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Article: Evidence of retinal vascular narrowing in glaucomatous eyes in an Asian population

TitleEvidence of retinal vascular narrowing in glaucomatous eyes in an Asian population
Authors
Issue Date2008
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2008, v. 49 n. 12, p. 5397-5402 How to Cite?
AbstractPURPOSE. To examine the relationship between retinal vascular caliber and glaucoma in an Asian population. METHODS. A population-based, cross-sectional study of 3019 persons of Asian Malay ethnicity aged 40 to 80 years residing in Singapore. All participants had dilated digital retinal photographs taken of both eyes. From these, retinal vascular caliber was measured with a computer-based technique according to a standardized protocol. Glaucoma was diagnosed based on the International Society of Geographic and Epidemiologic Ophthalmology classification and included people with glaucomatous optic neuropathy and compatible visual field loss. RESULTS. There were 127 (4.2%) participants with glaucoma. Mean retinal arteriolar and venular calibers were significantly narrower in persons with than in those without glaucoma (136.4 μm vs. 139.7 μm, P = 0.02 and 209.2 μm vs. 219.7 μm, P < 0.001, respectively). After adjusting for age, sex, smoking, IOP, and other vascular risk factors, persons with narrower retinal arteriolar and venular caliber were more likely to have glaucoma (odds ratio [OR], 1.29; 95% confidence interval [CI], 1.07-1.56 and OR, 1.49; 95% CI, 1.24-1.79, for each SD reduction in arteriolar and venular caliber, respectively) and a vertical cup-to-disc ratio ≥ 0.7 (OR, 1.35; 95% CI, 1.12-1.63 and OR, 1.65; 95% CI, 1.38-1.98, respectively). Retinal vascular caliber was not associated with intraocular pressure. CONCLUSIONS. These findings support an association of narrower retinal arteriolar and venular caliber changes with glaucomatous optic neuropathy, independent of intraocular pressure. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183562
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAmerasinghe, Nen_US
dc.contributor.authorAung, Ten_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorFong, CWen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorSaw, SMen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:46Z-
dc.date.available2013-05-28T06:14:46Z-
dc.date.issued2008en_US
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2008, v. 49 n. 12, p. 5397-5402en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/183562-
dc.description.abstractPURPOSE. To examine the relationship between retinal vascular caliber and glaucoma in an Asian population. METHODS. A population-based, cross-sectional study of 3019 persons of Asian Malay ethnicity aged 40 to 80 years residing in Singapore. All participants had dilated digital retinal photographs taken of both eyes. From these, retinal vascular caliber was measured with a computer-based technique according to a standardized protocol. Glaucoma was diagnosed based on the International Society of Geographic and Epidemiologic Ophthalmology classification and included people with glaucomatous optic neuropathy and compatible visual field loss. RESULTS. There were 127 (4.2%) participants with glaucoma. Mean retinal arteriolar and venular calibers were significantly narrower in persons with than in those without glaucoma (136.4 μm vs. 139.7 μm, P = 0.02 and 209.2 μm vs. 219.7 μm, P < 0.001, respectively). After adjusting for age, sex, smoking, IOP, and other vascular risk factors, persons with narrower retinal arteriolar and venular caliber were more likely to have glaucoma (odds ratio [OR], 1.29; 95% confidence interval [CI], 1.07-1.56 and OR, 1.49; 95% CI, 1.24-1.79, for each SD reduction in arteriolar and venular caliber, respectively) and a vertical cup-to-disc ratio ≥ 0.7 (OR, 1.35; 95% CI, 1.12-1.63 and OR, 1.65; 95% CI, 1.38-1.98, respectively). Retinal vascular caliber was not associated with intraocular pressure. CONCLUSIONS. These findings support an association of narrower retinal arteriolar and venular caliber changes with glaucomatous optic neuropathy, independent of intraocular pressure. Copyright © Association for Research in Vision and Ophthalmology.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshArterioles - Pathologyen_US
dc.subject.meshAsian Continental Ancestry Group - Ethnologyen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshConstriction, Pathologicen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlaucoma - Diagnosis - Ethnologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshIntraocular Pressureen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOptic Nerve Diseases - Diagnosis - Ethnologyen_US
dc.subject.meshPhotographyen_US
dc.subject.meshRetinal Vessels - Pathologyen_US
dc.subject.meshSingapore - Epidemiologyen_US
dc.subject.meshVenules - Pathologyen_US
dc.titleEvidence of retinal vascular narrowing in glaucomatous eyes in an Asian populationen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.08-2142en_US
dc.identifier.pmid18719076-
dc.identifier.scopuseid_2-s2.0-58149243055en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58149243055&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue12en_US
dc.identifier.spage5397en_US
dc.identifier.epage5402en_US
dc.identifier.isiWOS:000261193900031-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAmerasinghe, N=25121432000en_US
dc.identifier.scopusauthoridAung, T=26643141900en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridFong, CW=16309692300en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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