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Article: Association between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer

TitleAssociation between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer
Authors
Issue Date2012
PublisherAmerican Medical Association. The Journal's web site is located at http://jama.ama-assn.org/index.dtl
Citation
Jama - Journal Of The American Medical Association, 2012, v. 307 n. 4, p. 382-390 How to Cite?
AbstractContext: Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear. Objective: To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival patterns. Design, Setting, and Participants: A pooled analysis of 26 observational studies on the survival of women with ovarian cancer, which included data from 1213 EOC cases with pathogenic germline mutations in BRCA1 (n=909) or BRCA2 (n=304) and from 2666 noncarriers recruited and followed up at variable times between 1987 and 2010 (the median year of diagnosis was 1998). Main Outcome Measure: Five-year overall mortality. Results: The 5-year overall survival was 36% (95% CI, 34%-38%) for noncarriers, 44% (95% CI, 40%-48%) for BRCA1 carriers, and 52% (95% CI, 46%-58%) for BRCA2 carriers. After adjusting for study and year of diagnosis, BRCA1 and BRCA2 mutation carriers showed amore favorable survival than noncarriers (for BRCA1: hazard ratio [HR], 0.78; 95% CI, 0.68-0.89; P<.001; and for BRCA2: HR, 0.61; 95% CI, 0.50-0.76; P<.001). These survival differences remained after additional adjustment for stage, grade, histology, and age at diagnosis (for BRCA1: HR, 0.73; 95% CI, 0.64-0.84; P<.001; and for BRCA2: HR, 0.49; 95% CI, 0.39-0.61; P<.001). The BRCA1 HR estimate was significantly different from the HR estimated in the adjusted model (P for heterogeneity=.003). Conclusion: Among patients with invasive EOC, having a germline mutation in BRCA1 or BRCA2 was associated with improved 5-year overall survival. BRCA2 carriers had the best prognosis. ©2012 American Medical Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/182264
ISSN
2015 Impact Factor: 37.684
2015 SCImago Journal Rankings: 6.440
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBolton, KLen_HK
dc.contributor.authorChenevixTrench, Gen_HK
dc.contributor.authorGoh, Cen_HK
dc.contributor.authorSadetzki, Sen_HK
dc.contributor.authorRamus, SJen_HK
dc.contributor.authorKarlan, BYen_HK
dc.contributor.authorLambrechts, Den_HK
dc.contributor.authorDespierre, Een_HK
dc.contributor.authorBarrowdale, Den_HK
dc.contributor.authorMcGuffog, Len_HK
dc.contributor.authorHealey, Sen_HK
dc.contributor.authorEaston, DFen_HK
dc.contributor.authorSinilnikova, Oen_HK
dc.contributor.authorBenítez, Jen_HK
dc.contributor.authorGarcía, MJen_HK
dc.contributor.authorNeuhausen, Sen_HK
dc.contributor.authorGail, MHen_HK
dc.contributor.authorHartge, Pen_HK
dc.contributor.authorPeock, Sen_HK
dc.contributor.authorFrost, Den_HK
dc.contributor.authorEvans, DGen_HK
dc.contributor.authorEeles, Ren_HK
dc.contributor.authorGodwin, AKen_HK
dc.contributor.authorDaly, MBen_HK
dc.contributor.authorKwong, Aen_HK
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorLázaro, Cen_HK
dc.contributor.authorBlanco, Ien_HK
dc.contributor.authorMontagna, Men_HK
dc.contributor.authorD'Andrea, Een_HK
dc.contributor.authorNicoletto, MOen_HK
dc.contributor.authorJohnatty, SEen_HK
dc.contributor.authorKjær, SKen_HK
dc.contributor.authorJensen, Aen_HK
dc.contributor.authorHøgdall, Een_HK
dc.contributor.authorGoode, ELen_HK
dc.contributor.authorFridley, BLen_HK
dc.contributor.authorLoud, JTen_HK
dc.contributor.authorGreene, MHen_HK
dc.contributor.authorMai, PLen_HK
dc.contributor.authorChetrit, Aen_HK
dc.contributor.authorLubin, Fen_HK
dc.contributor.authorHirshYechezkel, Gen_HK
dc.contributor.authorGlendon, Gen_HK
dc.contributor.authorAndrulis, ILen_HK
dc.contributor.authorToland, AEen_HK
dc.contributor.authorSenter, Len_HK
dc.contributor.authorGore, MEen_HK
dc.contributor.authorGourley, Cen_HK
