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Article: Recent advances in the herbal treatment of non-alcoholic fatty liver disease

TitleRecent advances in the herbal treatment of non-alcoholic fatty liver disease
Authors
KeywordsGarlic-derived monomers
Herbal treatment
Milk thistle-derived substances
Non-alcoholic fatty liver disease
Pathogenesis
Issue Date2013
PublisherCommittee on Chinese Medicine and Pharmacy. The Journal's web site is located at http://www.jtcm.org/backissues.asp
Citation
Journal of Traditional and Complementary Medicine, 2013, v. 3 n. 2, p. 88-94 How to Cite?
AbstractNon-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver injury across the world. It is also strongly related to other pathological conditions, including obesity, diabetes, cardiovascular diseases, and symptoms of metabolic syndrome. Pathogenesis of NAFLD remains not fully characterized but is generally attributed to the occurrence of insulin resistance, lipid metabolism dysfunction,0 oxidative stress, inflammation, and necro-apoptosis. Every potential therapeutic strategy should target one or some of these pathological events in the liver. Over the past decades, application of herbal treatment for NAFLD has received increasing attention due to its wide availability, low side effects, and proven therapeutic mechanisms and benefits. In recent years, some monomers and certain functional mixtures of herbs have been extensively examined for their potential uses in NAFLD treatment. In the present review, we selected several herbal derivatives under intense basic and/or clinical investigations by carrying out a PubMed search of English language articles relevant to herbal derivatives and NAFLD, such as polysaccharide portion of wolfberry, garlic-derived monomers, red grape-derived resveratrol, and milk thistle-derived substances. They have been shown to target the pathological events during NAFLD initiation and progression both in pre-clinical studies and clinical trials. Although more detailed mechanistic researches and long-term clinical evaluations are needed for their future applications, they offer unanticipated and great health benefits without obvious adverse effects in NAFLD therapy.
Persistent Identifierhttp://hdl.handle.net/10722/183091
ISSN
2015 SCImago Journal Rankings: 0.486

 

DC FieldValueLanguage
dc.contributor.authorXiao, Jen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorLiong, ECen_US
dc.contributor.authorTipoe, GLen_US
dc.date.accessioned2013-05-15T01:41:35Z-
dc.date.available2013-05-15T01:41:35Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Traditional and Complementary Medicine, 2013, v. 3 n. 2, p. 88-94en_US
dc.identifier.issn2225-4110-
dc.identifier.urihttp://hdl.handle.net/10722/183091-
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver injury across the world. It is also strongly related to other pathological conditions, including obesity, diabetes, cardiovascular diseases, and symptoms of metabolic syndrome. Pathogenesis of NAFLD remains not fully characterized but is generally attributed to the occurrence of insulin resistance, lipid metabolism dysfunction,0 oxidative stress, inflammation, and necro-apoptosis. Every potential therapeutic strategy should target one or some of these pathological events in the liver. Over the past decades, application of herbal treatment for NAFLD has received increasing attention due to its wide availability, low side effects, and proven therapeutic mechanisms and benefits. In recent years, some monomers and certain functional mixtures of herbs have been extensively examined for their potential uses in NAFLD treatment. In the present review, we selected several herbal derivatives under intense basic and/or clinical investigations by carrying out a PubMed search of English language articles relevant to herbal derivatives and NAFLD, such as polysaccharide portion of wolfberry, garlic-derived monomers, red grape-derived resveratrol, and milk thistle-derived substances. They have been shown to target the pathological events during NAFLD initiation and progression both in pre-clinical studies and clinical trials. Although more detailed mechanistic researches and long-term clinical evaluations are needed for their future applications, they offer unanticipated and great health benefits without obvious adverse effects in NAFLD therapy.-
dc.languageengen_US
dc.publisherCommittee on Chinese Medicine and Pharmacy. The Journal's web site is located at http://www.jtcm.org/backissues.asp-
dc.relation.ispartofJournal of Traditional and Complementary Medicineen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectGarlic-derived monomers-
dc.subjectHerbal treatment-
dc.subjectMilk thistle-derived substances-
dc.subjectNon-alcoholic fatty liver disease-
dc.subjectPathogenesis-
dc.titleRecent advances in the herbal treatment of non-alcoholic fatty liver diseaseen_US
dc.typeArticleen_US
dc.identifier.emailXiao, J: jiaxiao@hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.emailLiong, EC: eclionga@hkucc.hku.hken_US
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4103/2225-4110.110411-
dc.identifier.hkuros214360en_US
dc.identifier.volume3en_US
dc.identifier.issue2-
dc.identifier.spage88en_US
dc.identifier.epage94en_US
dc.publisher.placeTaiwan-

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