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Article: Generation of integration-free neural progenitor cells from cells in human urine

TitleGeneration of integration-free neural progenitor cells from cells in human urine
Authors
Issue Date2013
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nmeth
Citation
Nature Methods, 2013, v. 10 n. 1, p. 84-89 How to Cite?
AbstractHuman neural stem cells hold great promise for research and therapy in neural disease. We describe the generation of integration-free and expandable human neural progenitor cells (NPCs). We combined an episomal system to deliver reprogramming factors with a chemically defined culture medium to reprogram epithelial-like cells from human urine into NPCs (hUiNPCs). These transgene-free hUiNPCs can self-renew and can differentiate into multiple functional neuronal subtypes and glial cells in vitro. Although functional in vivo analysis is still needed, we report that the cells survive and differentiate upon transplant into newborn rat brain.
Persistent Identifierhttp://hdl.handle.net/10722/183681
ISSN
2015 Impact Factor: 25.328
2015 SCImago Journal Rankings: 21.715
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Len_US
dc.contributor.authorWang, Len_US
dc.contributor.authorHuang, Wen_US
dc.contributor.authorSu, Hen_US
dc.contributor.authorXue, Yen_US
dc.contributor.authorSu, Zen_US
dc.contributor.authorLiao, Ben_US
dc.contributor.authorWang, Hen_US
dc.contributor.authorBao, Xen_US
dc.contributor.authorQin, Den_US
dc.contributor.authorHe, Jen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2013-06-18T04:07:19Z-
dc.date.available2013-06-18T04:07:19Z-
dc.date.issued2013en_US
dc.identifier.citationNature Methods, 2013, v. 10 n. 1, p. 84-89en_US
dc.identifier.issn1548-7091-
dc.identifier.urihttp://hdl.handle.net/10722/183681-
dc.description.abstractHuman neural stem cells hold great promise for research and therapy in neural disease. We describe the generation of integration-free and expandable human neural progenitor cells (NPCs). We combined an episomal system to deliver reprogramming factors with a chemically defined culture medium to reprogram epithelial-like cells from human urine into NPCs (hUiNPCs). These transgene-free hUiNPCs can self-renew and can differentiate into multiple functional neuronal subtypes and glial cells in vitro. Although functional in vivo analysis is still needed, we report that the cells survive and differentiate upon transplant into newborn rat brain.-
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nmeth-
dc.relation.ispartofNature Methodsen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleGeneration of integration-free neural progenitor cells from cells in human urineen_US
dc.typeArticleen_US
dc.identifier.emailSu, H: hxsu@hku.hken_US
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturepostprint-
dc.identifier.doi10.1038/nmeth.2283-
dc.identifier.pmid23223155-
dc.identifier.hkuros214424en_US
dc.identifier.volume10en_US
dc.identifier.issue1en_US
dc.identifier.spage84en_US
dc.identifier.epage89en_US
dc.identifier.isiWOS:000312810100043-
dc.identifier.f1000717968104-

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