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Article: Prevalence and risk factors for epiretinal membranes in a multi-ethnic United States population

TitlePrevalence and risk factors for epiretinal membranes in a multi-ethnic United States population
Authors
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2011, v. 118 n. 4, p. 694-699 How to Cite?
AbstractPurpose: To describe the prevalence of and risk factors for epiretinal membrane (ERM) in a multi-ethnic population and to evaluate possible racial or ethnic differences. Design: Cross-sectional study. Participants: Participants of the Multi-Ethnic Study of Atherosclerosis (MESA), examined at the second visit of the MESA when retinal photography was performed. Methods: Data on 5960 participants aged 45 to 84 years from MESA, including white, black, Hispanic, and Chinese persons from 6 United States communities, were analyzed. Epiretinal membrane was assessed from digital nonstereoscopic fundus photographs and was defined as cellophane macular reflex (CMR) without retinal folds or preretinal macular fibrosis (PMF) with retinal folds. Risk factors were assessed from standardized interviews, clinical examinations, and laboratory investigations. Main Outcome Measures: Epiretinal membrane prevalence by ethnic or racial group and risk factors associated with ERM. Results: The prevalence of any ERM was 28.9%, of which 25.1% were CMR cases and 3.8% were PMF cases. The prevalence of ERM was significantly higher in Chinese persons (39.0%), compared with Hispanic (29.3%), white (27.5%), or black (26.2%; P<0.001) persons. In multivariate models, increasing age (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.06-1.34, per year increase in age), diabetes (OR, 1.92; 95% CI, 1.39-2.65), and hypercholesterolemia (OR, 1.33; 95% CI, 1.04-1.69) were significantly associated with CMR. Conclusions: This study showed that ERM was significantly more common in Chinese persons compared with whites, blacks, and Hispanics. Risk factors for ERM were increasing age, presence of diabetes, and hypercholesterolemia. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2011 American Academy of Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183604
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, CHen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorIslam, AFMen_US
dc.contributor.authorKawasaki, Ren_US
dc.contributor.authorMeuer, SMen_US
dc.contributor.authorCotch, MFen_US
dc.contributor.authorKlein, BEKen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:17Z-
dc.date.available2013-05-28T06:15:17Z-
dc.date.issued2011en_US
dc.identifier.citationOphthalmology, 2011, v. 118 n. 4, p. 694-699en_US
dc.identifier.issn0161-6420en_US
dc.identifier.urihttp://hdl.handle.net/10722/183604-
dc.description.abstractPurpose: To describe the prevalence of and risk factors for epiretinal membrane (ERM) in a multi-ethnic population and to evaluate possible racial or ethnic differences. Design: Cross-sectional study. Participants: Participants of the Multi-Ethnic Study of Atherosclerosis (MESA), examined at the second visit of the MESA when retinal photography was performed. Methods: Data on 5960 participants aged 45 to 84 years from MESA, including white, black, Hispanic, and Chinese persons from 6 United States communities, were analyzed. Epiretinal membrane was assessed from digital nonstereoscopic fundus photographs and was defined as cellophane macular reflex (CMR) without retinal folds or preretinal macular fibrosis (PMF) with retinal folds. Risk factors were assessed from standardized interviews, clinical examinations, and laboratory investigations. Main Outcome Measures: Epiretinal membrane prevalence by ethnic or racial group and risk factors associated with ERM. Results: The prevalence of any ERM was 28.9%, of which 25.1% were CMR cases and 3.8% were PMF cases. The prevalence of ERM was significantly higher in Chinese persons (39.0%), compared with Hispanic (29.3%), white (27.5%), or black (26.2%; P<0.001) persons. In multivariate models, increasing age (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.06-1.34, per year increase in age), diabetes (OR, 1.92; 95% CI, 1.39-2.65), and hypercholesterolemia (OR, 1.33; 95% CI, 1.04-1.69) were significantly associated with CMR. Conclusions: This study showed that ERM was significantly more common in Chinese persons compared with whites, blacks, and Hispanics. Risk factors for ERM were increasing age, presence of diabetes, and hypercholesterolemia. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2011 American Academy of Ophthalmology.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_US
dc.relation.ispartofOphthalmologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshEpiretinal Membrane - Classification - Ethnology - Etiologyen_US
dc.subject.meshEthnic Groups - Statistics & Numerical Dataen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhotographyen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshUnited States - Epidemiologyen_US
dc.titlePrevalence and risk factors for epiretinal membranes in a multi-ethnic United States populationen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/j.ophtha.2010.08.009en_US
dc.identifier.pmid21035863-
dc.identifier.pmcidPMC3070851-
dc.identifier.scopuseid_2-s2.0-79953302585en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79953302585&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume118en_US
dc.identifier.issue4en_US
dc.identifier.spage694en_US
dc.identifier.epage699en_US
dc.identifier.isiWOS:000289075200013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNg, CH=36148056600en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWang, JJ=35231432000en_US
dc.identifier.scopusauthoridIslam, AFM=16033054600en_US
dc.identifier.scopusauthoridKawasaki, R=35229910100en_US
dc.identifier.scopusauthoridMeuer, SM=7102097693en_US
dc.identifier.scopusauthoridCotch, MF=6603036992en_US
dc.identifier.scopusauthoridKlein, BEK=35433541400en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridWong, TY=35231271400en_US

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