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Conference Paper: Tooth Loss and Vascular Cognitive Impairment in Acute Stroke Patients

TitleTooth Loss and Vascular Cognitive Impairment in Acute Stroke Patients
Authors
KeywordsBlood
Cognitive Impairment
Periodontal disease and Teeth
Issue Date2013
PublisherSage Publications, Inc. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
The 91st General Session & Exhibition of the International Association for Dental Research (IADR), Seattle, Washington, USA, 20-23 March 2013. In Journal of Dental Research, 2013, v. 92 n. Special Issue A: abstract no. 88 How to Cite?
AbstractObjective: Recent studies show that tooth loss may be associated with cognitive impairment and dementia. Vascular cognitive impairment is a common consequence of ischemic stroke. This cross-sectional study investigated the association of tooth loss with vascular cognitive impairment in patients with acute stroke. Method: 161 subjects with acute ischemic stroke were recruited from a group of 1,298 patients who were admitted to a Stroke Unit at the affiliated Yuebei People's Hospital of Shantou University Medical College. After admission, medical fasting blood tests were undertaken within 24 hours and the number of teeth present was recorded within seven days. Cognitive impairment was evaluated with the Chinese version of Montreal Cognitive Assessment (MoCA) within three days. Result: A receiver-operating characteristic curve showed that the ideal cut-point of tooth loss that could maximize its association with vascular cognitive impairment was 7 that generated the sensitivity and specificity of 61.2% and 73.2%, respectively. The patients who lost 8 to 28 teeth exhibited lower MoCA values as compared to those with loss of ≤ 7 teeth (13.2±6.6 vs. 17.3±6.0, p<0.001). Logistic regression analysis showed that loss of 8-28 teeth (OR=6.5, 95% CI: 2.2-18.9, p=0.001), low-density lipoprotein, diabetes, stroke history and income were significantly related with vascular cognitive impairment (MoCA<20.0). Conclusion: The present study suggests that multiple tooth loss (≥ 8 teeth) may be a risk factor of vascular cognitive impairment in patients with acute ischemic stroke. Further longitudinal study is warranted to support the current findings and elaborate the clinical implications. Supported in part by the Modern Dental Laboratory/HKU Endowment Fund to LJJ. This abstract is based on research that was funded entirely or partially by an outside source: Supported in part by the Modern Dental Laboratory/HKU Endowment Fund to LJJ
DescriptionOral Presentation
Session 20: Epidemiology - Oral & Systemic Disease
Persistent Identifierhttp://hdl.handle.net/10722/183207
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorZhu, Jen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorZhu, Fen_US
dc.contributor.authorZhang, Cen_US
dc.contributor.authorMcGrath, CPJen_US
dc.contributor.authorJin, Len_US
dc.date.accessioned2013-05-15T01:48:15Z-
dc.date.available2013-05-15T01:48:15Z-
dc.date.issued2013en_US
dc.identifier.citationThe 91st General Session & Exhibition of the International Association for Dental Research (IADR), Seattle, Washington, USA, 20-23 March 2013. In Journal of Dental Research, 2013, v. 92 n. Special Issue A: abstract no. 88en_US
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/183207-
dc.descriptionOral Presentation-
dc.descriptionSession 20: Epidemiology - Oral & Systemic Disease-
dc.description.abstractObjective: Recent studies show that tooth loss may be associated with cognitive impairment and dementia. Vascular cognitive impairment is a common consequence of ischemic stroke. This cross-sectional study investigated the association of tooth loss with vascular cognitive impairment in patients with acute stroke. Method: 161 subjects with acute ischemic stroke were recruited from a group of 1,298 patients who were admitted to a Stroke Unit at the affiliated Yuebei People's Hospital of Shantou University Medical College. After admission, medical fasting blood tests were undertaken within 24 hours and the number of teeth present was recorded within seven days. Cognitive impairment was evaluated with the Chinese version of Montreal Cognitive Assessment (MoCA) within three days. Result: A receiver-operating characteristic curve showed that the ideal cut-point of tooth loss that could maximize its association with vascular cognitive impairment was 7 that generated the sensitivity and specificity of 61.2% and 73.2%, respectively. The patients who lost 8 to 28 teeth exhibited lower MoCA values as compared to those with loss of ≤ 7 teeth (13.2±6.6 vs. 17.3±6.0, p<0.001). Logistic regression analysis showed that loss of 8-28 teeth (OR=6.5, 95% CI: 2.2-18.9, p=0.001), low-density lipoprotein, diabetes, stroke history and income were significantly related with vascular cognitive impairment (MoCA<20.0). Conclusion: The present study suggests that multiple tooth loss (≥ 8 teeth) may be a risk factor of vascular cognitive impairment in patients with acute ischemic stroke. Further longitudinal study is warranted to support the current findings and elaborate the clinical implications. Supported in part by the Modern Dental Laboratory/HKU Endowment Fund to LJJ. This abstract is based on research that was funded entirely or partially by an outside source: Supported in part by the Modern Dental Laboratory/HKU Endowment Fund to LJJ-
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925-
dc.relation.ispartofJournal of Dental Researchen_US
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc.-
dc.subjectBlood-
dc.subjectCognitive Impairment-
dc.subjectPeriodontal disease and Teeth-
dc.titleTooth Loss and Vascular Cognitive Impairment in Acute Stroke Patientsen_US
dc.typeConference_Paperen_US
dc.identifier.emailZhang, C: zhangcf@hku.hken_US
dc.identifier.emailMcGrath, CPJ: mcgrathc@hkucc.hku.hken_US
dc.identifier.emailJin, L: ljjin@hkucc.hku.hken_US
dc.identifier.authorityZhang, C=rp01408en_US
dc.identifier.authorityMcGrath, CPJ=rp00037en_US
dc.identifier.authorityJin, L=rp00028en_US
dc.identifier.hkuros214384en_US
dc.identifier.volume92en_US
dc.identifier.issueSpecial Issue A: abstract no. 88en_US
dc.publisher.placeUnited States-

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