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Article: Hepatocyte Growth Factor and Retinal Arteriolar Diameter in Singapore Chinese

TitleHepatocyte Growth Factor and Retinal Arteriolar Diameter in Singapore Chinese
Authors
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2010, v. 117 n. 5, p. 939-945 How to Cite?
AbstractObjective: To assess if natural genetic variation in hepatocyte growth factor (HGF) is associated with altered retinal vessel diameter. Design: Two-stage cohort study. Participants and Controls: Discovery set (set 1, n = 682 children) and confirmatory set (set 2, n = 1293 adults). Methods: Children in the discovery set were genotyped for a panel of genetic markers within HGF. Markers that were found to be associated significantly with altered retinal vessel diameter then were genotyped in the confirmatory set. Main Outcome Measures: Increased or decreased retinal vessel diameter. Results: In the discovery set (n = 682 Chinese children aged 7 to 12 years), the variant allele of 4 HGF single nucleotide polymorphisms (SNPs) demonstrated association with larger retinal arteriolar diameter. The effect of the variant allele seems to be strongest within a recessive model of inheritance (Pmin = 4.6×10-3) for all 4 SNPs. When these 4 SNPs were assessed in a confirmatory study comprising 1293 Chinese adults, successful replication was observed for one of them (HGF +63962; rs5745752); the variant allele was observed to correlate with significantly larger retinal arteriolar diameter, with its effect again strongest within a model of recessive inheritance (P = 0.049). Analyzed as a quantitative trait, recessive carriage at HGF +63962 resulted in on average a 3.5-μm increase in retinal arteriolar diameter among children and a 2.5-μm increase in adults (P = 7.0×10-3, analysis of variance; P = 3.0×10-3, Kruskal-Wallis test). Conclusions: This study suggests that natural variation within HGF is involved in the control of retinal arteriolar diameter and may be important in the pathogenesis of microvascular disease in individuals of Chinese descent. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2010 American Academy of Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183588
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKhor, CCen_US
dc.contributor.authorFan, Qen_US
dc.contributor.authorGoh, LKen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorLi, YJen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorSeielstad, Men_US
dc.contributor.authorGoh, DLMen_US
dc.contributor.authorYoung, TLen_US
dc.contributor.authorTai, ESen_US
dc.contributor.authorSaw, SMen_US
dc.date.accessioned2013-05-28T06:15:02Z-
dc.date.available2013-05-28T06:15:02Z-
dc.date.issued2010en_US
dc.identifier.citationOphthalmology, 2010, v. 117 n. 5, p. 939-945en_US
dc.identifier.issn0161-6420en_US
dc.identifier.urihttp://hdl.handle.net/10722/183588-
dc.description.abstractObjective: To assess if natural genetic variation in hepatocyte growth factor (HGF) is associated with altered retinal vessel diameter. Design: Two-stage cohort study. Participants and Controls: Discovery set (set 1, n = 682 children) and confirmatory set (set 2, n = 1293 adults). Methods: Children in the discovery set were genotyped for a panel of genetic markers within HGF. Markers that were found to be associated significantly with altered retinal vessel diameter then were genotyped in the confirmatory set. Main Outcome Measures: Increased or decreased retinal vessel diameter. Results: In the discovery set (n = 682 Chinese children aged 7 to 12 years), the variant allele of 4 HGF single nucleotide polymorphisms (SNPs) demonstrated association with larger retinal arteriolar diameter. The effect of the variant allele seems to be strongest within a recessive model of inheritance (Pmin = 4.6×10-3) for all 4 SNPs. When these 4 SNPs were assessed in a confirmatory study comprising 1293 Chinese adults, successful replication was observed for one of them (HGF +63962; rs5745752); the variant allele was observed to correlate with significantly larger retinal arteriolar diameter, with its effect again strongest within a model of recessive inheritance (P = 0.049). Analyzed as a quantitative trait, recessive carriage at HGF +63962 resulted in on average a 3.5-μm increase in retinal arteriolar diameter among children and a 2.5-μm increase in adults (P = 7.0×10-3, analysis of variance; P = 3.0×10-3, Kruskal-Wallis test). Conclusions: This study suggests that natural variation within HGF is involved in the control of retinal arteriolar diameter and may be important in the pathogenesis of microvascular disease in individuals of Chinese descent. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2010 American Academy of Ophthalmology.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_US
dc.relation.ispartofOphthalmologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshArterioles - Pathologyen_US
dc.subject.meshAsian Continental Ancestry Group - Ethnologyen_US
dc.subject.meshCardiovascular Diseases - Geneticsen_US
dc.subject.meshChilden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatocyte Growth Factor - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyopia - Geneticsen_US
dc.subject.meshPhotographyen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshRetinal Artery - Pathologyen_US
dc.subject.meshSingapore - Epidemiologyen_US
dc.titleHepatocyte Growth Factor and Retinal Arteriolar Diameter in Singapore Chineseen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ophtha.2009.09.055en_US
dc.identifier.pmid20122738-
dc.identifier.scopuseid_2-s2.0-77951622840en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951622840&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume117en_US
dc.identifier.issue5en_US
dc.identifier.spage939en_US
dc.identifier.epage945en_US
dc.identifier.isiWOS:000277261800014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKhor, CC=13404065800en_US
dc.identifier.scopusauthoridFan, Q=26429395500en_US
dc.identifier.scopusauthoridGoh, LK=7004436167en_US
dc.identifier.scopusauthoridWong, TY=35231271400en_US
dc.identifier.scopusauthoridLi, YJ=53163988500en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridSeielstad, M=6602617241en_US
dc.identifier.scopusauthoridGoh, DLM=7007069955en_US
dc.identifier.scopusauthoridYoung, TL=7403038028en_US
dc.identifier.scopusauthoridTai, ES=7005660980en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US

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