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Article: Is aspirin intake associated with early age-related macular degeneration? The Singapore Indian Eye Study

TitleIs aspirin intake associated with early age-related macular degeneration? The Singapore Indian Eye Study
Authors
Issue Date2013
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2013, v. 97 n. 6, p. 785-788 How to Cite?
AbstractBackground/aims: To examine the relationship between aspirin intake and early age-related macular degeneration (AMD) among an Asian population. Methods: A population based cross sectional study of 3207 ethnic Indians aged 40 years or older residing in Singapore. AMD signs were graded from retinal images following the modified Wisconsin grading system. Information on aspirin intake was obtained from a standardised questionnaire. Results: The prevalence of early AMD was 5.6%. Aspirin use was reported by 11.4% of participants. Early AMD signs were present among 10.9% of aspirin users and 4.9% of non-aspirin users (p<0.001). After adjusting for potential confounders, including age, smoking and previous cataract surgery, aspirin use was associated with early AMD (OR 1.50; 95% CI: 1.01 to 2.22). The association weakened and was not significant after additional adjustment for cardiovascular disease (OR 1.38; 95% CI 0.89 to 2.14). In stratified analysis, aspirin use was significantly associated with early AMD in participants with (adjusted OR 2.64, 95% CI 1.31 to 5.36) but not without (OR 0.73; 95% CI 0.36 to 1.51) a history of cardiovascular disease (interaction term, p=0.011). Conclusions: Aspirin intake overall was not associated with early AMD in this sample of Asian Indians, but in those with a history of cardiovascular disease the association between aspirin intake and early AMD might warrant further investigation. © 2013 by the BMJ Publishing Group Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/183416
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorTay, WTen_US
dc.contributor.authorCheung, GCMen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-27T07:13:27Z-
dc.date.available2013-05-27T07:13:27Z-
dc.date.issued2013en_US
dc.identifier.citationBritish Journal Of Ophthalmology, 2013, v. 97 n. 6, p. 785-788en_US
dc.identifier.issn0007-1161en_US
dc.identifier.urihttp://hdl.handle.net/10722/183416-
dc.description.abstractBackground/aims: To examine the relationship between aspirin intake and early age-related macular degeneration (AMD) among an Asian population. Methods: A population based cross sectional study of 3207 ethnic Indians aged 40 years or older residing in Singapore. AMD signs were graded from retinal images following the modified Wisconsin grading system. Information on aspirin intake was obtained from a standardised questionnaire. Results: The prevalence of early AMD was 5.6%. Aspirin use was reported by 11.4% of participants. Early AMD signs were present among 10.9% of aspirin users and 4.9% of non-aspirin users (p<0.001). After adjusting for potential confounders, including age, smoking and previous cataract surgery, aspirin use was associated with early AMD (OR 1.50; 95% CI: 1.01 to 2.22). The association weakened and was not significant after additional adjustment for cardiovascular disease (OR 1.38; 95% CI 0.89 to 2.14). In stratified analysis, aspirin use was significantly associated with early AMD in participants with (adjusted OR 2.64, 95% CI 1.31 to 5.36) but not without (OR 0.73; 95% CI 0.36 to 1.51) a history of cardiovascular disease (interaction term, p=0.011). Conclusions: Aspirin intake overall was not associated with early AMD in this sample of Asian Indians, but in those with a history of cardiovascular disease the association between aspirin intake and early AMD might warrant further investigation. © 2013 by the BMJ Publishing Group Ltd.en_US
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_US
dc.relation.ispartofBritish Journal of Ophthalmologyen_US
dc.titleIs aspirin intake associated with early age-related macular degeneration? The Singapore Indian Eye Studyen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/bjophthalmol-2012-302253en_US
dc.identifier.pmid23486919-
dc.identifier.scopuseid_2-s2.0-84878016321en_US
dc.identifier.isiWOS:000319271300024-
dc.publisher.placeUnited Kingdomen_US

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