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Conference Paper: The regulation of HPA activity and anti-aging effect of Qigong exercise for patients with chronic fatigue syndrome: telomerase activity and salivary cortisol

TitleThe regulation of HPA activity and anti-aging effect of Qigong exercise for patients with chronic fatigue syndrome: telomerase activity and salivary cortisol
Authors
KeywordsMedical sciences
Issue Date2013
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/medicine/journal/12160
Citation
The 34th Annual Meeting & Scientific Sessions of the Society of Behavioral Medicine (SBM 2013), San Francisco, CA., 20-23 March 2013. In Annals of Behavioral Medicine, 2013, v. 45 n. 2 suppl., p. S307, abstract D-213 How to Cite?
AbstractBACKGROUND: Our previous RCT showed that Qigong exercise has effects of reducing fatigue level, improving quality of life, and also anti-aging effect on CFS patients. Objectives In this RCT, the effects of Qigong exercise on fatigue as well as the relationships between fatigue and two biomarkers - telomerase activity and salivary cortisol level which designated theHPA axis activity were investigated. METHODS: A RCT was conducted. 16 sessions of Qigong was delivered. The primary outcome was change of Chalder’s fatigue scale. The telomerase activity in blood sample and salivary cortisol level at 5 time points in same day: awakening, 45 min after awakening, 12 pm, 5 pm and 9 pm ere collected. The mean of natural log of cortisol level (MNLSCL) and area under curve (AUC) for 5 time points were calculated. The primary outcome and differences of biomarkers (T1-T0) between Qigong and control groups were compared using T-test. The correlations between fatigue level and biomarkers were also assessed. RESULTS: The changes of Chalder’s fatigue (T1-T0) were −11.8 (11.4) and −4.1(6.5) for Qigong and control groups respectively (p<.001). The changes of MNLSCL were −0.405 (0.987) and −0.018 (0.595) (p=0.004), as well as −203.48 (444.03) and −13.49 (96.91) (p=.001) respectively in the changes of AUC (T1-T0). The differences of telomerase activity were 0.038 (0.203) and −0.105 (0.165) for Qigong and control groups respectively (p<.001). The correlations between change of fatigue with that of MNLSCL was 0.294 (p<.001), and with that of AUC was 0.387 (p<.001). CONCLUSION: Qigong may reduce fatigue level and HPA axis activity and increase telomerase activity. Improvement in fatigue may possibly relate to the changes in HPA activity while the mechanism of changes in telomerase activity needs further investigation.
DescriptionTheme: Technology: the Excitement and the Evidence
Poster Session D
Persistent Identifierhttp://hdl.handle.net/10722/183226
ISSN
2015 Impact Factor: 4.195
2015 SCImago Journal Rankings: 2.112

 

DC FieldValueLanguage
dc.contributor.authorHo, RTHen_US
dc.contributor.authorChan, JSMen_US
dc.contributor.authorNg, SMen_US
dc.contributor.authorLau, BWMen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorCheung, IKMen_US
dc.contributor.authorNg, BFLen_US
dc.contributor.authorZiea, ETCen_US
dc.contributor.authorChan, CLWen_US
dc.date.accessioned2013-05-15T01:48:35Z-
dc.date.available2013-05-15T01:48:35Z-
dc.date.issued2013en_US
dc.identifier.citationThe 34th Annual Meeting & Scientific Sessions of the Society of Behavioral Medicine (SBM 2013), San Francisco, CA., 20-23 March 2013. In Annals of Behavioral Medicine, 2013, v. 45 n. 2 suppl., p. S307, abstract D-213en_US
dc.identifier.issn0883-6612-
dc.identifier.urihttp://hdl.handle.net/10722/183226-
dc.descriptionTheme: Technology: the Excitement and the Evidence-
dc.descriptionPoster Session D-
dc.description.abstractBACKGROUND: Our previous RCT showed that Qigong exercise has effects of reducing fatigue level, improving quality of life, and also anti-aging effect on CFS patients. Objectives In this RCT, the effects of Qigong exercise on fatigue as well as the relationships between fatigue and two biomarkers - telomerase activity and salivary cortisol level which designated theHPA axis activity were investigated. METHODS: A RCT was conducted. 16 sessions of Qigong was delivered. The primary outcome was change of Chalder’s fatigue scale. The telomerase activity in blood sample and salivary cortisol level at 5 time points in same day: awakening, 45 min after awakening, 12 pm, 5 pm and 9 pm ere collected. The mean of natural log of cortisol level (MNLSCL) and area under curve (AUC) for 5 time points were calculated. The primary outcome and differences of biomarkers (T1-T0) between Qigong and control groups were compared using T-test. The correlations between fatigue level and biomarkers were also assessed. RESULTS: The changes of Chalder’s fatigue (T1-T0) were −11.8 (11.4) and −4.1(6.5) for Qigong and control groups respectively (p<.001). The changes of MNLSCL were −0.405 (0.987) and −0.018 (0.595) (p=0.004), as well as −203.48 (444.03) and −13.49 (96.91) (p=.001) respectively in the changes of AUC (T1-T0). The differences of telomerase activity were 0.038 (0.203) and −0.105 (0.165) for Qigong and control groups respectively (p<.001). The correlations between change of fatigue with that of MNLSCL was 0.294 (p<.001), and with that of AUC was 0.387 (p<.001). CONCLUSION: Qigong may reduce fatigue level and HPA axis activity and increase telomerase activity. Improvement in fatigue may possibly relate to the changes in HPA activity while the mechanism of changes in telomerase activity needs further investigation.-
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/medicine/journal/12160-
dc.relation.ispartofAnnals of Behavioral Medicineen_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectMedical sciences-
dc.titleThe regulation of HPA activity and anti-aging effect of Qigong exercise for patients with chronic fatigue syndrome: telomerase activity and salivary cortisolen_US
dc.typeConference_Paperen_US
dc.identifier.emailHo, RTH: tinho@hku.hken_US
dc.identifier.emailChan, JSM: chansm5@hkucc.hku.hken_US
dc.identifier.emailNg, SM: ngsiuman@hku.hken_US
dc.identifier.emailLau, BWM: bwmlau@hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.emailCheung, IKM: irenech@hkucc.hku.hken_US
dc.identifier.emailChan, CLW: cecichan@hku.hken_US
dc.identifier.authorityHo, RTH=rp00497en_US
dc.identifier.authorityNg, SM=rp00611en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityChan, CLW=rp00579en_US
dc.identifier.hkuros214089en_US
dc.identifier.hkuros214090-
dc.identifier.hkuros226658-
dc.identifier.volume45-
dc.identifier.issue2 suppl.-
dc.identifier.spageS307-
dc.identifier.epageS307-
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 130605-

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