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Article: Relationship of Retinal Vascular Caliber with Optic Disc and Macular Structure

TitleRelationship of Retinal Vascular Caliber with Optic Disc and Macular Structure
Authors
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajo
Citation
American Journal Of Ophthalmology, 2009, v. 148 n. 3, p. 368-375 How to Cite?
AbstractPurpose: To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT). Design: Observational cross-sectional study. Methods: This study included a subset of healthy children enrolled in the Singapore Cohort Study of the Risk Factors of Myopia (SCORM). Optic disc, macular, and RNFL morphology were measured with Stratus OCT 3. Digital retinal photography was performed and retinal arteriolar and venular caliber measured using validated imaging software. Results: One hundred and four children (mean age 11.51 ± 0.52 years; 50% male) were included. In multivariate analyses, smaller horizontal integrated rim width and rim area were associated with narrower retinal arterioles and venules (all P < .05), and shorter horizontal rim length was associated with narrower venules (P = .04). Optic disc diameter was not associated with arteriolar or venular caliber. Larger vertical cup-to-disc ratios and cup-to-disc-area ratios were associated with narrower venules but not arterioles (P = .01 and P = .003, respectively). A thinner average RNFL measurement was associated with narrower arterioles and venules, and smaller total macular volume was associated with narrower venules. Conclusions: Thinner optic disc rims and RNFL measurements were associated with narrower retinal arterioles and venules, and larger cup-to-disc ratios with narrower venules. These findings suggest that retinal vessel caliber varies systematically with morphologic differences in the optic nerve head, retina, and macula. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/183577
ISSN
2015 Impact Factor: 3.831
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLim, LSen_US
dc.contributor.authorSaw, SMen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:54Z-
dc.date.available2013-05-28T06:14:54Z-
dc.date.issued2009en_US
dc.identifier.citationAmerican Journal Of Ophthalmology, 2009, v. 148 n. 3, p. 368-375en_US
dc.identifier.issn0002-9394en_US
dc.identifier.urihttp://hdl.handle.net/10722/183577-
dc.description.abstractPurpose: To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT). Design: Observational cross-sectional study. Methods: This study included a subset of healthy children enrolled in the Singapore Cohort Study of the Risk Factors of Myopia (SCORM). Optic disc, macular, and RNFL morphology were measured with Stratus OCT 3. Digital retinal photography was performed and retinal arteriolar and venular caliber measured using validated imaging software. Results: One hundred and four children (mean age 11.51 ± 0.52 years; 50% male) were included. In multivariate analyses, smaller horizontal integrated rim width and rim area were associated with narrower retinal arterioles and venules (all P < .05), and shorter horizontal rim length was associated with narrower venules (P = .04). Optic disc diameter was not associated with arteriolar or venular caliber. Larger vertical cup-to-disc ratios and cup-to-disc-area ratios were associated with narrower venules but not arterioles (P = .01 and P = .003, respectively). A thinner average RNFL measurement was associated with narrower arterioles and venules, and smaller total macular volume was associated with narrower venules. Conclusions: Thinner optic disc rims and RNFL measurements were associated with narrower retinal arterioles and venules, and larger cup-to-disc ratios with narrower venules. These findings suggest that retinal vessel caliber varies systematically with morphologic differences in the optic nerve head, retina, and macula. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajoen_US
dc.relation.ispartofAmerican Journal of Ophthalmologyen_US
dc.subject.meshAsian Continental Ancestry Group - Ethnologyen_US
dc.subject.meshChilden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve Fibersen_US
dc.subject.meshOptic Disk - Anatomy & Histologyen_US
dc.subject.meshPhotographyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRefraction, Ocular - Physiologyen_US
dc.subject.meshRetinal Ganglion Cells - Cytologyen_US
dc.subject.meshRetinal Vessels - Anatomy & Histologyen_US
dc.subject.meshSingaporeen_US
dc.subject.meshTomography, Optical Coherenceen_US
dc.titleRelationship of Retinal Vascular Caliber with Optic Disc and Macular Structureen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ajo.2009.04.006en_US
dc.identifier.pmid19481730-
dc.identifier.scopuseid_2-s2.0-68949147933en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68949147933&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume148en_US
dc.identifier.issue3en_US
dc.identifier.spage368en_US
dc.identifier.epage375en_US
dc.identifier.isiWOS:000269755400007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLim, LS=8721287400en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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