS:000314105100043-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats