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Article: Sublingual misoprostol compared to artificial rupture of membranes plus oxytocin infusion for labour induction in nulliparous women with a favourable cervix at term

TitleSublingual misoprostol compared to artificial rupture of membranes plus oxytocin infusion for labour induction in nulliparous women with a favourable cervix at term
Authors
Issue Date2006
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
Hong Kong Medical Journal, 2006, v. 12 n. 5, p. 345-350 How to Cite?
AbstractObjectives. To compare the efficacy of labour induction using sublingual misoprostol versus combined artificial rupture of membranes and oxytocin infusion for nulliparous women with a favourable cervix at term. Design. Open randomised controlled trial. Setting. Regional hospital, Hong Kong. Patients. Fifty nulliparous women with a favourable cervix (Bishop score 6 or more) at term and indications for labour induction. Interventions. With their informed consent, 100 eligible women were to be randomised to receive either sublingual misoprostol 50 μg every 4 hours for up to five doses or oxytocin infusion after artificial rupture of membranes. Interim analysis was planned at a sample size of 50. Main outcome measures. Vaginal delivery within 24 hours of induction. Results. The study was terminated when interim analysis of the first 50 recruits showed that a significantly smaller proportion of misoprostol-treated women delivered vaginally within 24 hours of induction than in the conventional treatment group (68% vs 100%; relative risk, 0.68; 95% confidence interval, 0.51-0.91; P=0.009), although comparable numbers of women eventually delivered vaginally. The mean induction to vaginal delivery interval was 4.5 hours longer in the misoprostol group (P=0.027). After misoprostol treatment, all women went into labour. Forty percent of them delivered without oxytocin. There was no significant difference in uterine hyperstimulation rate, operative delivery rate, and neonatal outcomes. Maternal satisfaction was higher in the misoprostol group (92% vs 60%; relative risk, 1.53; 95% confidence interval, 1.09-2.16; P=0.008). Conclusions. Despite being well accepted by women, labour induction using this regimen of sublingual misoprostol is less effective in achieving vaginal delivery within 24 hours.
Persistent Identifierhttp://hdl.handle.net/10722/184208
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279
References

 

DC FieldValueLanguage
dc.contributor.authorLo, TKen_US
dc.contributor.authorLau, WLen_US
dc.contributor.authorWong, KSen_US
dc.contributor.authorTang, LCHen_US
dc.date.accessioned2013-06-25T03:01:23Z-
dc.date.available2013-06-25T03:01:23Z-
dc.date.issued2006en_US
dc.identifier.citationHong Kong Medical Journal, 2006, v. 12 n. 5, p. 345-350en_US
dc.identifier.issn1024-2708en_US
dc.identifier.urihttp://hdl.handle.net/10722/184208-
dc.description.abstractObjectives. To compare the efficacy of labour induction using sublingual misoprostol versus combined artificial rupture of membranes and oxytocin infusion for nulliparous women with a favourable cervix at term. Design. Open randomised controlled trial. Setting. Regional hospital, Hong Kong. Patients. Fifty nulliparous women with a favourable cervix (Bishop score 6 or more) at term and indications for labour induction. Interventions. With their informed consent, 100 eligible women were to be randomised to receive either sublingual misoprostol 50 μg every 4 hours for up to five doses or oxytocin infusion after artificial rupture of membranes. Interim analysis was planned at a sample size of 50. Main outcome measures. Vaginal delivery within 24 hours of induction. Results. The study was terminated when interim analysis of the first 50 recruits showed that a significantly smaller proportion of misoprostol-treated women delivered vaginally within 24 hours of induction than in the conventional treatment group (68% vs 100%; relative risk, 0.68; 95% confidence interval, 0.51-0.91; P=0.009), although comparable numbers of women eventually delivered vaginally. The mean induction to vaginal delivery interval was 4.5 hours longer in the misoprostol group (P=0.027). After misoprostol treatment, all women went into labour. Forty percent of them delivered without oxytocin. There was no significant difference in uterine hyperstimulation rate, operative delivery rate, and neonatal outcomes. Maternal satisfaction was higher in the misoprostol group (92% vs 60%; relative risk, 1.53; 95% confidence interval, 1.09-2.16; P=0.008). Conclusions. Despite being well accepted by women, labour induction using this regimen of sublingual misoprostol is less effective in achieving vaginal delivery within 24 hours.en_US
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hken_US
dc.relation.ispartofHong Kong Medical Journalen_US
dc.subject.meshAdministration, Sublingualen_US
dc.subject.meshCervix Uteri - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLabor, Induceden_US
dc.subject.meshMisoprostol - Administration & Dosageen_US
dc.subject.meshOxytocics - Administration & Dosageen_US
dc.subject.meshOxytocin - Administration & Dosageen_US
dc.subject.meshParityen_US
dc.subject.meshPregnancyen_US
dc.titleSublingual misoprostol compared to artificial rupture of membranes plus oxytocin infusion for labour induction in nulliparous women with a favourable cervix at termen_US
dc.typeArticleen_US
dc.identifier.emailTang, LCH: lchtang@hku.hken_US
dc.identifier.authorityTang, LCH=rp01756en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17028353-
dc.identifier.scopuseid_2-s2.0-33750051036en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750051036&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue5en_US
dc.identifier.spage345en_US
dc.identifier.epage350en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridLo, TK=7203076032en_US
dc.identifier.scopusauthoridLau, WL=12142218500en_US
dc.identifier.scopusauthoridWong, KS=36341790700en_US
dc.identifier.scopusauthoridTang, LCH=7402081111en_US

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