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Article: Blood pressure is associated with retinal vessel signs in preadolescent children

TitleBlood pressure is associated with retinal vessel signs in preadolescent children
Authors
Issue Date2010
PublisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/
Citation
Journal Of Hypertension, 2010, v. 28 n. 7, p. 1406-1412 How to Cite?
AbstractObjective: Few studies have examined the effect of blood pressure (BP) on the retinal microvasculature in children. We examined the relationship between BP and retinal vessel caliber in a sample of preadolescent schoolchildren. Methods: Eligible high school students [2353/3144 (response 75.3%); mean age, 12.7 years] from 21 randomly selected schools in Sydney, Australia, were examined during 2004-2005. Retinal vessel caliber was quantified from digital retinal images using well known computer-based programs. BP was measured using a standard protocol and high BP was defined according to published guidelines for this age group. Results: After adjusting for age, sex, ethnicity, BMI, iris color, axial length, birth weight and the fellow retinal vascular caliber, children in the highest quartiles of SBP, DBP or mean arterial BP had approximately 5 μm narrower mean retinal arteriolar caliber than those in the lowest quartiles of all three BP measures (all P for trend <0.0001). Children classified as having high BP had approximately 2.0 μm narrower mean retinal arteriolar caliber than normotensive children (P = 0.002). In boys, each 10-mmHg increase in SBP was associated with a 2.19-μm increase in the mean retinal venular caliber (P = 0.0003), but no similar significant association was evident in girls. Conclusion: Elevated BP is associated with narrower retinal arterioles in preadolescent boys and girls, and also with wider retinal venules in boys. These data provide further evidence of early microvascular changes associated with high BP in older children. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/183594
ISSN
2015 Impact Factor: 5.062
2015 SCImago Journal Rankings: 2.193
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGopinath, Ben_US
dc.contributor.authorBaur, LAen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorTeber, Een_US
dc.contributor.authorLiew, Gen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorMitchell, Pen_US
dc.date.accessioned2013-05-28T06:15:07Z-
dc.date.available2013-05-28T06:15:07Z-
dc.date.issued2010en_US
dc.identifier.citationJournal Of Hypertension, 2010, v. 28 n. 7, p. 1406-1412en_US
dc.identifier.issn0263-6352en_US
dc.identifier.urihttp://hdl.handle.net/10722/183594-
dc.description.abstractObjective: Few studies have examined the effect of blood pressure (BP) on the retinal microvasculature in children. We examined the relationship between BP and retinal vessel caliber in a sample of preadolescent schoolchildren. Methods: Eligible high school students [2353/3144 (response 75.3%); mean age, 12.7 years] from 21 randomly selected schools in Sydney, Australia, were examined during 2004-2005. Retinal vessel caliber was quantified from digital retinal images using well known computer-based programs. BP was measured using a standard protocol and high BP was defined according to published guidelines for this age group. Results: After adjusting for age, sex, ethnicity, BMI, iris color, axial length, birth weight and the fellow retinal vascular caliber, children in the highest quartiles of SBP, DBP or mean arterial BP had approximately 5 μm narrower mean retinal arteriolar caliber than those in the lowest quartiles of all three BP measures (all P for trend <0.0001). Children classified as having high BP had approximately 2.0 μm narrower mean retinal arteriolar caliber than normotensive children (P = 0.002). In boys, each 10-mmHg increase in SBP was associated with a 2.19-μm increase in the mean retinal venular caliber (P = 0.0003), but no similar significant association was evident in girls. Conclusion: Elevated BP is associated with narrower retinal arterioles in preadolescent boys and girls, and also with wider retinal venules in boys. These data provide further evidence of early microvascular changes associated with high BP in older children. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/en_US
dc.relation.ispartofJournal of Hypertensionen_US
dc.subject.meshBirth Weighten_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshCardiovascular Diseases - Physiopathologyen_US
dc.subject.meshChilden_US
dc.subject.meshEthnic Groupsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshHypotension - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRetinal Vessels - Anatomy & Histologyen_US
dc.subject.meshVenules - Physiopathologyen_US
dc.titleBlood pressure is associated with retinal vessel signs in preadolescent childrenen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/HJH.0b013e3283395223en_US
dc.identifier.pmid20410837-
dc.identifier.scopuseid_2-s2.0-77954386362en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954386362&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue7en_US
dc.identifier.spage1406en_US
dc.identifier.epage1412en_US
dc.identifier.isiWOS:000279579800012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridGopinath, B=15829811000en_US
dc.identifier.scopusauthoridBaur, LA=7005262888en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridTeber, E=6508372989en_US
dc.identifier.scopusauthoridLiew, G=12796147900en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWong, TY=35231271400en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US

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