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Article: Evolutionary genetics of human enterovirus 71: Origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene

TitleEvolutionary genetics of human enterovirus 71: Origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene
Authors
Issue Date2010
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2010, v. 84 n. 7, p. 3339-3350 How to Cite?
AbstractHuman enterovirus 71 (EV-71) is one of the major etiologic causes of hand, foot, and mouth disease (HFMD) among young children worldwide, with fatal instances of neurological complications becoming increasingly common. Global VP1 capsid sequences (n = 628) sampled over 4 decades were collected and subjected to comprehensive evolutionary analysis using a suite of phylogenetic and population genetic methods. We estimated that the common ancestor of human EV-71 likely emerged around 1941 (95% confidence interval [CI], 1929 to 1952), subsequently diverging into three genogroups: B, C, and the now extinct genogroup A. Genealogical analysis revealed that diverse lineages of genogroup B and C (subgenogroups B1 to B5 and C1 to C5) have each circulated cryptically in the human population for up to 5 years before causing large HFMD outbreaks, indicating the quiescent persistence of EV-71 in human populations. Estimated phylogenies showed a complex pattern of spatial structure within well-sampled subgenogroups, suggesting endemicity with occasional lineage migration among locations, such that past HFMD epidemics are unlikely to be linked to continuous transmission of a single strain of virus. In addition, rises in genetic diversity are correlated with the onset of epidemics, driven in part by the emergence of novel EV-71 subgenogroups. Using subgenogroup C1 as a model, we observe temporal strain replacement through time, and we investigate the evidence for positive selection at VP1 immunogenic sites. We discuss the consequences of the evolutionary dynamics of EV-71 for vaccine design and compare its phylodynamic behavior with that of influenza virus. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/182372
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTee, KKen_US
dc.contributor.authorLam, TTYen_US
dc.contributor.authorChan, YFen_US
dc.contributor.authorBible, JMen_US
dc.contributor.authorKamarulzaman, Aen_US
dc.contributor.authorTong, CYWen_US
dc.contributor.authorTakebe, Yen_US
dc.contributor.authorPybus, OGen_US
dc.date.accessioned2013-04-23T08:21:10Z-
dc.date.available2013-04-23T08:21:10Z-
dc.date.issued2010en_US
dc.identifier.citationJournal Of Virology, 2010, v. 84 n. 7, p. 3339-3350en_US
dc.identifier.issn0022-538Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/182372-
dc.description.abstractHuman enterovirus 71 (EV-71) is one of the major etiologic causes of hand, foot, and mouth disease (HFMD) among young children worldwide, with fatal instances of neurological complications becoming increasingly common. Global VP1 capsid sequences (n = 628) sampled over 4 decades were collected and subjected to comprehensive evolutionary analysis using a suite of phylogenetic and population genetic methods. We estimated that the common ancestor of human EV-71 likely emerged around 1941 (95% confidence interval [CI], 1929 to 1952), subsequently diverging into three genogroups: B, C, and the now extinct genogroup A. Genealogical analysis revealed that diverse lineages of genogroup B and C (subgenogroups B1 to B5 and C1 to C5) have each circulated cryptically in the human population for up to 5 years before causing large HFMD outbreaks, indicating the quiescent persistence of EV-71 in human populations. Estimated phylogenies showed a complex pattern of spatial structure within well-sampled subgenogroups, suggesting endemicity with occasional lineage migration among locations, such that past HFMD epidemics are unlikely to be linked to continuous transmission of a single strain of virus. In addition, rises in genetic diversity are correlated with the onset of epidemics, driven in part by the emergence of novel EV-71 subgenogroups. Using subgenogroup C1 as a model, we observe temporal strain replacement through time, and we investigate the evidence for positive selection at VP1 immunogenic sites. We discuss the consequences of the evolutionary dynamics of EV-71 for vaccine design and compare its phylodynamic behavior with that of influenza virus. Copyright © 2010, American Society for Microbiology. All Rights Reserved.en_US
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_US
dc.relation.ispartofJournal of Virologyen_US
dc.subject.meshCapsid Proteins - Geneticsen_US
dc.subject.meshEnterovirus A, Human - Classification - Geneticsen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshHumansen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshRecombination, Geneticen_US
dc.subject.meshSeasonsen_US
dc.subject.meshSelection, Geneticen_US
dc.titleEvolutionary genetics of human enterovirus 71: Origin, population dynamics, natural selection, and seasonal periodicity of the VP1 geneen_US
dc.typeArticleen_US
dc.identifier.emailLam, TTY: ttylam@hku.hken_US
dc.identifier.authorityLam, TTY=rp01733en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1128/JVI.01019-09en_US
dc.identifier.pmid20089660-
dc.identifier.scopuseid_2-s2.0-77949394259en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949394259&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume84en_US
dc.identifier.issue7en_US
dc.identifier.spage3339en_US
dc.identifier.epage3350en_US
dc.identifier.isiWOS:000275307400020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTee, KK=8301170700en_US
dc.identifier.scopusauthoridLam, TTY=36775821700en_US
dc.identifier.scopusauthoridChan, YF=8091117300en_US
dc.identifier.scopusauthoridBible, JM=6603012161en_US
dc.identifier.scopusauthoridKamarulzaman, A=6603019663en_US
dc.identifier.scopusauthoridTong, CYW=35294089600en_US
dc.identifier.scopusauthoridTakebe, Y=7006748793en_US
dc.identifier.scopusauthoridPybus, OG=6701390795en_US

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