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Article: Vital exhaustion and retinal microvascular changes in cardiovascular disease: Atherosclerosis risk in communities study

TitleVital exhaustion and retinal microvascular changes in cardiovascular disease: Atherosclerosis risk in communities study
Authors
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychosomaticmedicine.org/
Citation
Psychosomatic Medicine, 2009, v. 71 n. 3, p. 308-312 How to Cite?
AbstractOBJECTIVE:: To determine if vital exhaustion, a measure of negative emotion, is associated with microvascular changes in the retina. Negative psychological factors, such as depression, have been implicated in the development of cardiovascular disease. Whether this link is mediated by macrovascular or microvascular disease is unknown. METHODS:: We performed a population-based, cross-sectional study of 10,364 White and African Americans aged 48 to 73 years. Vital exhaustion scores were determined from the Maastricht questionnaire and categorized into quartiles. Retinopathy signs and retinal vascular caliber were graded from retinal photographs following standardized protocols. RESULTS:: After adjusting for age, gender, race, study center, education, smoking, blood pressure, diabetes, and other risk factors, higher vital exhaustion scores (highest versus lowest quartiles) were associated modestly with the presence of retinopathy (odds ratio [OR] = 1.27; 95% Confidence Interval [CI] = 1.01-1.59), particularly retinal hemorrhages (OR = 1.71; 95% CI = 1.20-2.44), and with generalized retinal venular widening (OR = 1.19; 95% CI = 1.03-1.38). Analyzing vital exhaustion as a continuous variable did not change the pattern of the associations. CONCLUSIONS:: Middle-aged people with vital exhaustion may be more likely to have retinopathy signs that have been identified as risk predictors of cardiovascular events. Further research is needed to explore the possible adverse effects of negative emotion on the microcirculation. Copyright © 2009 by the American Psychosomatic Society.
Persistent Identifierhttp://hdl.handle.net/10722/183576
ISSN
2015 Impact Factor: 3.638
2015 SCImago Journal Rankings: 1.789
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorRogers, Sen_US
dc.contributor.authorMosley, THen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorCouper, Den_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:53Z-
dc.date.available2013-05-28T06:14:53Z-
dc.date.issued2009en_US
dc.identifier.citationPsychosomatic Medicine, 2009, v. 71 n. 3, p. 308-312en_US
dc.identifier.issn0033-3174en_US
dc.identifier.urihttp://hdl.handle.net/10722/183576-
dc.description.abstractOBJECTIVE:: To determine if vital exhaustion, a measure of negative emotion, is associated with microvascular changes in the retina. Negative psychological factors, such as depression, have been implicated in the development of cardiovascular disease. Whether this link is mediated by macrovascular or microvascular disease is unknown. METHODS:: We performed a population-based, cross-sectional study of 10,364 White and African Americans aged 48 to 73 years. Vital exhaustion scores were determined from the Maastricht questionnaire and categorized into quartiles. Retinopathy signs and retinal vascular caliber were graded from retinal photographs following standardized protocols. RESULTS:: After adjusting for age, gender, race, study center, education, smoking, blood pressure, diabetes, and other risk factors, higher vital exhaustion scores (highest versus lowest quartiles) were associated modestly with the presence of retinopathy (odds ratio [OR] = 1.27; 95% Confidence Interval [CI] = 1.01-1.59), particularly retinal hemorrhages (OR = 1.71; 95% CI = 1.20-2.44), and with generalized retinal venular widening (OR = 1.19; 95% CI = 1.03-1.38). Analyzing vital exhaustion as a continuous variable did not change the pattern of the associations. CONCLUSIONS:: Middle-aged people with vital exhaustion may be more likely to have retinopathy signs that have been identified as risk predictors of cardiovascular events. Further research is needed to explore the possible adverse effects of negative emotion on the microcirculation. Copyright © 2009 by the American Psychosomatic Society.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychosomaticmedicine.org/en_US
dc.relation.ispartofPsychosomatic Medicineen_US
dc.subject.meshAgeden_US
dc.subject.meshCommunity Health Services - Utilizationen_US
dc.subject.meshCoronary Artery Disease - Epidemiology - Physiopathologyen_US
dc.subject.meshDepression - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshFatigue - Epidemiology - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrocirculation - Physiologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetinal Diseases - Epidemiology - Physiopathologyen_US
dc.subject.meshRisk Factorsen_US
dc.titleVital exhaustion and retinal microvascular changes in cardiovascular disease: Atherosclerosis risk in communities studyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1097/PSY.0b013e318190f009en_US
dc.identifier.pmid19073748-
dc.identifier.pmcidPMC2987558-
dc.identifier.scopuseid_2-s2.0-68549117171en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68549117171&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume71en_US
dc.identifier.issue3en_US
dc.identifier.spage308en_US
dc.identifier.epage312en_US
dc.identifier.isiWOS:000265281800009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridRogers, S=12768398500en_US
dc.identifier.scopusauthoridMosley, TH=6603754517en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridCouper, D=7004067300en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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