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Article: An open and randomized study comparing the efficacy of standard danazol and modified triptorelin regimens for postoperative disease management of moderate to severe endometriosis

TitleAn open and randomized study comparing the efficacy of standard danazol and modified triptorelin regimens for postoperative disease management of moderate to severe endometriosis
Authors
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
Citation
Fertility And Sterility, 2004, v. 81 n. 6, p. 1522-1527 How to Cite?
AbstractObjective To compare the efficacy of danazol and triptorelin (Decapeptyl CR, Ferring, Kiel, Germany) in the management of moderate and severe endometriosis in terms of symptom control and revised American Fertility Society (AFS) score reduction, and to evaluate the hormonal profile of patients treated with triptorelin every 6 weeks. Design Open and randomized trial. Setting Kwong Wah Hospital, a large public hospital in an urban location (Hong Kong). Patient(s) Forty patients after their first conservative operation for endometriosis, with surgical confirmation of revised AFS stage III or IV endometriosis. Intervention(s) Postoperative 6 months' therapy of danazol or triptorelin every 6 weeks, postmedical therapy second-look laparoscopy. Main outcome measure(s) Symptom control and patients' tolerance during medical therapy, posttherapy revised AFS score, hormonal profile during triptorelin therapy. Result(s) Pain control was similar between danazol and triptorelin therapy. There was less breakthrough bleeding with triptorelin. More patients failed to complete the whole course of danazol because of its side effects. The revised AFS score at second-look laparoscopy did not show a significant difference between the two medications. Adequate pituitary suppression was observed with injection of triptorelin every 6 weeks. Conclusion(s): Lengthening of triptorelin administration intervals from 4 weeks to 6 weeks is effective in maintaining a hypoestrogenic state. Patients were more compliant with triptorelin than danazol. Thus, triptorelin injection every 6 weeks is more cost-effective than conventional regimens. © 2004 by American Society for Reproductive Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/184206
ISSN
2015 Impact Factor: 4.426
2015 SCImago Journal Rankings: 2.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, AYKen_US
dc.contributor.authorTang, Len_US
dc.date.accessioned2013-06-25T03:01:22Z-
dc.date.available2013-06-25T03:01:22Z-
dc.date.issued2004en_US
dc.identifier.citationFertility And Sterility, 2004, v. 81 n. 6, p. 1522-1527en_US
dc.identifier.issn0015-0282en_US
dc.identifier.urihttp://hdl.handle.net/10722/184206-
dc.description.abstractObjective To compare the efficacy of danazol and triptorelin (Decapeptyl CR, Ferring, Kiel, Germany) in the management of moderate and severe endometriosis in terms of symptom control and revised American Fertility Society (AFS) score reduction, and to evaluate the hormonal profile of patients treated with triptorelin every 6 weeks. Design Open and randomized trial. Setting Kwong Wah Hospital, a large public hospital in an urban location (Hong Kong). Patient(s) Forty patients after their first conservative operation for endometriosis, with surgical confirmation of revised AFS stage III or IV endometriosis. Intervention(s) Postoperative 6 months' therapy of danazol or triptorelin every 6 weeks, postmedical therapy second-look laparoscopy. Main outcome measure(s) Symptom control and patients' tolerance during medical therapy, posttherapy revised AFS score, hormonal profile during triptorelin therapy. Result(s) Pain control was similar between danazol and triptorelin therapy. There was less breakthrough bleeding with triptorelin. More patients failed to complete the whole course of danazol because of its side effects. The revised AFS score at second-look laparoscopy did not show a significant difference between the two medications. Adequate pituitary suppression was observed with injection of triptorelin every 6 weeks. Conclusion(s): Lengthening of triptorelin administration intervals from 4 weeks to 6 weeks is effective in maintaining a hypoestrogenic state. Patients were more compliant with triptorelin than danazol. Thus, triptorelin injection every 6 weeks is more cost-effective than conventional regimens. © 2004 by American Society for Reproductive Medicine.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnsterten_US
dc.relation.ispartofFertility and Sterilityen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshCost-Benefit Analysisen_US
dc.subject.meshDanazol - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Costsen_US
dc.subject.meshEndometriosis - Drug Therapy - Physiopathology - Surgeryen_US
dc.subject.meshEstrogen Antagonists - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intramuscularen_US
dc.subject.meshLuteolytic Agents - Administration & Dosage - Economics - Therapeutic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPain - Physiopathologyen_US
dc.subject.meshPalliative Careen_US
dc.subject.meshPatient Complianceen_US
dc.subject.meshPatient Dropoutsen_US
dc.subject.meshPostoperative Careen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshTriptorelin Pamoate - Administration & Dosage - Economics - Therapeutic Useen_US
dc.titleAn open and randomized study comparing the efficacy of standard danazol and modified triptorelin regimens for postoperative disease management of moderate to severe endometriosisen_US
dc.typeArticleen_US
dc.identifier.emailTang, L: lchtang@hku.hken_US
dc.identifier.authorityTang, L=rp01756en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.fertnstert.2003.12.020en_US
dc.identifier.pmid15193471-
dc.identifier.scopuseid_2-s2.0-2942574729en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942574729&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume81en_US
dc.identifier.issue6en_US
dc.identifier.spage1522en_US
dc.identifier.epage1527en_US
dc.identifier.isiWOS:000222108800012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, AYK=7403147449en_US
dc.identifier.scopusauthoridTang, L=7402081111en_US

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