File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Retinal arteriolar tortuosity is associated with retinopathy and early kidney dysfunction in type 1 diabetes

TitleRetinal arteriolar tortuosity is associated with retinopathy and early kidney dysfunction in type 1 diabetes
Authors
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajo
Citation
American Journal Of Ophthalmology, 2012, v. 153 n. 1, p. 176-183.e1 How to Cite?
AbstractTo examine the association of retinal vessel tortuosity with diabetic retinopathy and early nephropathy in type 1 diabetes. Cross-sectional. A total of 1159 participants with type 1 diabetes aged 12 to 20 years, attending diabetes clinics in Children's Hospital at Westmead, Sydney, Australia between 1990 and 2002, were included. Retinal photography and clinical examinations were performed during the baseline visit to assess diabetic retinopathy and albumin excretion rate (AER). Retinal vessel tortuosity was measured from digitized retinal photographs using a semi-automated computer program by a single grader masked to participants' characteristics. Diabetic retinopathy was defined as ETDRS level <21 (mild nonproliferative retinopathy) and early kidney dysfunction was defined as AER <7.5 μg/min. Of 944 patients (81.4%), 85 (9.0%) had signs of retinopathy only, 250 (26.5%) had early kidney dysfunction only, and 85 (9.0%) had both retinopathy and early kidney dysfunction. In multivariate analysis, higher arteriolar tortuosity was associated with retinopathy (odds ratio [OR] 2.01, 95% confidence interval [CI] 1.23-3.29, the highest quartile vs the remaining 3 quartiles), early kidney dysfunction (OR 1.56, 95% CI 1.06-2.28, per standard deviation [SD] increase), or coexistence of both complications (OR 1.96, 95% CI 1.21-3.24, the highest quartile vs the remaining 3 quartiles). Greater retinal arteriolar tortuosity was independently associated with retinopathy and early stage of nephropathy in type 1 diabetes. These findings may offer the potential of quantitative measurement of retinal vessel tortuosity for diabetic complication risk assessment. © 2012 Elsevier Inc. All Right Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/183614
ISSN
2015 Impact Factor: 3.831
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSasongko, MBen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorDonaghue, KCen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorJenkins, AJen_US
dc.contributor.authorBenitezAguirre, Pen_US
dc.contributor.authorWang, JJen_US
dc.date.accessioned2013-05-28T06:15:25Z-
dc.date.available2013-05-28T06:15:25Z-
dc.date.issued2012en_US
dc.identifier.citationAmerican Journal Of Ophthalmology, 2012, v. 153 n. 1, p. 176-183.e1en_US
dc.identifier.issn0002-9394en_US
dc.identifier.urihttp://hdl.handle.net/10722/183614-
dc.description.abstractTo examine the association of retinal vessel tortuosity with diabetic retinopathy and early nephropathy in type 1 diabetes. Cross-sectional. A total of 1159 participants with type 1 diabetes aged 12 to 20 years, attending diabetes clinics in Children's Hospital at Westmead, Sydney, Australia between 1990 and 2002, were included. Retinal photography and clinical examinations were performed during the baseline visit to assess diabetic retinopathy and albumin excretion rate (AER). Retinal vessel tortuosity was measured from digitized retinal photographs using a semi-automated computer program by a single grader masked to participants' characteristics. Diabetic retinopathy was defined as ETDRS level <21 (mild nonproliferative retinopathy) and early kidney dysfunction was defined as AER <7.5 μg/min. Of 944 patients (81.4%), 85 (9.0%) had signs of retinopathy only, 250 (26.5%) had early kidney dysfunction only, and 85 (9.0%) had both retinopathy and early kidney dysfunction. In multivariate analysis, higher arteriolar tortuosity was associated with retinopathy (odds ratio [OR] 2.01, 95% confidence interval [CI] 1.23-3.29, the highest quartile vs the remaining 3 quartiles), early kidney dysfunction (OR 1.56, 95% CI 1.06-2.28, per standard deviation [SD] increase), or coexistence of both complications (OR 1.96, 95% CI 1.21-3.24, the highest quartile vs the remaining 3 quartiles). Greater retinal arteriolar tortuosity was independently associated with retinopathy and early stage of nephropathy in type 1 diabetes. These findings may offer the potential of quantitative measurement of retinal vessel tortuosity for diabetic complication risk assessment. © 2012 Elsevier Inc. All Right Reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajoen_US
dc.relation.ispartofAmerican Journal of Ophthalmologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshArterioles - Pathologyen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshChilden_US
dc.subject.meshCholesterol - Blooden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDiabetes Mellitus, Type 1 - Diagnosisen_US
dc.subject.meshDiabetic Nephropathies - Blood - Diagnosisen_US
dc.subject.meshDiabetic Retinopathy - Blood - Diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobin A, Glycosylated - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshRetinal Artery - Pathologyen_US
dc.subject.meshYoung Adulten_US
dc.titleRetinal arteriolar tortuosity is associated with retinopathy and early kidney dysfunction in type 1 diabetesen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ajo.2011.06.005en_US
dc.identifier.pmid21907319-
dc.identifier.scopuseid_2-s2.0-83555176181en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83555176181&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume153en_US
dc.identifier.issue1en_US
dc.identifier.spage176en_US
dc.identifier.epage183.e1en_US
dc.identifier.isiWOS:000298312700024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSasongko, MB=36100847400en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US
dc.identifier.scopusauthoridDonaghue, KC=7003470857en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridJenkins, AJ=7202458130en_US
dc.identifier.scopusauthoridBenitezAguirre, P=26535507200en_US
dc.identifier.scopusauthoridWang, JJ=35231432000en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats