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Article: Triple negative status is a poor prognostic indicator in Chinese women with breast cancer: A ten year review

TitleTriple negative status is a poor prognostic indicator in Chinese women with breast cancer: A ten year review
Authors
Issue Date2012
PublisherAsian Pacific Organization for Cancer Prevention. The Journal's web site is located at http://www.apocp.org
Citation
Asian Pacific Journal Of Cancer Prevention, 2012, v. 13 n. 5, p. 2109-2114 How to Cite?
AbstractBackground: Ethnic variation in tumor characteristics and clinical presentation of breast cancer is increasingly being emphasized. We studied the tumor characteristics and factors which may influence the presentation and prognosis of triple negative breast cancers (TNC) in a cohort of Chinese women. Methods: A prospective cohort of 1800 Chinese women with breast cancer was recruited in a tertiary referral unit in Hong Kong between 1995 and 2006 and was followed up with a median duration of 7.2 years. Of the total, 216 (12.0%) had TNC and 1584 (88.0%) had non-TNC. Their clinicopathological variables, epidemiological variables and clinical outcomes were evaluated. Results: Patients with TNC had similar age of presentation as those with non-TNC, while presenting at earlier stages (82.4% were stage 1-2, compared to 78.4% in non-TNC, p=0.035). They were likely to be associated with grade 3 cancer (Hazard Ratio(HR)=5.8, p<0.001). TNC showed higher chance of visceral relapse (HR=2.69, p<0.001), liver metastasis (HR=1.7, p=0.003) and brain metastasis (HR=1.8, p=0.003). Compared with non-TNC group, TNC had similar 10-year disease-free survival (82% vs 84%, p=0.148), overall survival (78% vs 79%, p=0.238) and breast cancer-specific mortality (18% vs 16%, p=0.095). However, TNC showed poorer 10-year stage 3 and 4 specific survival (stage 3: 53% vs. 67%, p=0.010; stage 4: 0% vs. 40%, p = 0.035). Conclusions: Chinese women with triple negative breast cancer do not have less aggressive biological behavior compared to the West and presentation at a later stage results in worse prognosis compared with those with non triple negative breast cancer.
Persistent Identifierhttp://hdl.handle.net/10722/182367
ISSN
2014 Impact Factor: 2.514
2015 SCImago Journal Rankings: 0.813
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, KKen_US
dc.contributor.authorChau, WWen_US
dc.contributor.authorWong, CHen_US
dc.contributor.authorWong, Ken_US
dc.contributor.authorFung, Nen_US
dc.contributor.authorLee, AJTen_US
dc.contributor.authorChoi, CLYen_US
dc.contributor.authorSuen, DTKen_US
dc.contributor.authorKwong, Aen_US
dc.date.accessioned2013-04-23T08:20:24Z-
dc.date.available2013-04-23T08:20:24Z-
dc.date.issued2012en_US
dc.identifier.citationAsian Pacific Journal Of Cancer Prevention, 2012, v. 13 n. 5, p. 2109-2114en_US
dc.identifier.issn1513-7368en_US
dc.identifier.urihttp://hdl.handle.net/10722/182367-
dc.description.abstractBackground: Ethnic variation in tumor characteristics and clinical presentation of breast cancer is increasingly being emphasized. We studied the tumor characteristics and factors which may influence the presentation and prognosis of triple negative breast cancers (TNC) in a cohort of Chinese women. Methods: A prospective cohort of 1800 Chinese women with breast cancer was recruited in a tertiary referral unit in Hong Kong between 1995 and 2006 and was followed up with a median duration of 7.2 years. Of the total, 216 (12.0%) had TNC and 1584 (88.0%) had non-TNC. Their clinicopathological variables, epidemiological variables and clinical outcomes were evaluated. Results: Patients with TNC had similar age of presentation as those with non-TNC, while presenting at earlier stages (82.4% were stage 1-2, compared to 78.4% in non-TNC, p=0.035). They were likely to be associated with grade 3 cancer (Hazard Ratio(HR)=5.8, p<0.001). TNC showed higher chance of visceral relapse (HR=2.69, p<0.001), liver metastasis (HR=1.7, p=0.003) and brain metastasis (HR=1.8, p=0.003). Compared with non-TNC group, TNC had similar 10-year disease-free survival (82% vs 84%, p=0.148), overall survival (78% vs 79%, p=0.238) and breast cancer-specific mortality (18% vs 16%, p=0.095). However, TNC showed poorer 10-year stage 3 and 4 specific survival (stage 3: 53% vs. 67%, p=0.010; stage 4: 0% vs. 40%, p = 0.035). Conclusions: Chinese women with triple negative breast cancer do not have less aggressive biological behavior compared to the West and presentation at a later stage results in worse prognosis compared with those with non triple negative breast cancer.en_US
dc.languageengen_US
dc.publisherAsian Pacific Organization for Cancer Prevention. The Journal's web site is located at http://www.apocp.orgen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBreast Neoplasms - Metabolism - Mortalityen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshReceptor, Erbb-2 - Metabolismen_US
dc.subject.meshReceptors, Estrogen - Metabolismen_US
dc.subject.meshReceptors, Progesterone - Metabolismen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTertiary Care Centersen_US
dc.titleTriple negative status is a poor prognostic indicator in Chinese women with breast cancer: A ten year reviewen_US
dc.typeArticleen_US
dc.identifier.emailKwong, A: avakwong@hkucc.hku.hken_US
dc.identifier.authorityKwong, A=rp01734en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.7314/APJCP.2012.13.5.2109en_US
dc.identifier.pmid22901178-
dc.identifier.scopuseid_2-s2.0-84872687525en_US
dc.identifier.hkuros217029-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84872687525&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue5en_US
dc.identifier.spage2109en_US
dc.identifier.epage2114en_US
dc.identifier.isiWOS:000309470100070-
dc.publisher.placeThailanden_US
dc.identifier.scopusauthoridMa, KK=55565756500en_US
dc.identifier.scopusauthoridChau, WW=54793992500en_US
dc.identifier.scopusauthoridWong, CH=55565330100en_US
dc.identifier.scopusauthoridWong, K=55565374900en_US
dc.identifier.scopusauthoridFung, N=55565621600en_US
dc.identifier.scopusauthoridLee, AJT=55565334000en_US
dc.identifier.scopusauthoridChoi, CLY=55565853200en_US
dc.identifier.scopusauthoridSuen, DTK=8876971300en_US
dc.identifier.scopusauthoridKwong, A=8913654300en_US

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