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Article: Effect of clomiphene citrate on human spermatozoal motility and fertilizing capacity in vitro

TitleEffect of clomiphene citrate on human spermatozoal motility and fertilizing capacity in vitro
Authors
Issue Date1985
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
Citation
Fertility And Sterility, 1985, v. 43 n. 5, p. 773-776 How to Cite?
AbstractThe effect of clomiphene citrate (CC) at various concentrations (0.005, 0.05, 0.5, 5, and 50 μg/ml) on the in vitro motility and fertilizing capacity of human spermatozoa was studied. Spermatozoa collected from 14 normal men were washed in modified Krebs-Ringer solution (Biggers, Whitten and Whittingham [BWW] medium) and incubated with CC for 5 hours, the period required for spermatozoal capacitation. The percent motilities of spermatozoa were recorded at 0 and 5 hours during incubation with CC. After incubation, the spermatozoa were washed with BWW medium to remove CC before insemination of the zona-free hamster ova. CC caused a significant dose-dependent decrease in the penetration of denuded hamster ova in comparison with the control (P<0.05). Significant depressive effect on spermatozoal motility was observed with CC at 0.05 μg/ml or higher concentrations (P<0.05). These results indicate that (1) CC decreases human spermatozoal fertilizing capacity in vitro and (2) the inhibitory effect on fertilizing capacity could be due to the sperm-immobilizing activity of CC.
Persistent Identifierhttp://hdl.handle.net/10722/184167
ISSN
2015 Impact Factor: 4.426
2015 SCImago Journal Rankings: 2.156
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, SYWen_US
dc.contributor.authorWang, CCLen_US
dc.contributor.authorTang, LCHen_US
dc.date.accessioned2013-06-25T03:00:57Z-
dc.date.available2013-06-25T03:00:57Z-
dc.date.issued1985en_US
dc.identifier.citationFertility And Sterility, 1985, v. 43 n. 5, p. 773-776en_US
dc.identifier.issn0015-0282en_US
dc.identifier.urihttp://hdl.handle.net/10722/184167-
dc.description.abstractThe effect of clomiphene citrate (CC) at various concentrations (0.005, 0.05, 0.5, 5, and 50 μg/ml) on the in vitro motility and fertilizing capacity of human spermatozoa was studied. Spermatozoa collected from 14 normal men were washed in modified Krebs-Ringer solution (Biggers, Whitten and Whittingham [BWW] medium) and incubated with CC for 5 hours, the period required for spermatozoal capacitation. The percent motilities of spermatozoa were recorded at 0 and 5 hours during incubation with CC. After incubation, the spermatozoa were washed with BWW medium to remove CC before insemination of the zona-free hamster ova. CC caused a significant dose-dependent decrease in the penetration of denuded hamster ova in comparison with the control (P<0.05). Significant depressive effect on spermatozoal motility was observed with CC at 0.05 μg/ml or higher concentrations (P<0.05). These results indicate that (1) CC decreases human spermatozoal fertilizing capacity in vitro and (2) the inhibitory effect on fertilizing capacity could be due to the sperm-immobilizing activity of CC.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnsterten_US
dc.relation.ispartofFertility and Sterilityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshClomiphene - Pharmacologyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshFemaleen_US
dc.subject.meshFertilization In Vitroen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshSperm Motility - Drug Effectsen_US
dc.titleEffect of clomiphene citrate on human spermatozoal motility and fertilizing capacity in vitroen_US
dc.typeArticleen_US
dc.identifier.emailTang, LCH: lchtang@hku.hken_US
dc.identifier.authorityTang, LCH=rp01756en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3996624-
dc.identifier.scopuseid_2-s2.0-0021846988en_US
dc.identifier.volume43en_US
dc.identifier.issue5en_US
dc.identifier.spage773en_US
dc.identifier.epage776en_US
dc.identifier.isiWOS:A1985AHF4700017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, SYW=7404255960en_US
dc.identifier.scopusauthoridWang, CCL=7501631357en_US
dc.identifier.scopusauthoridTang, LCH=7402081111en_US

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