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Article: Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations

TitleBreast cancer risk factors differ between Asian and white women with BRCA1/2 mutations
Authors
KeywordsBrca1/2
Breast Cancer
Race/Ethnicity
Risk Factors
Snps
Issue Date2012
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1389-9600
Citation
Familial Cancer, 2012, v. 11 n. 3, p. 429-439 How to Cite?
AbstractThe prevalence and penetrance of BRCA1 and BRCA2 (BRCA1/2) mutations may differ between Asians and whites. We investigated BRCA1/2 mutations and cancer risk factors in a clinic-based sample. BRCA1/2 mutation carriers were enrolled from cancer genetics clinics in Hong Kong and California according to standardized entry criteria. We compared BRCA mutation position, cancer history, hormonal and reproductive exposures. We analyzed DNA samples for single-nucleotide polymorphisms reported to modify breast cancer risk. We performed logistic regression to identify independent predictors of breast cancer. Fifty Asian women and forty-nine white American women were enrolled. BRCA1 mutations were more common among whites (67 vs. 42 %, p = 0.02), and BRCA2 mutations among Asians (58 vs. 37 %, p = 0.04). More Asians had breast cancer (76 vs. 53 %, p = 0.03); more whites had relatives with breast cancer (86 vs. 50 %, p = 0.0003). More whites than Asians had breastfed (71 vs. 42 %, p = 0.005), had high BMI (median 24.3 vs. 21.2, p = 0.04), consumed alcohol (2 drinks/week vs. 0, p > 0.001), and had oophorectomy (61 vs. 34 %, p = 0.01). Asians had a higher frequency of risk-associated alleles in MAP3K1 (88 vs. 59 %, p = 0.005) and TOX3/TNRC9 (88 vs. 55 %, p = 0.0002). On logistic regression, MAP3K1 was associated with increased breast cancer risk for BRCA2, but not BRCA1 mutation carriers; breast density was associated with increased risk among Asians but not whites. We found significant differences in breast cancer risk factors between Asian and white BRCA1/2 mutation carriers. Further investigation of racial differences in BRCA1/2 mutation epidemiology could inform targeted cancer risk-reduction strategies. © Springer Science+Business Media B.V. 2012.
Persistent Identifierhttp://hdl.handle.net/10722/182365
ISSN
2015 Impact Factor: 2.09
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDe Bruin, MAen_US
dc.contributor.authorKwong, Aen_US
dc.contributor.authorGoldstein, BAen_US
dc.contributor.authorLipson, JAen_US
dc.contributor.authorIkeda, DMen_US
dc.contributor.authorMcpherson, Len_US
dc.contributor.authorSharma, Ben_US
dc.contributor.authorKardashian, Aen_US
dc.contributor.authorSchackmann, Een_US
dc.contributor.authorKingham, KEen_US
dc.contributor.authorMills, MAen_US
dc.contributor.authorWest, DWen_US
dc.contributor.authorFord, JMen_US
dc.contributor.authorKurian, AWen_US
dc.date.accessioned2013-04-23T08:20:22Z-
dc.date.available2013-04-23T08:20:22Z-
dc.date.issued2012en_US
dc.identifier.citationFamilial Cancer, 2012, v. 11 n. 3, p. 429-439en_US
dc.identifier.issn1389-9600en_US
dc.identifier.urihttp://hdl.handle.net/10722/182365-
dc.description.abstractThe prevalence and penetrance of BRCA1 and BRCA2 (BRCA1/2) mutations may differ between Asians and whites. We investigated BRCA1/2 mutations and cancer risk factors in a clinic-based sample. BRCA1/2 mutation carriers were enrolled from cancer genetics clinics in Hong Kong and California according to standardized entry criteria. We compared BRCA mutation position, cancer history, hormonal and reproductive exposures. We analyzed DNA samples for single-nucleotide polymorphisms reported to modify breast cancer risk. We performed logistic regression to identify independent predictors of breast cancer. Fifty Asian women and forty-nine white American women were enrolled. BRCA1 mutations were more common among whites (67 vs. 42 %, p = 0.02), and BRCA2 mutations among Asians (58 vs. 37 %, p = 0.04). More Asians had breast cancer (76 vs. 53 %, p = 0.03); more whites had relatives with breast cancer (86 vs. 50 %, p = 0.0003). More whites than Asians had breastfed (71 vs. 42 %, p = 0.005), had high BMI (median 24.3 vs. 21.2, p = 0.04), consumed alcohol (2 drinks/week vs. 0, p > 0.001), and had oophorectomy (61 vs. 34 %, p = 0.01). Asians had a higher frequency of risk-associated alleles in MAP3K1 (88 vs. 59 %, p = 0.005) and TOX3/TNRC9 (88 vs. 55 %, p = 0.0002). On logistic regression, MAP3K1 was associated with increased breast cancer risk for BRCA2, but not BRCA1 mutation carriers; breast density was associated with increased risk among Asians but not whites. We found significant differences in breast cancer risk factors between Asian and white BRCA1/2 mutation carriers. Further investigation of racial differences in BRCA1/2 mutation epidemiology could inform targeted cancer risk-reduction strategies. © Springer Science+Business Media B.V. 2012.en_US
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1389-9600en_US
dc.relation.ispartofFamilial Canceren_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectBrca1/2en_US
dc.subjectBreast Canceren_US
dc.subjectRace/Ethnicityen_US
dc.subjectRisk Factorsen_US
dc.subjectSnpsen_US
dc.titleBreast cancer risk factors differ between Asian and white women with BRCA1/2 mutationsen_US
dc.typeArticleen_US
dc.identifier.emailKwong, A: avakwong@hkucc.hku.hken_US
dc.identifier.authorityKwong, A=rp01734en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10689-012-9531-9en_US
dc.identifier.pmid22638769-
dc.identifier.scopuseid_2-s2.0-84870424733en_US
dc.identifier.hkuros212682-
dc.identifier.hkuros216912-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84870424733&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue3en_US
dc.identifier.spage429en_US
dc.identifier.epage439en_US
dc.identifier.isiWOS:000311025000016-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridDe Bruin, MA=55356260500en_US
dc.identifier.scopusauthoridKwong, A=8913654300en_US
dc.identifier.scopusauthoridGoldstein, BA=55503811400en_US
dc.identifier.scopusauthoridLipson, JA=7006318468en_US
dc.identifier.scopusauthoridIkeda, DM=55421397400en_US
dc.identifier.scopusauthoridMcPherson, L=7004681320en_US
dc.identifier.scopusauthoridSharma, B=55509102700en_US
dc.identifier.scopusauthoridKardashian, A=55248226400en_US
dc.identifier.scopusauthoridSchackmann, E=55272505300en_US
dc.identifier.scopusauthoridKingham, KE=6601960896en_US
dc.identifier.scopusauthoridMills, MA=7201488233en_US
dc.identifier.scopusauthoridWest, DW=7401998438en_US
dc.identifier.scopusauthoridFord, JM=7402915714en_US
dc.identifier.scopusauthoridKurian, AW=6701674280en_US

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