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Article: Prevalence and risk factors of retinopathy in an Asian population without diabetes: The Singapore Malay eye study

TitlePrevalence and risk factors of retinopathy in an Asian population without diabetes: The Singapore Malay eye study
Authors
Issue Date2010
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archopthalmol.com
Citation
Archives Of Ophthalmology, 2010, v. 128 n. 1, p. 40-45 How to Cite?
AbstractObjective: To describe the prevalence and risk factors of retinopathy in an Asian population without diabetes. Methods: We conducted a population-based, crosssectional study of 3280 Malays aged 40 to 80 years residing in Singapore. Participants had retinal photographs taken, which were graded for retinopathy signs using the modified Airlie House Classification System. Risk factors were assessed from standardized interviews, clinical examinations, and laboratory investigations. Results: Of participants without diabetes (n=2500), 149 (6.0%; 95% confidence interval [CI], 5.0-6.9) had signs of retinopathy that represented minimal (5.8%) or mild (0.2%) retinopathy. After adjusting for multiple covariables, higher serum glucose levels (odds ratio [OR], 1.13; 95% CI, 1.00-1.28; per millimole per liter increase), higher systolic blood pressure (OR, 1.15; 95% CI, 1.06-1.25; per 10-mm Hg increase), higher body mass index (OR, 1.04; 95% CI, 1.00-1.07 per point increase), and a history of heart attack (OR, 2.68; 95% CI, 1.48-4.83) were significantly associated with the presence of retinopathy lesions in persons without diabetes. Conclusions: Similar to studies in white individuals, signs of retinopathy are common in Asian persons without diabetes. Early signs of retinopathy in persons without diabetes are related to metabolic and vascular risk factors and may indicate intermediate pathologic changes along the pathway to cardiovascular disease. ©2010 American Medical Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/183585
ISSN
2014 Impact Factor: 4.399
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJeganathan, VSEen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorTay, WTen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:00Z-
dc.date.available2013-05-28T06:15:00Z-
dc.date.issued2010en_US
dc.identifier.citationArchives Of Ophthalmology, 2010, v. 128 n. 1, p. 40-45en_US
dc.identifier.issn0003-9950en_US
dc.identifier.urihttp://hdl.handle.net/10722/183585-
dc.description.abstractObjective: To describe the prevalence and risk factors of retinopathy in an Asian population without diabetes. Methods: We conducted a population-based, crosssectional study of 3280 Malays aged 40 to 80 years residing in Singapore. Participants had retinal photographs taken, which were graded for retinopathy signs using the modified Airlie House Classification System. Risk factors were assessed from standardized interviews, clinical examinations, and laboratory investigations. Results: Of participants without diabetes (n=2500), 149 (6.0%; 95% confidence interval [CI], 5.0-6.9) had signs of retinopathy that represented minimal (5.8%) or mild (0.2%) retinopathy. After adjusting for multiple covariables, higher serum glucose levels (odds ratio [OR], 1.13; 95% CI, 1.00-1.28; per millimole per liter increase), higher systolic blood pressure (OR, 1.15; 95% CI, 1.06-1.25; per 10-mm Hg increase), higher body mass index (OR, 1.04; 95% CI, 1.00-1.07 per point increase), and a history of heart attack (OR, 2.68; 95% CI, 1.48-4.83) were significantly associated with the presence of retinopathy lesions in persons without diabetes. Conclusions: Similar to studies in white individuals, signs of retinopathy are common in Asian persons without diabetes. Early signs of retinopathy in persons without diabetes are related to metabolic and vascular risk factors and may indicate intermediate pathologic changes along the pathway to cardiovascular disease. ©2010 American Medical Association. All rights reserved.en_US
dc.languageengen_US
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archopthalmol.comen_US
dc.relation.ispartofArchives of Ophthalmologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAsian Continental Ancestry Group - Ethnologyen_US
dc.subject.meshBlood Glucose - Analysisen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDiabetes Mellitus - Ethnologyen_US
dc.subject.meshDiabetic Retinopathy - Ethnology - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSingapore - Epidemiologyen_US
dc.titlePrevalence and risk factors of retinopathy in an Asian population without diabetes: The Singapore Malay eye studyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1001/archophthalmol.2009.330en_US
dc.identifier.pmid20065215-
dc.identifier.scopuseid_2-s2.0-75349092333en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75349092333&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume128en_US
dc.identifier.issue1en_US
dc.identifier.spage40en_US
dc.identifier.epage45en_US
dc.identifier.isiWOS:000273532800005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJeganathan, VSE=25646126000en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridTay, WT=24391674800en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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