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Article: Magnetic, fluorescent, and thermo-responsive Fe3O4/rare earth incorporated poly (St-NIPAM) core-shell colloidal nanoparticles in multimodal optical/magnetic resonance imaging probes

TitleMagnetic, fluorescent, and thermo-responsive Fe3O4/rare earth incorporated poly (St-NIPAM) core-shell colloidal nanoparticles in multimodal optical/magnetic resonance imaging probes
Authors
Issue Date2013
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2013, v. 34 n. 9, p. 2296-2306 How to Cite?
AbstractMultifunctional colloidal nanoparticles which exhibit fluorescence, superparamagnetism, and thermosensitivity are produced by two step seed emulsifier-free emulsion polymerization in the presence of oleic acid (OA) and sodium undecylenate (NaUA) modified Fe(3)O(4) nanoparticles. In the first step, St and NIPAM polymerize the NaUA on the surface of Fe(3)O(4) nanoparticles to form Fe(3)O(4)/poly(St-NIPAM) nanoparticles which act as seeds for the polymerization of Eu(AA)(3)Phen with the remaining St and NIPAM in the second step to form an outer fluorescent layer. The core-shell composite nanoparticles show reversible dimensional changes in response to external temperature stimuli. Fluorescence spectra acquired from the composites exhibit characteristic emission peaks of Eu(3+) at 594 and 619 nm and vivid red luminescence can be observed by 2-photon confocal scanning laser microscopy (CLSM). In vitro cytotoxicity tests based on the MTT assay demonstrate good cytocompatibility and the composites also possess paramagnetic properties with a maximum saturation magnetization of 6.45 emu/g and high transverse relaxivity rates (r(2)) of 411.78 mM(-1) s(-1). In vivo magnetic resonance imaging (MRI) studies show significant liver and spleen contrast with relative signal intensity reduction of about 86% 10 min after intravenous injection of the composites. These intriguing properties suggest that these nanocarriers have large clinical potential as multimodal optical/MRI probes.
Persistent Identifierhttp://hdl.handle.net/10722/184336
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhu, H-
dc.contributor.authorTao, J-
dc.contributor.authorWang, W-
dc.contributor.authorZhou, Y-
dc.contributor.authorLi, P-
dc.contributor.authorLi, Z-
dc.contributor.authorYan, K-
dc.contributor.authorWu, S-
dc.contributor.authorYeung, KWK-
dc.contributor.authorXu, Z-
dc.contributor.authorXu, H-
dc.contributor.authorChu, PK-
dc.date.accessioned2013-07-12T07:42:13Z-
dc.date.available2013-07-12T07:42:13Z-
dc.date.issued2013-
dc.identifier.citationBiomaterials, 2013, v. 34 n. 9, p. 2296-2306-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10722/184336-
dc.description.abstractMultifunctional colloidal nanoparticles which exhibit fluorescence, superparamagnetism, and thermosensitivity are produced by two step seed emulsifier-free emulsion polymerization in the presence of oleic acid (OA) and sodium undecylenate (NaUA) modified Fe(3)O(4) nanoparticles. In the first step, St and NIPAM polymerize the NaUA on the surface of Fe(3)O(4) nanoparticles to form Fe(3)O(4)/poly(St-NIPAM) nanoparticles which act as seeds for the polymerization of Eu(AA)(3)Phen with the remaining St and NIPAM in the second step to form an outer fluorescent layer. The core-shell composite nanoparticles show reversible dimensional changes in response to external temperature stimuli. Fluorescence spectra acquired from the composites exhibit characteristic emission peaks of Eu(3+) at 594 and 619 nm and vivid red luminescence can be observed by 2-photon confocal scanning laser microscopy (CLSM). In vitro cytotoxicity tests based on the MTT assay demonstrate good cytocompatibility and the composites also possess paramagnetic properties with a maximum saturation magnetization of 6.45 emu/g and high transverse relaxivity rates (r(2)) of 411.78 mM(-1) s(-1). In vivo magnetic resonance imaging (MRI) studies show significant liver and spleen contrast with relative signal intensity reduction of about 86% 10 min after intravenous injection of the composites. These intriguing properties suggest that these nanocarriers have large clinical potential as multimodal optical/MRI probes.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials-
dc.relation.ispartofBiomaterials-
dc.titleMagnetic, fluorescent, and thermo-responsive Fe3O4/rare earth incorporated poly (St-NIPAM) core-shell colloidal nanoparticles in multimodal optical/magnetic resonance imaging probesen_US
dc.typeArticleen_US
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.doi10.1016/j.biomaterials.2012.11.056-
dc.identifier.pmid23274069-
dc.identifier.hkuros215849-
dc.identifier.hkuros237674-
dc.identifier.volume34-
dc.identifier.issue9-
dc.identifier.spage2296-
dc.identifier.epage2306-
dc.identifier.isiWOS:000315179200015-
dc.publisher.placeNetherlands-
dc.customcontrol.immutablecsl 130712-

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