File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Relationships of retinal vessel diameters with optic disc, macular and retinal nerve fiber layer parameters in 6-year-old children

TitleRelationships of retinal vessel diameters with optic disc, macular and retinal nerve fiber layer parameters in 6-year-old children
Authors
Issue Date2008
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2008, v. 49 n. 6, p. 2403-2408 How to Cite?
AbstractPURPOSE. To describe the normal anatomic relationships of retinal vessel diameters with optic disc, macula, and retinal nerve fiber layer parameters in young children. METHODS. This was a population-based, cross-sectional study of 1204 healthy children 6 years of age who were participating in the Sydney Childhood Eye Study. Retinal arteriolar and venular diameters were measured from fundus photographs using standardized computer-based methods. Optical coherence tomography was performed to obtain measurements of the optic disc, macula, and retinal nerve fiber layer parameters. RESULTS. In multivariate analyses, each standard deviation (SD) decrease in optic disc area was associated with a 0.14-pixel decrease (P = 0.05) in arteriolar diameter and a 0.31-pixel decrease (P < 0.01) in venular diameter. Each SD decrease in optic cup area was associated with a 0.15-pixel decrease (P = 0.05) in arteriolar diameter and a 0.43-pixel decrease (P < 0.01) in venular diameter. Each SD decrease in macular (inner/outer) thickness or volume was associated with a 0.25- to 0.39-pixel decrease (P < 0.01) in arteriolar diameter and a 0.36-to 0.71-pixel decrease (P < 0.01) in venular diameter, and each SD decrease in retinal nerve fiber layer thickness was associated with a 0.62-pixel decrease (P < 0.01) in arteriolar diameter and a 0.99-pixel decrease (P < 0.01) in venular diameter. CONCLUSIONS. Children's eyes with a smaller optic disc, thinner macula, and thinner retinal nerve fiber layer have narrower retinal vessels. These anatomic relationships may provide new insights into the vascular etiology of various ocular diseases. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183548
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorHuynh, Sen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorTaylor, Ben_US
dc.contributor.authorIslam, FMAen_US
dc.contributor.authorSaw, SMen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorMitchell, Pen_US
dc.date.accessioned2013-05-28T06:14:36Z-
dc.date.available2013-05-28T06:14:36Z-
dc.date.issued2008en_US
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2008, v. 49 n. 6, p. 2403-2408en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/183548-
dc.description.abstractPURPOSE. To describe the normal anatomic relationships of retinal vessel diameters with optic disc, macula, and retinal nerve fiber layer parameters in young children. METHODS. This was a population-based, cross-sectional study of 1204 healthy children 6 years of age who were participating in the Sydney Childhood Eye Study. Retinal arteriolar and venular diameters were measured from fundus photographs using standardized computer-based methods. Optical coherence tomography was performed to obtain measurements of the optic disc, macula, and retinal nerve fiber layer parameters. RESULTS. In multivariate analyses, each standard deviation (SD) decrease in optic disc area was associated with a 0.14-pixel decrease (P = 0.05) in arteriolar diameter and a 0.31-pixel decrease (P < 0.01) in venular diameter. Each SD decrease in optic cup area was associated with a 0.15-pixel decrease (P = 0.05) in arteriolar diameter and a 0.43-pixel decrease (P < 0.01) in venular diameter. Each SD decrease in macular (inner/outer) thickness or volume was associated with a 0.25- to 0.39-pixel decrease (P < 0.01) in arteriolar diameter and a 0.36-to 0.71-pixel decrease (P < 0.01) in venular diameter, and each SD decrease in retinal nerve fiber layer thickness was associated with a 0.62-pixel decrease (P < 0.01) in arteriolar diameter and a 0.99-pixel decrease (P < 0.01) in venular diameter. CONCLUSIONS. Children's eyes with a smaller optic disc, thinner macula, and thinner retinal nerve fiber layer have narrower retinal vessels. These anatomic relationships may provide new insights into the vascular etiology of various ocular diseases. Copyright © Association for Research in Vision and Ophthalmology.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.subject.meshArterioles - Anatomy & Histologyen_US
dc.subject.meshChilden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMacula Lutea - Cytologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve Fibersen_US
dc.subject.meshOptic Disk - Anatomy & Histologyen_US
dc.subject.meshPhotographyen_US
dc.subject.meshRetinal Ganglion Cells - Cytologyen_US
dc.subject.meshRetinal Vessels - Anatomy & Histologyen_US
dc.subject.meshTomography, Optical Coherenceen_US
dc.subject.meshVenules - Anatomy & Histologyen_US
dc.titleRelationships of retinal vessel diameters with optic disc, macular and retinal nerve fiber layer parameters in 6-year-old childrenen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.07-1313en_US
dc.identifier.pmid18281614-
dc.identifier.scopuseid_2-s2.0-47249105952en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47249105952&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue6en_US
dc.identifier.spage2403en_US
dc.identifier.epage2408en_US
dc.identifier.isiWOS:000256306800015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridHuynh, S=8586835800en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridTaylor, B=14047527900en_US
dc.identifier.scopusauthoridIslam, FMA=35446440500en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US
dc.identifier.scopusauthoridWong, TY=35231271400en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats