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Article: Magnetic resonance spectroscopy reveals N-acetylaspartate reduction in hippocampus and cingulate cortex after fear conditioning

TitleMagnetic resonance spectroscopy reveals N-acetylaspartate reduction in hippocampus and cingulate cortex after fear conditioning
Authors
KeywordsCingulate Cortex
Fear Conditioning
Hippocampus
Mouse Brain
N-Acetylaspartate
Proton Magnetic Resonance Spectroscopy
Issue Date2012
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresns
Citation
Psychiatry Research - Neuroimaging, 2012, v. 204 n. 2-3, p. 178-183 How to Cite?
AbstractThe fear conditioning in rodents provides a valuable translational tool to investigate the neural basis of learning and memory and potentially the neurobiology of post-traumatic stress disorder (PTSD). Neurobiological changes induced by fear conditioning have largely been examined ex vivo while progressive 'real-time' changes in vivo remain under-explored. Single voxel proton magnetic resonance spectroscopy (1H MRS) of the hippocampus, cingulate cortex and thalamus of adult male C57BL/6N mice (N=12) was performed at 1 day before, 1 day and 1 week after, fear conditioning training using a 7T scanner. N-acetylaspartate (NAA), a marker for neuronal integrity and viability, significantly decreased in the hippocampus at 1 day and 1 week post-conditioning. Significant NAA reduction was also observed in the cingulate cortex at 1 day post-conditioning. These findings of hippocampal NAA decrease indicate reduced neuronal dysfunction and/or neuronal integrity, contributing to the trauma-related PTSD-like symptoms. The neurochemical changes characterized by 1H MRS can shed light on the biochemical mechanisms of learning and memory. Moreover, such information can potentially facilitate prompt intervention for patients with psychiatric disorders. © 2012 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/182347
ISSN
2015 Impact Factor: 2.477
2015 SCImago Journal Rankings: 1.681
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, IYen_US
dc.contributor.authorDing, AYen_US
dc.contributor.authorLi, Qen_US
dc.contributor.authorMcAlonan, GMen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2013-04-23T08:19:31Z-
dc.date.available2013-04-23T08:19:31Z-
dc.date.issued2012en_US
dc.identifier.citationPsychiatry Research - Neuroimaging, 2012, v. 204 n. 2-3, p. 178-183en_US
dc.identifier.issn0925-4927en_US
dc.identifier.urihttp://hdl.handle.net/10722/182347-
dc.description.abstractThe fear conditioning in rodents provides a valuable translational tool to investigate the neural basis of learning and memory and potentially the neurobiology of post-traumatic stress disorder (PTSD). Neurobiological changes induced by fear conditioning have largely been examined ex vivo while progressive 'real-time' changes in vivo remain under-explored. Single voxel proton magnetic resonance spectroscopy (1H MRS) of the hippocampus, cingulate cortex and thalamus of adult male C57BL/6N mice (N=12) was performed at 1 day before, 1 day and 1 week after, fear conditioning training using a 7T scanner. N-acetylaspartate (NAA), a marker for neuronal integrity and viability, significantly decreased in the hippocampus at 1 day and 1 week post-conditioning. Significant NAA reduction was also observed in the cingulate cortex at 1 day post-conditioning. These findings of hippocampal NAA decrease indicate reduced neuronal dysfunction and/or neuronal integrity, contributing to the trauma-related PTSD-like symptoms. The neurochemical changes characterized by 1H MRS can shed light on the biochemical mechanisms of learning and memory. Moreover, such information can potentially facilitate prompt intervention for patients with psychiatric disorders. © 2012 Elsevier Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresnsen_US
dc.relation.ispartofPsychiatry Research - Neuroimagingen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Psychiatry Research - Neuroimaging. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychiatry Research - Neuroimaging, 2012, v. 204 n. 2-3, p. 178-183. DOI: 10.1016/j.pscychresns.2012.09.010-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCingulate Cortexen_US
dc.subjectFear Conditioningen_US
dc.subjectHippocampusen_US
dc.subjectMouse Brainen_US
dc.subjectN-Acetylaspartateen_US
dc.subjectProton Magnetic Resonance Spectroscopyen_US
dc.titleMagnetic resonance spectroscopy reveals N-acetylaspartate reduction in hippocampus and cingulate cortex after fear conditioningen_US
dc.typeArticleen_US
dc.identifier.emailZhou, IY: izhou@hku.hken_US
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityZhou, IY=rp01739en_US
dc.identifier.authorityMcAlonan, GM=rp00475en_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturepostprinten_US
dc.identifier.doi10.1016/j.pscychresns.2012.09.010en_US
dc.identifier.pmid23137804-
dc.identifier.scopuseid_2-s2.0-84872379365en_US
dc.identifier.hkuros217894-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84872379365&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume204en_US
dc.identifier.issue2-3en_US
dc.identifier.spage178en_US
dc.identifier.epage183en_US
dc.identifier.isiWOS:000314329200016-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridZhou, IY=35424838500en_US
dc.identifier.scopusauthoridDing, AY=55443036900en_US
dc.identifier.scopusauthoridLi, Q=36068669600en_US
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US

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