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Article: Elevated blood pressure is associated with rarefaction of the retinal vasculature in children

TitleElevated blood pressure is associated with rarefaction of the retinal vasculature in children
Authors
Issue Date2012
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2012, v. 53 n. 1, p. 470-474 How to Cite?
AbstractPURPOSE. Retinal vascular fractal dimension (D f) is a measure of the geometric complexity of the retinal microvasculature, and has been associated with diabetic retinopathy. In this study, the authors examined the relationship between blood pressure and retinal D f in children. METHODS. Among 1174 children aged 10 to 14 years who participated in the Singapore Cohort Study of Risk Factors for Myopia, retinal D f was measured from digital fundus images using a computer-based program following a standardized protocol. Blood pressure was calculated from the average of three separate measurements in a seated position. RESULTS. The analysis shows that retinal D f was normally distributed, with a mean of 1.4619 (SD, 0.0144). After adjusting for age, sex, height, and retinal arteriolar and venular caliber, smaller retinal D f was correlated with elevated mean arterial blood pressure (P = 0.02), diastolic blood pressure (P = 0.02), and possibly systolic blood pressure (P = 0.06). CONCLUSIONS. Higher blood pressure in children is associated with smaller retinal D f, reflecting rarefaction of the retinal microvasculature. Retinal fractal analysis detects early subtle microvascular effects of elevated blood pressure, and may further the understanding of the genesis of ocular and systemic vascular complications of hypertension. © 2012 The Association for Research in Vision and Ophthalmology, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/183617
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKurniawan, EDen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorCheung, CYen_US
dc.contributor.authorTay, WTen_US
dc.contributor.authorSaw, SMen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:26Z-
dc.date.available2013-05-28T06:15:26Z-
dc.date.issued2012en_US
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2012, v. 53 n. 1, p. 470-474en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/183617-
dc.description.abstractPURPOSE. Retinal vascular fractal dimension (D f) is a measure of the geometric complexity of the retinal microvasculature, and has been associated with diabetic retinopathy. In this study, the authors examined the relationship between blood pressure and retinal D f in children. METHODS. Among 1174 children aged 10 to 14 years who participated in the Singapore Cohort Study of Risk Factors for Myopia, retinal D f was measured from digital fundus images using a computer-based program following a standardized protocol. Blood pressure was calculated from the average of three separate measurements in a seated position. RESULTS. The analysis shows that retinal D f was normally distributed, with a mean of 1.4619 (SD, 0.0144). After adjusting for age, sex, height, and retinal arteriolar and venular caliber, smaller retinal D f was correlated with elevated mean arterial blood pressure (P = 0.02), diastolic blood pressure (P = 0.02), and possibly systolic blood pressure (P = 0.06). CONCLUSIONS. Higher blood pressure in children is associated with smaller retinal D f, reflecting rarefaction of the retinal microvasculature. Retinal fractal analysis detects early subtle microvascular effects of elevated blood pressure, and may further the understanding of the genesis of ocular and systemic vascular complications of hypertension. © 2012 The Association for Research in Vision and Ophthalmology, Inc.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.subject.meshAdolescenten_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrocirculation - Physiologyen_US
dc.subject.meshMyopia - Diagnosisen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRetinal Vessels - Anatomy & Histology - Physiologyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.titleElevated blood pressure is associated with rarefaction of the retinal vasculature in childrenen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.11-8835en_US
dc.identifier.pmid22205607-
dc.identifier.scopuseid_2-s2.0-84858832649en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858832649&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume53en_US
dc.identifier.issue1en_US
dc.identifier.spage470en_US
dc.identifier.epage474en_US
dc.identifier.isiWOS:000302694500068-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKurniawan, ED=24461846400en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridCheung, CY=35276903300en_US
dc.identifier.scopusauthoridTay, WT=24391674800en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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