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Article: Phosphorylation and Recruitment of BAF60c in Chromatin Remodeling for Lipogenesis in Response to Insulin

TitlePhosphorylation and Recruitment of BAF60c in Chromatin Remodeling for Lipogenesis in Response to Insulin
Authors
Issue Date2013
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/molcel
Citation
Molecular Cell, 2013, v. 49 n. 2, p. 283-297 How to Cite?
AbstractFatty acid and triglyceride synthesis is induced in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of lipogenic enzymes, including fatty acid synthase and glycerol-3-phosphate acyltransferase. We recently reported the importance of USF-1 phosphorylation and subsequent acetylation in insulin-induced lipogenic gene activation. Here, we show that Brg1/Brm-associated factor (BAF) 60c is a specific chromatin remodeling component for lipogenic gene transcription in liver. In response to insulin, BAF60c is phosphorylated at S247 by atypical PKCζ/λ, which causes translocation of BAF60c to the nucleus and allows a direct interaction of BAF60c with USF-1 that is phosphorylated by DNA-PK and acetylated by P/CAF. Thus, BAF60c is recruited to form the lipoBAF complex to remodel chromatin structure and to activate lipogenic genes. Consequently, BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin. © 2013 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/183383
ISSN
2015 Impact Factor: 13.958
2015 SCImago Journal Rankings: 13.658
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_US
dc.contributor.authorWong, RHFen_US
dc.contributor.authorTang, Ten_US
dc.contributor.authorHudak, CSen_US
dc.contributor.authorYang, Den_US
dc.contributor.authorDuncan, REen_US
dc.contributor.authorSul, HSen_US
dc.date.accessioned2013-05-27T07:11:40Z-
dc.date.available2013-05-27T07:11:40Z-
dc.date.issued2013en_US
dc.identifier.citationMolecular Cell, 2013, v. 49 n. 2, p. 283-297en_US
dc.identifier.issn1097-2765en_US
dc.identifier.urihttp://hdl.handle.net/10722/183383-
dc.description.abstractFatty acid and triglyceride synthesis is induced in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of lipogenic enzymes, including fatty acid synthase and glycerol-3-phosphate acyltransferase. We recently reported the importance of USF-1 phosphorylation and subsequent acetylation in insulin-induced lipogenic gene activation. Here, we show that Brg1/Brm-associated factor (BAF) 60c is a specific chromatin remodeling component for lipogenic gene transcription in liver. In response to insulin, BAF60c is phosphorylated at S247 by atypical PKCζ/λ, which causes translocation of BAF60c to the nucleus and allows a direct interaction of BAF60c with USF-1 that is phosphorylated by DNA-PK and acetylated by P/CAF. Thus, BAF60c is recruited to form the lipoBAF complex to remodel chromatin structure and to activate lipogenic genes. Consequently, BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin. © 2013 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/molcelen_US
dc.relation.ispartofMolecular Cellen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Nucleus - Metabolismen_US
dc.subject.meshChromatin Assembly And Disassemblyen_US
dc.subject.meshEnergy Metabolismen_US
dc.subject.meshFatty Acid Synthetase Complex - Genetics - Metabolismen_US
dc.subject.meshHep G2 Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin - Physiologyen_US
dc.subject.meshLipogenesisen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Sciden_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshProtein Kinase C - Metabolismen_US
dc.subject.meshProtein Processing, Post-Translationalen_US
dc.subject.meshProtein Subunits - Metabolismen_US
dc.subject.meshProtein Transporten_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTranscription Factors - Metabolismen_US
dc.subject.meshTranscriptional Activationen_US
dc.subject.meshUpstream Stimulatory Factors - Metabolismen_US
dc.titlePhosphorylation and Recruitment of BAF60c in Chromatin Remodeling for Lipogenesis in Response to Insulinen_US
dc.typeArticleen_US
dc.identifier.emailWong, RHF: rogerwg@hku.hken_US
dc.identifier.authorityWong, RHF=rp01754en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.molcel.2012.10.028en_US
dc.identifier.pmid23219531-
dc.identifier.scopuseid_2-s2.0-84872798187en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84872798187&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue2en_US
dc.identifier.spage283en_US
dc.identifier.epage297en_US
dc.identifier.isiWOS:000314379400011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, Y=8054759100en_US
dc.identifier.scopusauthoridWong, RHF=16231857500en_US
dc.identifier.scopusauthoridTang, T=36464424800en_US
dc.identifier.scopusauthoridHudak, CS=24597252000en_US
dc.identifier.scopusauthoridYang, D=55507913200en_US
dc.identifier.scopusauthoridDuncan, RE=7401604707en_US
dc.identifier.scopusauthoridSul, HS=55664145900en_US

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