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Article: Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation
Title | Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation |
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Authors | |
Keywords | Graves' ophthalmopathy Intensity-modulated radiation therapy Retro-orbital irradiation |
Issue Date | 2012 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.ro-journal.com |
Citation | Radiation Oncology, 2012, v. 7, article no. 199 How to Cite? |
Abstract | Background:
We would like to investigate the if IMRT produced better target coverage and dose sparing to adjacent normal structures as compared with 3-dimensional conformal radiotherapy (3DCRT) and lateral opposing fields (LOF) for patients with Graves’ ophthalmopathy treated with retro-orbital irradiation.
Methods:
Ten consecutive patients diagnosed with Graves’ ophthalmopathy were prospectively recruited into this study. An individual IMRT, 3DCRT and LOF plan was created for each patient. Conformity index (CI), homogeneity index (HI) and other dosimetric parameters of the targets and organs-at-risk (OAR) generated by IMRT were compared with the other two techniques.
Results:
Mann–Whitney U test demonstrated that CI generated by IMRT was superior to that produced by 3DCRT and LOF (p=0.005 for both respectively). Similarly HI with IMRT was proven better than 3DCRT (p=0.007) and LOF (p=0.005). IMRT gave rise to better dose sparing to some OARs including globes, lenses and optic nerves as compared with 3DCRT but not with LOF.
Conclusions:
IMRT, as compared with 3DCRT and LOF, was found to have a better target coverage, conformity and homogeneity and dose sparing to some surrounding structures, despite a slight increase but clinically negligible dose to other structures. Dosimetrically it might be a preferred treatment technique and a longer follow up is warranted to establish its role in routine clinical use. |
Persistent Identifier | http://hdl.handle.net/10722/183709 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.033 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, VHF | en_US |
dc.contributor.author | Ng, CY | en_US |
dc.contributor.author | Choi, CW | en_US |
dc.contributor.author | Luk, MY | en_US |
dc.contributor.author | Leung, TW | en_US |
dc.contributor.author | Au, GKH | en_US |
dc.contributor.author | Kwong, DLW | en_US |
dc.date.accessioned | 2013-06-18T04:09:22Z | - |
dc.date.available | 2013-06-18T04:09:22Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Radiation Oncology, 2012, v. 7, article no. 199 | en_US |
dc.identifier.issn | 1748-717X | - |
dc.identifier.uri | http://hdl.handle.net/10722/183709 | - |
dc.description.abstract | Background: We would like to investigate the if IMRT produced better target coverage and dose sparing to adjacent normal structures as compared with 3-dimensional conformal radiotherapy (3DCRT) and lateral opposing fields (LOF) for patients with Graves’ ophthalmopathy treated with retro-orbital irradiation. Methods: Ten consecutive patients diagnosed with Graves’ ophthalmopathy were prospectively recruited into this study. An individual IMRT, 3DCRT and LOF plan was created for each patient. Conformity index (CI), homogeneity index (HI) and other dosimetric parameters of the targets and organs-at-risk (OAR) generated by IMRT were compared with the other two techniques. Results: Mann–Whitney U test demonstrated that CI generated by IMRT was superior to that produced by 3DCRT and LOF (p=0.005 for both respectively). Similarly HI with IMRT was proven better than 3DCRT (p=0.007) and LOF (p=0.005). IMRT gave rise to better dose sparing to some OARs including globes, lenses and optic nerves as compared with 3DCRT but not with LOF. Conclusions: IMRT, as compared with 3DCRT and LOF, was found to have a better target coverage, conformity and homogeneity and dose sparing to some surrounding structures, despite a slight increase but clinically negligible dose to other structures. Dosimetrically it might be a preferred treatment technique and a longer follow up is warranted to establish its role in routine clinical use. | - |
dc.language | eng | en_US |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.ro-journal.com | - |
dc.relation.ispartof | Radiation Oncology | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Graves' ophthalmopathy | - |
dc.subject | Intensity-modulated radiation therapy | - |
dc.subject | Retro-orbital irradiation | - |
dc.title | Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, VHF: vhflee@hku.hk | en_US |
dc.identifier.email | Ng, CY: ngchoryi@hku.hk | en_US |
dc.identifier.email | Choi, CW: hcchoi@hku.hk | en_US |
dc.identifier.email | Luk, MY: myluk@hkucc.hku.hk | en_US |
dc.identifier.email | Leung, TW: ltw920@hkucc.hku.hk | en_US |
dc.identifier.email | Au, GKH: hkugkhau@hku.hk | en_US |
dc.identifier.email | Kwong, DLW: dlwkwong@hku.hk | en_US |
dc.identifier.authority | Lee, VHF=rp00264 | en_US |
dc.identifier.authority | Kwong, DLW=rp00414 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/1748-717X-7-199 | - |
dc.identifier.pmid | 23181900 | - |
dc.identifier.pmcid | PMC3573990 | - |
dc.identifier.scopus | eid_2-s2.0-84869875624 | - |
dc.identifier.hkuros | 214647 | en_US |
dc.identifier.hkuros | 239721 | - |
dc.identifier.volume | 7 | en_US |
dc.identifier.spage | article no. 199 | - |
dc.identifier.epage | article no. 199 | - |
dc.identifier.isi | WOS:000315406700001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1748-717X | - |