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Article: Retinal arteriolar caliber predicts incident retinopathy

TitleRetinal arteriolar caliber predicts incident retinopathy
Authors
Issue Date2008
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2008, v. 31 n. 4, p. 761-763 How to Cite?
AbstractChanges in retinal vascular caliber may reflect subclinical microvascular disease and provide prognostic information regarding risk of retinopathy. In this study, we examined the prospective association of retinal vascular caliber with retinopathy risk in an Australian population-based cohort. A total of 906 participants without retinopathy at baseline had retinal vascular caliber measured from photographs and were followed-up for 5 years for incident retinopathy. After adjusting for age, sex, systolic blood pressure, A1C, and other risk factors, individuals with wider retinal arteriolar caliber (widest 25% vs. the remaining three-quarters of the population) were more likely to develop incident retinopathy (odds ratio 4.79 [95% CI 1.57-14.58]). This association was not significant in individuals without diabetes. Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy. © 2008 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/183551
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRogers, SLen_US
dc.contributor.authorTikellis, Gen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorTapp, Ren_US
dc.contributor.authorShaw, Jen_US
dc.contributor.authorZimmet, PZen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:38Z-
dc.date.available2013-05-28T06:14:38Z-
dc.date.issued2008en_US
dc.identifier.citationDiabetes Care, 2008, v. 31 n. 4, p. 761-763en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://hdl.handle.net/10722/183551-
dc.description.abstractChanges in retinal vascular caliber may reflect subclinical microvascular disease and provide prognostic information regarding risk of retinopathy. In this study, we examined the prospective association of retinal vascular caliber with retinopathy risk in an Australian population-based cohort. A total of 906 participants without retinopathy at baseline had retinal vascular caliber measured from photographs and were followed-up for 5 years for incident retinopathy. After adjusting for age, sex, systolic blood pressure, A1C, and other risk factors, individuals with wider retinal arteriolar caliber (widest 25% vs. the remaining three-quarters of the population) were more likely to develop incident retinopathy (odds ratio 4.79 [95% CI 1.57-14.58]). This association was not significant in individuals without diabetes. Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy. © 2008 by the American Diabetes Association.en_US
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_US
dc.relation.ispartofDiabetes Careen_US
dc.subject.meshArterioles - Anatomy & Histologyen_US
dc.subject.meshAustraliaen_US
dc.subject.meshBlood Glucose - Metabolismen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshDiabetic Retinopathy - Epidemiology - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshRetinal Artery - Physiopathologyen_US
dc.titleRetinal arteriolar caliber predicts incident retinopathyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2337/dc07-1622en_US
dc.identifier.pmid18184895-
dc.identifier.scopuseid_2-s2.0-48649102056en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48649102056&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue4en_US
dc.identifier.spage761en_US
dc.identifier.epage763en_US
dc.identifier.isiWOS:000254591900026-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRogers, SL=12768398500en_US
dc.identifier.scopusauthoridTikellis, G=6602765289en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridTapp, R=7004191809en_US
dc.identifier.scopusauthoridShaw, J=7102179242en_US
dc.identifier.scopusauthoridZimmet, PZ=7102179242en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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