dc.contributor.authorMichie, COen_HK
dc.contributor.authorSong, Hen_HK
dc.contributor.authorTyrer, Jen_HK
dc.contributor.authorWhittemore, ASen_HK
dc.contributor.authorMcGuire, Ven_HK
dc.contributor.authorSieh, Wen_HK
dc.contributor.authorKristoffersson, Uen_HK
dc.contributor.authorOlsson, Hen_HK
dc.contributor.authorBorg, Åen_HK
dc.contributor.authorLevine, DAen_HK
dc.contributor.authorSteele, Len_HK
dc.contributor.authorBeattie, MSen_HK
dc.contributor.authorChan, Sen_HK
dc.contributor.authorNussbaum, RLen_HK
dc.contributor.authorMoysich, KBen_HK
dc.contributor.authorGross, Jen_HK
dc.contributor.authorCass, Ien_HK
dc.contributor.authorWalsh, Cen_HK
dc.contributor.authorLi, AJen_HK
dc.contributor.authorLeuchter, Ren_HK
dc.contributor.authorGordon, Oen_HK
dc.contributor.authorGarciaClosas, Men_HK
dc.contributor.authorGayther, SAen_HK
dc.contributor.authorChanock, SJen_HK
dc.contributor.authorAntoniou, ACen_HK
dc.contributor.authorPharoah, PDPen_HK
dc.date.accessioned2013-04-19T07:19:14Z-
dc.date.available2013-04-19T07:19:14Z-
dc.date.issued2012en_HK
dc.identifier.citationJama - Journal Of The American Medical Association, 2012, v. 307 n. 4, p. 382-390en_HK
dc.identifier.issn0098-7484en_HK
dc.identifier.urihttp://hdl.handle.net/10722/182264-
dc.description.abstractContext: Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear. Objective: To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival patterns. Design, Setting, and Participants: A pooled analysis of 26 observational studies on the survival of women with ovarian cancer, which included data from 1213 EOC cases with pathogenic germline mutations in BRCA1 (n=909) or BRCA2 (n=304) and from 2666 noncarriers recruited and followed up at variable times between 1987 and 2010 (the median year of diagnosis was 1998). Main Outcome Measure: Five-year overall mortality. Results: The 5-year overall survival was 36% (95% CI, 34%-38%) for noncarriers, 44% (95% CI, 40%-48%) for BRCA1 carriers, and 52% (95% CI, 46%-58%) for BRCA2 carriers. After adjusting for study and year of diagnosis, BRCA1 and BRCA2 mutation carriers showed amore favorable survival than noncarriers (for BRCA1: hazard ratio [HR], 0.78; 95% CI, 0.68-0.89; P<.001; and for BRCA2: HR, 0.61; 95% CI, 0.50-0.76; P<.001). These survival differences remained after additional adjustment for stage, grade, histology, and age at diagnosis (for BRCA1: HR, 0.73; 95% CI, 0.64-0.84; P<.001; and for BRCA2: HR, 0.49; 95% CI, 0.39-0.61; P<.001). The BRCA1 HR estimate was significantly different from the HR estimated in the adjusted model (P for heterogeneity=.003). Conclusion: Among patients with invasive EOC, having a germline mutation in BRCA1 or BRCA2 was associated with improved 5-year overall survival. BRCA2 carriers had the best prognosis. ©2012 American Medical Association. All rights reserved.en_HK
dc.languageeng-
dc.publisherAmerican Medical Association. The Journal's web site is located at http://jama.ama-assn.org/index.dtlen_HK
dc.relation.ispartofJAMA - Journal of the American Medical Associationen_HK
dc.titleAssociation between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Canceren_HK
dc.typeArticleen_HK
dc.identifier.emailAndrulis, IL: avakwong@hkucc.hku.hken_HK
dc.identifier.authorityAndrulis, IL=rp01734en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1001/jama.2012.20en_HK
dc.identifier.pmid22274685-
dc.identifier.pmcidPMC3727895-
dc.identifier.scopuseid_2-s2.0-84856158117en_HK
dc.identifier.hkuros198686-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856158117&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume307en_HK
dc.identifier.issue4en_HK
dc.identifier.spage382en_HK
dc.identifier.epage390en_HK
dc.identifier.isiWOS:000299464000024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBolton, KL=24740981400en_HK
dc.identifier.scopusauthoridChenevixTrench, G=7005348926en_HK
dc.identifier.scopusauthoridGoh, C=53982811400en_HK
dc.identifier.scopusauthoridSadetzki, S=7003882851en_HK
