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Article: Retinal vessel diameters and risk of hypertension: The Multiethnic Study of Atherosclerosis

TitleRetinal vessel diameters and risk of hypertension: The Multiethnic Study of Atherosclerosis
Authors
Issue Date2009
PublisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/
Citation
Journal Of Hypertension, 2009, v. 27 n. 12, p. 2386-2393 How to Cite?
AbstractOBJECTIVE: To describe the prospective relationship of retinal vessel diameters with risk of hypertension in a multiethnic population-based cohort. METHODS: The Multi-Ethnic Study of Atherosclerosis is a population-based study of subclinical cardiovascular disease among white, Africanĝ€" American, Hispanic, and Chinese American adults aged 45ĝ€"84 years. Retinal vessel diameters were measured using a standardized imaging software at the second examination (considered baseline in this analysis) and summarized as the central retinal artery/vein equivalent. Presence of retinopathy and retinal focal arteriolar narrowing and arteriovenous nicking was assessed by trained graders. Incidence of hypertension was defined among participants at risk as systolic blood pressure at least 140 mmHg, diastolic blood pressure at least 90 mmHg, or use of an antihypertensive medication. RESULTS: Of the initial 6237 participants at baseline, 2583 were at risk of hypertension. After 3.2 ± 0.5 years of follow-up, 448 (17.3%) participants developed hypertension. After adjusting for age, sex, race/ethnicity, the average of mean arterial blood pressure in the first and second examination, and other vascular risk factors, persons with narrower retinal arteriolar diameter and wider venular diameter at baseline were more likely to develop hypertension [odds ratio per SD decrease in central retinal artery equivalent 1.20, 95% confidence intervals 1.02, 1.42; and odds ratio per SD increase in central retinal vein equivalent 1.18, 95% confidence interval 1.02, 1.37]. Persons with focal arteriolar narrowing were also more likely to develop hypertension (odds ratio 1.80, 95% confidence interval 1.09, 2.97). CONCLUSION: Findings from this multiethnic population confirm that narrower retinal arteriolar diameter and wider venular diameter are associated with the development of hypertension independent of traditional risk factors. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/183582
ISSN
2015 Impact Factor: 5.062
2015 SCImago Journal Rankings: 2.193
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKawasaki, Ren_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorKlein, BEen_US
dc.contributor.authorCotch, MFen_US
dc.contributor.authorSharrett, ARen_US
dc.contributor.authorShea, Sen_US
dc.contributor.authorIslam, FAen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:58Z-
dc.date.available2013-05-28T06:14:58Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Hypertension, 2009, v. 27 n. 12, p. 2386-2393en_US
dc.identifier.issn0263-6352en_US
dc.identifier.urihttp://hdl.handle.net/10722/183582-
dc.description.abstractOBJECTIVE: To describe the prospective relationship of retinal vessel diameters with risk of hypertension in a multiethnic population-based cohort. METHODS: The Multi-Ethnic Study of Atherosclerosis is a population-based study of subclinical cardiovascular disease among white, Africanĝ€" American, Hispanic, and Chinese American adults aged 45ĝ€"84 years. Retinal vessel diameters were measured using a standardized imaging software at the second examination (considered baseline in this analysis) and summarized as the central retinal artery/vein equivalent. Presence of retinopathy and retinal focal arteriolar narrowing and arteriovenous nicking was assessed by trained graders. Incidence of hypertension was defined among participants at risk as systolic blood pressure at least 140 mmHg, diastolic blood pressure at least 90 mmHg, or use of an antihypertensive medication. RESULTS: Of the initial 6237 participants at baseline, 2583 were at risk of hypertension. After 3.2 ± 0.5 years of follow-up, 448 (17.3%) participants developed hypertension. After adjusting for age, sex, race/ethnicity, the average of mean arterial blood pressure in the first and second examination, and other vascular risk factors, persons with narrower retinal arteriolar diameter and wider venular diameter at baseline were more likely to develop hypertension [odds ratio per SD decrease in central retinal artery equivalent 1.20, 95% confidence intervals 1.02, 1.42; and odds ratio per SD increase in central retinal vein equivalent 1.18, 95% confidence interval 1.02, 1.37]. Persons with focal arteriolar narrowing were also more likely to develop hypertension (odds ratio 1.80, 95% confidence interval 1.09, 2.97). CONCLUSION: Findings from this multiethnic population confirm that narrower retinal arteriolar diameter and wider venular diameter are associated with the development of hypertension independent of traditional risk factors. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/en_US
dc.relation.ispartofJournal of Hypertensionen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAtherosclerosis - Ethnology - Etiology - Pathologyen_US
dc.subject.meshCapillaries - Pathologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Diagnosis - Ethnology - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrocirculation - Physiologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshRetinal Diseases - Diagnosis - Ethnology - Physiopathologyen_US
dc.subject.meshRetinal Vessels - Pathologyen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshUnited States - Ethnologyen_US
dc.subject.meshVasoconstriction - Physiologyen_US
dc.titleRetinal vessel diameters and risk of hypertension: The Multiethnic Study of Atherosclerosisen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1097/HJH.0b013e3283310f7een_US
dc.identifier.pmid19680136-
dc.identifier.pmcidPMC2935621-
dc.identifier.scopuseid_2-s2.0-73649137207en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73649137207&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue12en_US
dc.identifier.spage2386en_US
dc.identifier.epage2393en_US
dc.identifier.isiWOS:000272420800013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKawasaki, R=35229910100en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridKlein, BE=35433541400en_US
dc.identifier.scopusauthoridCotch, MF=6603036992en_US
dc.identifier.scopusauthoridSharrett, AR=7006662570en_US
dc.identifier.scopusauthoridShea, S=7101777041en_US
dc.identifier.scopusauthoridIslam, FA=55399085000en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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