File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Relation of retinopathy to coronary artery calcification: The multi-ethnic study of atherosclerosis

TitleRelation of retinopathy to coronary artery calcification: The multi-ethnic study of atherosclerosis
Authors
Issue Date2008
PublisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/
Citation
American Journal Of Epidemiology, 2008, v. 167 n. 1, p. 51-58 How to Cite?
AbstractMicrovascular disease, reflected by retinal vascular changes, has been shown to predict clinical coronary heart disease. Whether retinal vascular changes are associated with subclinical coronary artery disease is unclear and was examined in this study. The authors conducted a multiethnic, population-based study of 6,147 persons aged 45-84 years, sampled from six US communities in 2002-2004, who were free of clinical cardiovascular disease. Coronary artery calcification (CAC), a noninvasive measure of subclinical coronary artery disease, was assessed by cardiac computed tomography scanning and categorized into three groups of increasing severity: none (average CAC score = 0), mild (1-100), and moderate-to-severe (>100). Retinopathy signs and retinal vascular caliber were graded from retinal photographs following standardized protocols. After adjustment for age, gender, race/ethnicity, blood pressure, diabetes, lipid profile, smoking, and other risk factors, retinopathy was associated with having a moderate-to-severe CAC score (odds ratio = 1.43, 95% confidence interval: 1.18, 1.75). This association remained significant in both men and women and in persons with and without diabetes or hypertension. Variations in retinal vascular caliber were not significantly associated with CAC score. This study shows that retinopathy signs are independently associated with CAC, supporting the concept that common pathophysiologic processes may underlie both micro- and macrovascular disease. © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/183535
ISSN
2015 Impact Factor: 5.036
2015 SCImago Journal Rankings: 3.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, TYen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorIslam, FMAen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorCriqui, MHen_US
dc.contributor.authorCotch, MFen_US
dc.contributor.authorCarr, JJen_US
dc.contributor.authorKlein, BEKen_US
dc.contributor.authorSharrett, ARen_US
dc.date.accessioned2013-05-28T06:14:30Z-
dc.date.available2013-05-28T06:14:30Z-
dc.date.issued2008en_US
dc.identifier.citationAmerican Journal Of Epidemiology, 2008, v. 167 n. 1, p. 51-58en_US
dc.identifier.issn0002-9262en_US
dc.identifier.urihttp://hdl.handle.net/10722/183535-
dc.description.abstractMicrovascular disease, reflected by retinal vascular changes, has been shown to predict clinical coronary heart disease. Whether retinal vascular changes are associated with subclinical coronary artery disease is unclear and was examined in this study. The authors conducted a multiethnic, population-based study of 6,147 persons aged 45-84 years, sampled from six US communities in 2002-2004, who were free of clinical cardiovascular disease. Coronary artery calcification (CAC), a noninvasive measure of subclinical coronary artery disease, was assessed by cardiac computed tomography scanning and categorized into three groups of increasing severity: none (average CAC score = 0), mild (1-100), and moderate-to-severe (>100). Retinopathy signs and retinal vascular caliber were graded from retinal photographs following standardized protocols. After adjustment for age, gender, race/ethnicity, blood pressure, diabetes, lipid profile, smoking, and other risk factors, retinopathy was associated with having a moderate-to-severe CAC score (odds ratio = 1.43, 95% confidence interval: 1.18, 1.75). This association remained significant in both men and women and in persons with and without diabetes or hypertension. Variations in retinal vascular caliber were not significantly associated with CAC score. This study shows that retinopathy signs are independently associated with CAC, supporting the concept that common pathophysiologic processes may underlie both micro- and macrovascular disease. © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/en_US
dc.relation.ispartofAmerican Journal of Epidemiologyen_US
dc.subject.meshAfrican Americansen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAsian Americansen_US
dc.subject.meshCalcinosis - Complications - Ethnology - Radiographyen_US
dc.subject.meshCoronary Disease - Complications - Ethnology - Radiographyen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHispanic Americansen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRetina - Pathologyen_US
dc.subject.meshRetinal Diseases - Complications - Diagnosis - Ethnologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshUnited Statesen_US
dc.titleRelation of retinopathy to coronary artery calcification: The multi-ethnic study of atherosclerosisen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1093/aje/kwm256en_US
dc.identifier.pmid17893402-
dc.identifier.scopuseid_2-s2.0-37549014820en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37549014820&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume167en_US
dc.identifier.issue1en_US
dc.identifier.spage51en_US
dc.identifier.epage58en_US
dc.identifier.isiWOS:000251864100009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridIslam, FMA=55399085000en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridCriqui, MH=7005209601en_US
dc.identifier.scopusauthoridCotch, MF=6603036992en_US
dc.identifier.scopusauthoridCarr, JJ=35420088500en_US
dc.identifier.scopusauthoridKlein, BEK=35433541400en_US
dc.identifier.scopusauthoridSharrett, AR=7006662570en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats