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Article: Natural History of Central Retinal Vein Occlusion: An Evidence-Based Systematic Review

TitleNatural History of Central Retinal Vein Occlusion: An Evidence-Based Systematic Review
Authors
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2010, v. 117 n. 6, p. 1113-1123.e15 How to Cite?
AbstractObjective: To describe the natural history of central retinal vein occlusion (CRVO) based on the best available evidence from the literature. Clinical Relevance: Central retinal vein occlusion is a common sight-threatening retinal vascular disease. Despite the introduction of new interventions, the natural history of CRVO is unclear. Methods: Systemic review of all English language articles retrieved using a keyword search of MEDLINE, EMBASE, Current Contents, and the Cochrane Library to November 13, 2008. This was supplemented by hand-searching references of review articles published within the last 5 years. Two investigators independently identified all relevant observational studies evaluating the natural history of RVO and all clinical trials evaluating interventions for CRVO; an untreated control arm was included. Results: Of 5966 citations retrieved, 53 studies were reviewed, providing 3271 eyes with CRVO for analysis of its natural history. Visual acuity (VA) was generally poor at baseline (<20/40) and decreased further over time. Although 6 studies reported an improvement in VA, none of these improvements resulted in VA better than 20/40. Up to 34% of eyes with nonischemic CRVO converted to ischemic CRVO over a 3-year period. In ischemic CRVO cases, neovascular glaucoma developed in at least 23% of eyes within 15 months. In nonischemic CRVO cases, macular edema resolved in approximately 30% of eyes over time, and subsequent neovascular glaucoma was rare. Conclusions: Untreated eyes with CRVO generally had poor VA, which declined further over time. One quarter of eyes with nonischemic CRVO converted to ischemic CRVO. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. © 2010 American Academy of Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183590
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
References

 

DC FieldValueLanguage
dc.contributor.authorMcintosh, RLen_US
dc.contributor.authorRogers, SLen_US
dc.contributor.authorLim, Len_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorKowalski, JWen_US
dc.contributor.authorNguyen, HPen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:04Z-
dc.date.available2013-05-28T06:15:04Z-
dc.date.issued2010en_US
dc.identifier.citationOphthalmology, 2010, v. 117 n. 6, p. 1113-1123.e15en_US
dc.identifier.issn0161-6420en_US
dc.identifier.urihttp://hdl.handle.net/10722/183590-
dc.description.abstractObjective: To describe the natural history of central retinal vein occlusion (CRVO) based on the best available evidence from the literature. Clinical Relevance: Central retinal vein occlusion is a common sight-threatening retinal vascular disease. Despite the introduction of new interventions, the natural history of CRVO is unclear. Methods: Systemic review of all English language articles retrieved using a keyword search of MEDLINE, EMBASE, Current Contents, and the Cochrane Library to November 13, 2008. This was supplemented by hand-searching references of review articles published within the last 5 years. Two investigators independently identified all relevant observational studies evaluating the natural history of RVO and all clinical trials evaluating interventions for CRVO; an untreated control arm was included. Results: Of 5966 citations retrieved, 53 studies were reviewed, providing 3271 eyes with CRVO for analysis of its natural history. Visual acuity (VA) was generally poor at baseline (<20/40) and decreased further over time. Although 6 studies reported an improvement in VA, none of these improvements resulted in VA better than 20/40. Up to 34% of eyes with nonischemic CRVO converted to ischemic CRVO over a 3-year period. In ischemic CRVO cases, neovascular glaucoma developed in at least 23% of eyes within 15 months. In nonischemic CRVO cases, macular edema resolved in approximately 30% of eyes over time, and subsequent neovascular glaucoma was rare. Conclusions: Untreated eyes with CRVO generally had poor VA, which declined further over time. One quarter of eyes with nonischemic CRVO converted to ischemic CRVO. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. © 2010 American Academy of Ophthalmology.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_US
dc.relation.ispartofOphthalmologyen_US
dc.subject.meshHumansen_US
dc.subject.meshRetinal Vein - Physiopathologyen_US
dc.subject.meshRetinal Vein Occlusion - Physiopathologyen_US
dc.subject.meshVisual Acuity - Physiologyen_US
dc.titleNatural History of Central Retinal Vein Occlusion: An Evidence-Based Systematic Reviewen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ophtha.2010.01.060en_US
dc.identifier.pmid20430446-
dc.identifier.scopuseid_2-s2.0-77952890912en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952890912&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume117en_US
dc.identifier.issue6en_US
dc.identifier.spage1113en_US
dc.identifier.epage1123.e15en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMcIntosh, RL=55166106200en_US
dc.identifier.scopusauthoridRogers, SL=12768398500en_US
dc.identifier.scopusauthoridLim, L=15053336200en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridKowalski, JW=8243072500en_US
dc.identifier.scopusauthoridNguyen, HP=35741469200en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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