dc.identifier.scopusauthoridRamus, SJ=7004611305en_HK
dc.identifier.scopusauthoridKarlan, BY=7006780020en_HK
dc.identifier.scopusauthoridLambrechts, D=6701310747en_HK
dc.identifier.scopusauthoridDespierre, E=12796979400en_HK
dc.identifier.scopusauthoridBarrowdale, D=36472978900en_HK
dc.identifier.scopusauthoridMcGuffog, L=6507594428en_HK
dc.identifier.scopusauthoridHealey, S=7004226174en_HK
dc.identifier.scopusauthoridEaston, DF=16471950000en_HK
dc.identifier.scopusauthoridSinilnikova, O=6603563456en_HK
dc.identifier.scopusauthoridBenítez, J=7203010415en_HK
dc.identifier.scopusauthoridGarcía, MJ=7404278368en_HK
dc.identifier.scopusauthoridNeuhausen, S=36982152900en_HK
dc.identifier.scopusauthoridGail, MH=7102980683en_HK
dc.identifier.scopusauthoridHartge, P=7005897469en_HK
dc.identifier.scopusauthoridPeock, S=7101627254en_HK
dc.identifier.scopusauthoridFrost, D=7102929844en_HK
dc.identifier.scopusauthoridEvans, DG=24740981400en_HK
dc.identifier.scopusauthoridEeles, R=7005348926en_HK
dc.identifier.scopusauthoridGodwin, AK=53982811400en_HK
dc.identifier.scopusauthoridDaly, MB=7003882851en_HK
dc.identifier.scopusauthoridKwong, A=7004611305en_HK
dc.identifier.scopusauthoridMa, ESK=7006780020en_HK
dc.identifier.scopusauthoridLázaro, C=6701310747en_HK
dc.identifier.scopusauthoridBlanco, I=12796979400en_HK
dc.identifier.scopusauthoridMontagna, M=36472978900en_HK
dc.identifier.scopusauthoridD'Andrea, E=6507594428en_HK
dc.identifier.scopusauthoridNicoletto, MO=7004226174en_HK
dc.identifier.scopusauthoridJohnatty, SE=16471950000en_HK
dc.identifier.scopusauthoridKjær, SK=6603563456en_HK
dc.identifier.scopusauthoridJensen, A=7203010415en_HK
dc.identifier.scopusauthoridHøgdall, E=7404278368en_HK
dc.identifier.scopusauthoridGoode, EL=36982152900en_HK
dc.identifier.scopusauthoridFridley, BL=7102980683en_HK
dc.identifier.scopusauthoridLoud, JT=7005897469en_HK
dc.identifier.scopusauthoridGreene, MH=12446461100en_HK
dc.identifier.scopusauthoridMai, PL=35487260700en_HK
dc.identifier.scopusauthoridChetrit, A=35232938700en_HK
dc.identifier.scopusauthoridLubin, F=7006235391en_HK
dc.identifier.scopusauthoridHirshYechezkel, G=7004511914en_HK
dc.identifier.scopusauthoridGlendon, G=35375546500en_HK
dc.identifier.scopusauthoridAndrulis, IL=8913654300en_HK
dc.identifier.scopusauthoridToland, AE=7202039934en_HK
dc.identifier.scopusauthoridSenter, L=7006545245en_HK
dc.identifier.scopusauthoridGore, ME=26645417200en_HK
dc.identifier.scopusauthoridGourley, C=7102565584en_HK
dc.identifier.scopusauthoridMichie, CO=7003747399en_HK
dc.identifier.scopusauthoridSong, H=6602556892en_HK
dc.identifier.scopusauthoridTyrer, J=23008666700en_HK
dc.identifier.scopusauthoridWhittemore, AS=7004418213en_HK
dc.identifier.scopusauthoridMcGuire, V=7403020798en_HK
dc.identifier.scopusauthoridSieh, W=7003756888en_HK
dc.identifier.scopusauthoridKristoffersson, U=7004452379en_HK
dc.identifier.scopusauthoridOlsson, H=54916131000en_HK
dc.identifier.scopusauthoridBorg, Å=6603316421en_HK
dc.identifier.scopusauthoridLevine, DA=7201704950en_HK
dc.identifier.scopusauthoridSteele, L=23990964500en_HK
dc.identifier.scopusauthoridBeattie, MS=7005313707en_HK
dc.identifier.scopusauthoridChan, S=7003888778en_HK
dc.identifier.scopusauthoridNussbaum, RL=6602417080en_HK
dc.identifier.scopusauthoridMoysich, KB=6603381937en_HK
dc.identifier.scopusauthoridGross, J=7005655442en_HK
dc.identifier.scopusauthoridCass, I=54918080800en_HK
dc.identifier.scopusauthoridWalsh, C=13404374600en_HK
dc.identifier.scopusauthoridLi, AJ=7201669340en_HK
dc.identifier.scopusauthoridLeuchter, R=23102803600en_HK
dc.identifier.scopusauthoridGordon, O=25723592500en_HK
dc.identifier.scopusauthoridGarciaClosas, M=8968104900en_HK
dc.identifier.scopusauthoridGayther, SA=15045992700en_HK
dc.identifier.scopusauthoridChanock, SJ=7102391407en_HK
dc.identifier.scopusauthoridAntoniou, AC=7003494931en_HK
dc.identifier.scopusauthoridPharoah, PDP=15837920500en_HK

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