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Article: Evidence of arteriolar narrowing in low-birth-weight children

TitleEvidence of arteriolar narrowing in low-birth-weight children
Authors
Issue Date2008
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 2008, v. 118 n. 5, p. 518-524 How to Cite?
AbstractBackground - Cardiovascular disease may have its origins in utero, but the influence of in utero growth on microvascular structure in children is unknown. We hypothesized that poor in utero growth is associated with narrower arteriolar caliber, which may help explain the established association of low birth weight with hypertension and cardiovascular disease in adulthood. Methods and Results - We examined the relation of birth weight and other markers of in utero growth to microvascular caliber in the retina in a population-based study of 1369 6-year-old children in Sydney, Australia (Sydney Childhood Eye Study). Birth weight, birth length, and head circumference were obtained from parental records. Retinal arteriolar and venular calibers were measured from digitized retinal photographs by a validated computer-assisted method. Lower birth weight, shorter birth length, and smaller head circumference were associated with narrower retinal arteriolar caliber. Each kilogram decrease in birth weight was associated with a 2.3-μAm (95% CI 0.6 to 3.9, P=0.01) narrower retinal arteriolar caliber after controlling for age, gender, ethnicity, height, body mass index, axial length, mean arterial blood pressure, and prematurity. Similar associations were observed between shorter birth length and smaller head circumference with narrower retinal arteriolar caliber. Conclusions - Children who had lower birth weight, shorter birth length, and smaller head circumference had narrower retinal arteriolar calibers. These data support the concept that poor in utero growth may have an adverse influence on microvascular structure. © 2008 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/183553
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorLiew, Gen_US
dc.contributor.authorRochtchina, Een_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorRobaei, Den_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:39Z-
dc.date.available2013-05-28T06:14:39Z-
dc.date.issued2008en_US
dc.identifier.citationCirculation, 2008, v. 118 n. 5, p. 518-524en_US
dc.identifier.issn0009-7322en_US
dc.identifier.urihttp://hdl.handle.net/10722/183553-
dc.description.abstractBackground - Cardiovascular disease may have its origins in utero, but the influence of in utero growth on microvascular structure in children is unknown. We hypothesized that poor in utero growth is associated with narrower arteriolar caliber, which may help explain the established association of low birth weight with hypertension and cardiovascular disease in adulthood. Methods and Results - We examined the relation of birth weight and other markers of in utero growth to microvascular caliber in the retina in a population-based study of 1369 6-year-old children in Sydney, Australia (Sydney Childhood Eye Study). Birth weight, birth length, and head circumference were obtained from parental records. Retinal arteriolar and venular calibers were measured from digitized retinal photographs by a validated computer-assisted method. Lower birth weight, shorter birth length, and smaller head circumference were associated with narrower retinal arteriolar caliber. Each kilogram decrease in birth weight was associated with a 2.3-μAm (95% CI 0.6 to 3.9, P=0.01) narrower retinal arteriolar caliber after controlling for age, gender, ethnicity, height, body mass index, axial length, mean arterial blood pressure, and prematurity. Similar associations were observed between shorter birth length and smaller head circumference with narrower retinal arteriolar caliber. Conclusions - Children who had lower birth weight, shorter birth length, and smaller head circumference had narrower retinal arteriolar calibers. These data support the concept that poor in utero growth may have an adverse influence on microvascular structure. © 2008 American Heart Association, Inc.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.orgen_US
dc.relation.ispartofCirculationen_US
dc.subject.meshArterioles - Pathologyen_US
dc.subject.meshAustralia - Epidemiologyen_US
dc.subject.meshBody Heighten_US
dc.subject.meshCardiovascular Diseases - Epidemiology - Pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHead - Anatomy & Histologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Epidemiology - Pathologyen_US
dc.subject.meshInfant, Low Birth Weighten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRetinal Vessels - Pathologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshVenules - Pathologyen_US
dc.titleEvidence of arteriolar narrowing in low-birth-weight childrenen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1161/CIRCULATIONAHA.107.747329en_US
dc.identifier.pmid18625895-
dc.identifier.scopuseid_2-s2.0-49649119083en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-49649119083&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume118en_US
dc.identifier.issue5en_US
dc.identifier.spage518en_US
dc.identifier.epage524en_US
dc.identifier.isiWOS:000257994500009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridLiew, G=12796147900en_US
dc.identifier.scopusauthoridRochtchina, E=6701613193en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridRobaei, D=8642564000en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWong, TY=35231271400en_US

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