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Article: Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: A prospective study

TitleRetinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: A prospective study
Authors
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://brain.oxfordjournals.org/
Citation
Brain, 2010, v. 133 n. 7, p. 1987-1993 How to Cite?
AbstractSilent brain infarct and white matter lesions are common radiological findings associated with the risk of clinical stroke and dementia; however, our understanding of their underlying pathophysiology and risk factors remains limited. This study aimed to determine whether assessment of retinal microvascular abnormalities could provide prognostic information regarding the risk of brain infarct and white matter lesions on magnetic resonance imaging. This study is based on a subset of 810 middle-aged persons without clinical stroke or baseline magnetic resonance imaging infarct enrolled in the Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging Study, a prospective, population-based study. Participants had a baseline magnetic resonance imaging brain examination and retinal photography in 1993-1995, and returned for a repeat magnetic resonance imaging examination in 2004-2006. Magnetic resonance images were graded for presence of any cerebral infarct, infarct with lacunar characteristics and white matter lesions according to standardized protocols. Retinal photographs were graded for presence of retinopathy lesions and retinal arteriolar abnormalities following a standardized protocol. Over a median follow-up of 10.5 years, 164 (20.2) participants developed cerebral infarct, 131 (16.2) developed lacunar infarct, 182 (24.2) developed new white matter lesions and 49 (6.1) had evidence of white matter lesion progression. After adjusting for age, gender, race, cardiovascular risk factors and carotid intima-media thickness, retinopathy was associated with incident cerebral infarct (odds ratio 2.82; 95 confidence interval 1.42-5.60) and lacunar infarct (odds ratio 3.19; 95 confidence interval: 1.56-6.50). Retinal arteriovenous nicking was associated with incident cerebral infarct (odds ratio 2.82; 95 confidence interval: 1.66-4.76), lacunar infarct (odds ratio 2.48; 95 confidence interval: 1.39-4.40) and white matter lesion incidence (odds ratio 2.12; 95 confidence interval: 1.18-3.81) and progression (odds ratio 2.22; 95 confidence interval: 1.00-5.88). In conclusion, retinal microvascular abnormalities are associated with emergence of subclinical magnetic resonance imaging brain infarcts and white matter lesions, independent of shared risk factors. Retinal vascular imaging may offer a non-invasive tool to investigate the pathogenesis and natural history of cerebral small-vessel disease. © 2010 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/183593
ISSN
2015 Impact Factor: 10.103
2015 SCImago Journal Rankings: 6.097
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorMosley, Ten_US
dc.contributor.authorIslam, Aen_US
dc.contributor.authorKawasaki, Ren_US
dc.contributor.authorSharrett, ARen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorCoker, LHen_US
dc.contributor.authorKnopman, DSen_US
dc.contributor.authorShibata, DKen_US
dc.contributor.authorCatellier, Den_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:07Z-
dc.date.available2013-05-28T06:15:07Z-
dc.date.issued2010en_US
dc.identifier.citationBrain, 2010, v. 133 n. 7, p. 1987-1993en_US
dc.identifier.issn0006-8950en_US
dc.identifier.urihttp://hdl.handle.net/10722/183593-
dc.description.abstractSilent brain infarct and white matter lesions are common radiological findings associated with the risk of clinical stroke and dementia; however, our understanding of their underlying pathophysiology and risk factors remains limited. This study aimed to determine whether assessment of retinal microvascular abnormalities could provide prognostic information regarding the risk of brain infarct and white matter lesions on magnetic resonance imaging. This study is based on a subset of 810 middle-aged persons without clinical stroke or baseline magnetic resonance imaging infarct enrolled in the Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging Study, a prospective, population-based study. Participants had a baseline magnetic resonance imaging brain examination and retinal photography in 1993-1995, and returned for a repeat magnetic resonance imaging examination in 2004-2006. Magnetic resonance images were graded for presence of any cerebral infarct, infarct with lacunar characteristics and white matter lesions according to standardized protocols. Retinal photographs were graded for presence of retinopathy lesions and retinal arteriolar abnormalities following a standardized protocol. Over a median follow-up of 10.5 years, 164 (20.2) participants developed cerebral infarct, 131 (16.2) developed lacunar infarct, 182 (24.2) developed new white matter lesions and 49 (6.1) had evidence of white matter lesion progression. After adjusting for age, gender, race, cardiovascular risk factors and carotid intima-media thickness, retinopathy was associated with incident cerebral infarct (odds ratio 2.82; 95 confidence interval 1.42-5.60) and lacunar infarct (odds ratio 3.19; 95 confidence interval: 1.56-6.50). Retinal arteriovenous nicking was associated with incident cerebral infarct (odds ratio 2.82; 95 confidence interval: 1.66-4.76), lacunar infarct (odds ratio 2.48; 95 confidence interval: 1.39-4.40) and white matter lesion incidence (odds ratio 2.12; 95 confidence interval: 1.18-3.81) and progression (odds ratio 2.22; 95 confidence interval: 1.00-5.88). In conclusion, retinal microvascular abnormalities are associated with emergence of subclinical magnetic resonance imaging brain infarcts and white matter lesions, independent of shared risk factors. Retinal vascular imaging may offer a non-invasive tool to investigate the pathogenesis and natural history of cerebral small-vessel disease. © 2010 The Author(s).en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://brain.oxfordjournals.org/en_US
dc.relation.ispartofBrainen_US
dc.subject.meshAgeden_US
dc.subject.meshCerebral Infarction - Diagnosis - Etiology - Physiopathologyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrovessels - Abnormalities - Pathologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRetinal Diseases - Complications - Diagnosis - Physiopathologyen_US
dc.subject.meshRetinal Vessels - Abnormalities - Pathologyen_US
dc.subject.meshRisk Factorsen_US
dc.titleRetinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: A prospective studyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1093/brain/awq127en_US
dc.identifier.pmid20519327-
dc.identifier.pmcidPMC2912690-
dc.identifier.scopuseid_2-s2.0-77954350277en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954350277&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume133en_US
dc.identifier.issue7en_US
dc.identifier.spage1987en_US
dc.identifier.epage1993en_US
dc.identifier.isiWOS:000279473900012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridMosley, T=6603754517en_US
dc.identifier.scopusauthoridIslam, A=16033054600en_US
dc.identifier.scopusauthoridKawasaki, R=35229910100en_US
dc.identifier.scopusauthoridSharrett, AR=7006662570en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridCoker, LH=7003840574en_US
dc.identifier.scopusauthoridKnopman, DS=7004497868en_US
dc.identifier.scopusauthoridShibata, DK=7102096855en_US
dc.identifier.scopusauthoridCatellier, D=6604075920en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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